STRINGSTRING
ITGA3 ITGA3 CDKN2B CDKN2B LAMC3 LAMC3 ITGA6 ITGA6 PIK3R2 PIK3R2 GADD45B GADD45B RXRB RXRB PIK3CA PIK3CA BCL2L1 BCL2L1 LAMB1 LAMB1 COL4A6 COL4A6 COL4A1 COL4A1 ZBTB17 ZBTB17 PTEN PTEN TP53 TP53 PIK3CB PIK3CB LAMA1 LAMA1 TRAF2 TRAF2 PIK3R1 PIK3R1 E2F2 E2F2 ITGA2B ITGA2B FHIT FHIT COL4A4 COL4A4 MYC MYC LAMC1 LAMC1 PTGS2 PTGS2 TRAF4 TRAF4 ITGB1 ITGB1 CASP9 CASP9 TRAF6 TRAF6 ITGAV ITGAV AKT3 AKT3 CCNE1 CCNE1 LAMA2 LAMA2 COL4A2 COL4A2 APAF1 APAF1 E2F1 E2F1 CDK4 CDK4 IKBKB IKBKB POLK POLK NFKB1 NFKB1 TRAF5 TRAF5 GADD45A GADD45A IKBKG IKBKG LAMA3 LAMA3 CDK2 CDK2 CHUK CHUK GADD45G GADD45G E2F3 E2F3 RXRA RXRA RARB RARB RB1 RB1 PTK2 PTK2 LAMB2 LAMB2 ITGA2 ITGA2 LAMB4 LAMB4 NFKBIA NFKBIA RELA RELA COL4A5 COL4A5 TRAF1 TRAF1 AKT2 AKT2 SKP2 SKP2 PIK3R3 PIK3R3 AKT1 AKT1 XIAP XIAP BIRC7 BIRC7 LOC114675515 LOC114675515 LAMB3 LAMB3 FN1 FN1 CDKN1B CDKN1B TRAF3 TRAF3 BAK1 BAK1 PIK3CD PIK3CD RXRG RXRG BCL2 BCL2 CASP3 CASP3 BIRC3 BIRC3 CYCS CYCS COL4A3 COL4A3 BIRC2 BIRC2 CKS1B CKS1B CDKN1A CDKN1A LAMA4 LAMA4 CCND1 CCND1 LAMC2 LAMC2 NOS2 NOS2 CKS2 CKS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1064 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (158 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
ITGA6Integrin alpha-6 isoform a; Belongs to the integrin alpha chain family. (1091 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
RXRBRetinoid X receptor beta. (537 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BCL2L1Bcl-2-like protein 1 isoform 1. (233 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17 isoform 2. (800 aa)
PTENUncharacterized protein. (589 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
LAMA1Uncharacterized protein. (528 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (513 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
E2F2E2F transcription factor 2. (437 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1090 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
COL4A4Collagen type IV alpha 4 chain. (1692 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (471 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TRAF4TNF receptor-associated factor. (470 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CASP9Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (522 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
LAMA2Laminin subunit alpha 2. (3122 aa)
COL4A2Collagen type IV alpha 2 chain. (1739 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1206 aa)
E2F1E2F transcription factor 1. (437 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa)
POLKDNA polymerase kappa. (868 aa)
NFKB1Uncharacterized protein. (977 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa)
LAMA3Laminin subunit alpha 3. (3333 aa)
CDK2Diacylglycerol kinase. (1053 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
E2F3E2F transcription factor 3. (465 aa)
RXRARetinoid X receptor alpha. (620 aa)
RARBRetinoic acid receptor beta. (448 aa)
RB1Retinoblastoma-associated protein. (928 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
LAMB2Laminin subunit beta-2. (1798 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
LAMB4Laminin subunit beta 4. (1762 aa)
NFKBIANF-kappa-B inhibitor alpha. (317 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
TRAF1TNF receptor-associated factor. (416 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
SKP2S-phase kinase-associated protein 2 isoform 1. (424 aa)
PIK3R3Uncharacterized protein. (507 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
XIAPX-linked inhibitor of apoptosis. (535 aa)
BIRC7Baculoviral IAP repeat containing 7. (410 aa)
LOC114675515Uncharacterized protein. (152 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
FN1Fibronectin isoform 1 preproprotein. (2477 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
BAK1Uncharacterized protein. (261 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RXRGRetinoid X receptor gamma. (474 aa)
BCL2BCL2 apoptosis regulator. (241 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
COL4A3Collagen type IV alpha 3 chain. (1674 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
LAMA4Laminin subunit alpha 4. (1832 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
LAMC2Laminin subunit gamma 2. (1301 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1299 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.