STRINGSTRING
KRAS KRAS RASSF5 RASSF5 PIK3R2 PIK3R2 STAT5B STAT5B GADD45B GADD45B RXRB RXRB PIK3CA PIK3CA PLCG2 PLCG2 MET MET TP53 TP53 PIK3CB PIK3CB EGF EGF ALK ALK JAK3 JAK3 PDPK1 PDPK1 PIK3R1 PIK3R1 E2F2 E2F2 MAPK1 MAPK1 FHIT FHIT STK4 STK4 MAP2K1 MAP2K1 CASP9 CASP9 HGF HGF AKT3 AKT3 HRAS HRAS E2F1 E2F1 CDK4 CDK4 PRKCG PRKCG FOXO3 FOXO3 POLK POLK GADD45A GADD45A STAT3 STAT3 BRAF BRAF GRB2 GRB2 TGFA TGFA GADD45G GADD45G E2F3 E2F3 EGFR EGFR SOS2 SOS2 RXRA RXRA RARB RARB RB1 RB1 STAT5A STAT5A NRAS NRAS MAPK3 MAPK3 PLCG1 PLCG1 RAF1 RAF1 AKT2 AKT2 PIK3R3 PIK3R3 RASSF1 RASSF1 AKT1 AKT1 PRKCB PRKCB ERBB2 ERBB2 LOC114675515 LOC114675515 EML4 EML4 SOS1 SOS1 BAK1 BAK1 BAD BAD PIK3CD PIK3CD RXRG RXRG MAP2K2 MAP2K2 PRKCA PRKCA ARAF ARAF CDKN1A CDKN1A CCND1 CCND1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (412 aa)
RASSF5Ras association domain family member 5. (418 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
RXRBRetinoid X receptor beta. (537 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
METUncharacterized protein. (1381 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1213 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
JAK3Janus kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (602 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CASP9Caspase-9 isoform alpha preproprotein; Belongs to the peptidase C14A family. (416 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HRASTransforming protein p21. (189 aa)
E2F1E2F transcription factor 1. (437 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
FOXO3Forkhead box O3. (672 aa)
POLKDNA polymerase kappa. (868 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (165 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (166 aa)
GADD45GCytokine-responsive protein CR6. (159 aa)
E2F3E2F transcription factor 3. (465 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] (1210 aa)
SOS2Uncharacterized protein. (1332 aa)
RXRARetinoid X receptor alpha. (620 aa)
RARBRetinoic acid receptor beta. (448 aa)
RB1Retinoblastoma-associated protein. (928 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
RAF1Uncharacterized protein. (668 aa)
AKT2AKT serine/threonine kinase 2. (594 aa)
PIK3R3Uncharacterized protein. (507 aa)
RASSF1Ras association domain family member 1. (345 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ERBB2Receptor protein-tyrosine kinase. (1437 aa)
LOC114675515Uncharacterized protein. (152 aa)
EML4EMAP like 4. (1051 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1345 aa)
BAK1Uncharacterized protein. (261 aa)
BADBcl2 antagonist of cell death. (167 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RXRGRetinoid X receptor gamma. (474 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CCND1Uncharacterized protein; Belongs to the cyclin family. (303 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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