STRINGSTRING
EGLN3 EGLN3 ARNT ARNT ARNT2 ARNT2 KRAS KRAS PIK3R2 PIK3R2 VEGFA VEGFA PIK3CA PIK3CA FH FH MET MET PIK3CB PIK3CB PIK3R1 PIK3R1 PAK2 PAK2 TGFB3 TGFB3 MAPK1 MAPK1 PAK4 PAK4 MAP2K1 MAP2K1 HGF HGF PAK1 PAK1 AKT3 AKT3 ETS1 ETS1 RAC1 RAC1 HRAS HRAS TGFB1 TGFB1 PAK6 PAK6 CUL2 CUL2 CDC42 CDC42 CRK CRK BRAF BRAF GRB2 GRB2 ELOB ELOB EGLN2 EGLN2 TGFA TGFA SOS2 SOS2 TFE3 TFE3 PTPN11 PTPN11 NRAS NRAS RAP1B RAP1B MAPK3 MAPK3 EPAS1 EPAS1 SLC2A1 SLC2A1 HIF1A HIF1A RBX1 RBX1 RAF1 RAF1 AKT2 AKT2 PIK3R3 PIK3R3 AKT1 AKT1 PRCC PRCC VHL VHL CREBBP CREBBP PDGFB PDGFB SOS1 SOS1 BAD BAD PIK3CD PIK3CD MAP2K2 MAP2K2 RAP1A RAP1A RAPGEF1 RAPGEF1 ARAF ARAF JUN JUN FLCN FLCN EP300 EP300 CDKN1A CDKN1A PAK3 PAK3 EGLN1 EGLN1 PAK5 PAK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGLN3Egl nine homolog 3. (239 aa)
ARNTUncharacterized protein. (786 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (711 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
VEGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (489 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FHFumarate hydratase, mitochondrial. (510 aa)
METUncharacterized protein. (1381 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PAK4Non-specific serine/threonine protein kinase. (597 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
PAK1Non-specific serine/threonine protein kinase. (575 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ETS1ETS proto-oncogene 1, transcription factor. (548 aa)
RAC1Uncharacterized protein. (212 aa)
HRASTransforming protein p21. (189 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
ELOBTranscription elongation factor B polypeptide 2 isoform a. (118 aa)
EGLN2Egl nine homolog 2. (405 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa)
SOS2Uncharacterized protein. (1332 aa)
TFE3Transcription factor E3. (575 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAP1BRas-related protein Rap-1b isoform 1. (184 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
EPAS1Endothelial PAS domain protein 1. (875 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (669 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (826 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
RAF1Uncharacterized protein. (668 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PIK3R3Uncharacterized protein. (507 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRCCUncharacterized protein. (511 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (213 aa)
CREBBPCREB-binding protein isoform a. (2442 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BADBcl2 antagonist of cell death. (167 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1297 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (680 aa)
EP300Histone acetyltransferase p300. (2414 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PAK3Uncharacterized protein. (580 aa)
EGLN1Uncharacterized protein. (426 aa)
PAK5Non-specific serine/threonine protein kinase. (748 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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