STRINGSTRING
AXIN1 AXIN1 KRAS KRAS PIK3R2 PIK3R2 GADD45B GADD45B PIK3CA PIK3CA ILK ILK PTEN PTEN TP53 TP53 PIK3CB PIK3CB EGF EGF PDPK1 PDPK1 PIK3R1 PIK3R1 CDH1 CDH1 MAPK1 MAPK1 MYC MYC MAP2K1 MAP2K1 CTNNA1 CTNNA1 CASP9 CASP9 ELK1 ELK1 AKT3 AKT3 TCF7L1 TCF7L1 HRAS HRAS MLH1 MLH1 TCF7L2 TCF7L2 FOXO3 FOXO3 POLK POLK CTNNA3 CTNNA3 CTNNA2 CTNNA2 GADD45A GADD45A LOC114672301 LOC114672301 BRAF BRAF GRB2 GRB2 GADD45G GADD45G EGFR EGFR SOS2 SOS2 NRAS NRAS MAPK3 MAPK3 APC2 APC2 RAF1 RAF1 AKT2 AKT2 PIK3R3 PIK3R3 GSK3B GSK3B AKT1 AKT1 CTNNB1 CTNNB1 ERBB2 ERBB2 LOC114675515 LOC114675515 SOS1 SOS1 BAK1 BAK1 BAD BAD PIK3CD PIK3CD MAP2K2 MAP2K2 APC APC ARAF ARAF AXIN2 AXIN2 CDKN1A CDKN1A CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AXIN1Axin 1. (867 aa)
KRASKRAS proto-oncogene, GTPase. (412 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ILKIntegrin-linked protein kinase. (452 aa)
PTENUncharacterized protein. (589 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CTNNA1Uncharacterized protein. (906 aa)
CASP9Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa)
ELK1ETS domain-containing protein Elk-1. (428 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
HRASTransforming protein p21. (189 aa)
MLH1MutL homolog 1. (756 aa)
TCF7L2Transcription factor 7 like 2. (632 aa)
FOXO3Forkhead box O3. (672 aa)
POLKDNA polymerase kappa. (868 aa)
CTNNA3Catenin alpha-3. (895 aa)
CTNNA2Catenin alpha 2. (953 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
LOC114672301ETS domain-containing protein. (488 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
SOS2Uncharacterized protein. (1332 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
APC2APC regulator of WNT signaling pathway 2. (2403 aa)
RAF1Uncharacterized protein. (668 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PIK3R3Uncharacterized protein. (507 aa)
GSK3BGlycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CTNNB1Catenin beta-1. (781 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
LOC114675515Uncharacterized protein. (152 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BAK1Uncharacterized protein. (261 aa)
BADBcl2 antagonist of cell death. (167 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
AXIN2Axin 2. (862 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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