STRINGSTRING
KRAS KRAS IGF1 IGF1 CAMK2B CAMK2B PIK3R2 PIK3R2 GADD45B GADD45B PDGFA PDGFA PIK3CA PIK3CA PLCG2 PLCG2 SHC1 SHC1 PTEN PTEN TP53 TP53 PIK3CB PIK3CB EGF EGF PIK3R1 PIK3R1 PDGFRB PDGFRB E2F2 E2F2 CAMK1D CAMK1D IGF1R IGF1R MAPK1 MAPK1 MDM2 MDM2 FIP1L1 FIP1L1 MAP2K1 MAP2K1 CALML5 CALML5 AKT3 AKT3 CAMK2G CAMK2G HRAS HRAS E2F1 E2F1 CDK4 CDK4 PRKCG PRKCG POLK POLK GADD45A GADD45A BRAF BRAF GRB2 GRB2 CALML6 CALML6 TGFA TGFA GADD45G GADD45G E2F3 E2F3 EGFR EGFR SOS2 SOS2 RB1 RB1 SHC3 SHC3 NRAS NRAS MAPK3 MAPK3 CALML3 CALML3 SHC4 SHC4 PLCG1 PLCG1 RAF1 RAF1 CAMK1G CAMK1G AKT2 AKT2 PIK3R3 PIK3R3 AKT1 AKT1 PRKCB PRKCB CAMK4 CAMK4 LOC114675515 LOC114675515 PDGFB PDGFB CAMK1 CAMK1 SOS1 SOS1 BAK1 BAK1 PIK3CD PIK3CD CAMK2A CAMK2A MAP2K2 MAP2K2 PRKCA PRKCA MTOR MTOR ARAF ARAF CALM2 CALM2 CALM3 CALM3 CDKN1A CDKN1A CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (412 aa)
IGF1Insulin like growth factor 1. (208 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (668 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SHC1SHC-transforming protein 1 isoform 3. (584 aa)
PTENUncharacterized protein. (589 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
E2F2E2F transcription factor 2. (437 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D isoform 2; Belongs to the protein kinase superfamily. (385 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
FIP1L1Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CALML5Calmodulin-like protein 5. (146 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (735 aa)
HRASTransforming protein p21. (189 aa)
E2F1E2F transcription factor 1. (437 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
POLKDNA polymerase kappa. (868 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CALML6Calmodulin like 6. (181 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
E2F3E2F transcription factor 3. (465 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
SOS2Uncharacterized protein. (1332 aa)
RB1Retinoblastoma-associated protein. (928 aa)
SHC3Uncharacterized protein. (596 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALML3Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa)
SHC4Src-like proteiny 2 domain-containing-transforming protein C4. (630 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RAF1Uncharacterized protein. (668 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PIK3R3Uncharacterized protein. (507 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (473 aa)
LOC114675515Uncharacterized protein. (152 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa)
CAMK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (494 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BAK1Uncharacterized protein. (261 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha. (622 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (204 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (194 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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