STRINGSTRING
IL23R IL23R IL12RB2 IL12RB2 TLR5 TLR5 IL5 IL5 IL13 IL13 IL4 IL4 STAT4 STAT4 IL17F IL17F GATA3 GATA3 IL17A IL17A IL21R IL21R FOXP3 FOXP3 IL18R1 IL18R1 TGFB3 TGFB3 IL12RB1 IL12RB1 RORC RORC TLR2 TLR2 IL2RG IL2RG IL22 IL22 MAMU-DPA MAMU-DPA IL2 IL2 IL12B IL12B IL12A IL12A IL10 IL10 TGFB1 TGFB1 MAMU-DMA MAMU-DMA NFKB1 NFKB1 IL18RAP IL18RAP IL23A IL23A TLR4 TLR4 SMAD3 SMAD3 STAT3 STAT3 SMAD2 SMAD2 RORA RORA NOD2 NOD2 IL6 IL6 HLA-DRA HLA-DRA RELA RELA TNF TNF STAT1 STAT1 STAT6 STAT6 TBX21 TBX21 IL21 IL21 IL1A IL1A IFNG IFNG IL4R IL4R LOC710149 LOC710149 IFNGR2 IFNGR2 IFNGR1 IFNGR1 LOC114669810 LOC114669810 JUN JUN MAMU-DOA MAMU-DOA HLA-DRB5 HLA-DRB5 ENSMMUP00000076578 ENSMMUP00000076578 MAF MAF IL18 IL18 IL1B IL1B NFATC1 NFATC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL23RInterleukin 23 receptor. (629 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (863 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (831 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (132 aa)
IL13Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. (146 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (153 aa)
STAT4Signal transducer and activator of transcription. (742 aa)
IL17FInterleukin-17F. (163 aa)
GATA3GATA binding protein 3. (444 aa)
IL17AInterleukin 17A. (155 aa)
IL21RInterleukin 21 receptor. (851 aa)
FOXP3Forkhead box P3. (539 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (789 aa)
RORCRAR related orphan receptor C. (518 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
IL2RGCytokine receptor common subunit gamma. (369 aa)
IL22Interleukin-22. (179 aa)
MAMU-DPAMHC class II antigen; Belongs to the MHC class II family. (260 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (379 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAMU-DMAIg-like domain-containing protein. (276 aa)
NFKB1Uncharacterized protein. (977 aa)
IL18RAPInterleukin 18 receptor accessory protein. (598 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
STAT3Signal transducer and activator of transcription. (871 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RORARAR related orphan receptor A. (555 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (266 aa)
HLA-DRAMamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (378 aa)
RELARELA proto-oncogene, NF-kB subunit. (544 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
STAT1Signal transducer and activator of transcription. (802 aa)
STAT6Signal transducer and activator of transcription. (902 aa)
TBX21T-box transcription factor 21. (539 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
IL4RInterleukin 4 receptor. (825 aa)
LOC710149Ig-like domain-containing protein. (228 aa)
IFNGR2Interferon gamma receptor 2. (336 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
LOC114669810Ig-like domain-containing protein; Belongs to the MHC class II family. (266 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (334 aa)
MAMU-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
HLA-DRB5Ig-like domain-containing protein. (287 aa)
ENSMMUP00000076578Ig-like domain-containing protein. (275 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (403 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
NFATC1Nuclear factor of activated T cells 1. (943 aa)
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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