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| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (185 aa) |
| | SDC2 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa) |
| | ASS1 | Argininosuccinate synthase. (412 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | SUMO3-2 | Ubiquitin-like domain-containing protein. (146 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (741 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | LOC700446 | Uncharacterized protein; Belongs to the GST superfamily. (245 aa) |
| | VEGFA | PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (489 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (249 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (1245 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | HMOX1 | Heme oxygenase 1. (288 aa) |
| | NCF1 | Neutrophil cytosolic factor 1. (390 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (822 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (433 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | ICAM1 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family. (543 aa) |
| | LOC705671 | Uncharacterized protein. (398 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3. (192 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | ITGA2B | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1090 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | CAV1 | Caveolin 1. (303 aa) |
| | MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 isoform A; Belongs to the protein kinase superfamily. (448 aa) |
| | GSTO1 | Glutathione S-transferase omega-1 isoform 1. (241 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa) |
| | MMP9 | Uncharacterized protein. (707 aa) |
| | THBD | Uncharacterized protein. (607 aa) |
| | CALML5 | Calmodulin-like protein 5. (146 aa) |
| | ACVR1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa) |
| | LOC706634 | Uncharacterized protein; Belongs to the GST superfamily. (244 aa) |
| | ACVR2B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | LOC702037 | Uncharacterized protein. (412 aa) |
| | ITGAV | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | SRC | Tyrosine-protein kinase. (644 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa) |
| | IL1R2 | Uncharacterized protein. (398 aa) |
| | RAC1 | Uncharacterized protein. (212 aa) |
| | VCAM1 | Vascular cell adhesion molecule 1. (739 aa) |
| | GSTT2B | Glutathione S-transferase theta-2; Belongs to the GST superfamily. (244 aa) |
| | HSP90B1 | Endoplasmin. (804 aa) |
| | TTC33 | Non-specific serine/threonine protein kinase. (581 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1. (756 aa) |
| | CDH5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (620 aa) |
| | SQSTM1 | Sequestosome 1. (440 aa) |
| | NFKB1 | Uncharacterized protein. (977 aa) |
| | MGST3 | Uncharacterized protein. (284 aa) |
| | CTSL | Cathepsin L; Belongs to the peptidase C1 family. (333 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (489 aa) |
| | GSTT1 | Uncharacterized protein. (281 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C isoform 1. (473 aa) |
| | NCF2 | Neutrophil cytosolic factor 2. (526 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | ACTG1 | Actin, cytoplasmic 2. (375 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | CALML6 | Calmodulin like 6. (181 aa) |
| | RHOA | Ras homolog family member A. (209 aa) |
| | SUMO1 | Small ubiquitin-related modifier. (101 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa) |
| | SELE | Selectin E. (610 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | MMP2 | 72 kDa type IV collagenase isoform a preproprotein. (660 aa) |
| | GSTA4 | Glutathione S-transferase alpha 4. (222 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1483 aa) |
| | CALML3 | Calmodulin-related protein NB-1; Belongs to the calmodulin family. (149 aa) |
| | MEF2A | Myocyte-specific enhancer factor 2A isoform 2. (503 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (544 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2. (192 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (963 aa) |
| | GSTP1 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (274 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (594 aa) |
| | MAP2K6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (335 aa) |
| | PLAT | Plasminogen activator; Belongs to the peptidase S1 family. (562 aa) |
| | PIK3R3 | Uncharacterized protein. (507 aa) |
| | MGST1 | Uncharacterized protein. (155 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PECAM1 | Platelet and endothelial cell adhesion molecule 1. (834 aa) |
| | EDN1 | Preproendothelin-1. (211 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (505 aa) |
| | TXN2 | Thioredoxin domain-containing protein. (169 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (561 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (271 aa) |
| | GSTA1 | Uncharacterized protein; Belongs to the GST superfamily. (247 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | GPC1 | Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (784 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (265 aa) |
| | KEAP1 | Kelch like ECH associated protein 1. (634 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | BCL2 | BCL2 apoptosis regulator. (241 aa) |
| | CAV2 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa) |
| | SDC4 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa) |
| | ACVR2A | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa) |
| | FOS | V-fos FBJ murine osteosarcoma viral oncogene-like protein. (380 aa) |
| | GSTO2 | Glutathione S-transferase O2; Belongs to the GST superfamily. (243 aa) |
| | MGST2 | Microsomal glutathione S-transferase 2 isoform 1. (147 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (334 aa) |
| | NPPC | C-type natriuretic peptide. (126 aa) |
| | SLC29A1 | HATPase_c domain-containing protein. (1077 aa) |
| | CALM2 | Uncharacterized protein; Belongs to the calmodulin family. (204 aa) |
| | LOC699679 | Uncharacterized protein; Belongs to the GST superfamily. (245 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (569 aa) |
| | CALM3 | Calmodulin 3; Belongs to the calmodulin family. (194 aa) |
| | BMP4 | Bone morphogenetic protein 4. (408 aa) |
| | NFE2L2 | Nuclear factor erythroid 2-related factor 2 isoform 1. (606 aa) |
| | DUSP1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | HSP90AA1 | HATPase_c domain-containing protein. (733 aa) |
| | NQO1 | NAD(P)H dehydrogenase [quinone] 1 isoform a. (274 aa) |
| | GSTM3 | Uncharacterized protein; Belongs to the GST superfamily. (434 aa) |
