23 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRIG1	Leucine rich repeats and immunoglobulin like domains 1. (1088 aa)
	LACRT	Lacritin. (137 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	ENSMNEP00000030245	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (152 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
	CD1C	CD1c molecule. (332 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (274 aa)
	ITGAX	Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1163 aa)
	DDC	Dopa decarboxylase. (480 aa)
	CD207	CD207 molecule. (328 aa)
	IL6	Interleukin 6. (214 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	KRT15	Keratin 15; Belongs to the intermediate filament family. (456 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (920 aa)
	KLF4	Kruppel like factor 4. (479 aa)
	COL1A2	Collagen type I alpha 2 chain. (1366 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	MMP1	Matrix metallopeptidase 1. (469 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	LCN1	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (176 aa)
	CIDEA	Cell death inducing DFFA like effector a. (196 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	CIDEA	ENSMNEP00000040295	ENSMNEP00000025680	Adiponectin, C1Q and collagen domain containing.	Cell death inducing DFFA like effector a.	0.436
ADIPOQ	FABP4	ENSMNEP00000040295	ENSMNEP00000016738	Adiponectin, C1Q and collagen domain containing.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.906
ADIPOQ	IL6	ENSMNEP00000040295	ENSMNEP00000000727	Adiponectin, C1Q and collagen domain containing.	Interleukin 6.	0.637
ADIPOQ	LEP	ENSMNEP00000040295	ENSMNEP00000022271	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.927
ADIPOQ	PPARG	ENSMNEP00000040295	ENSMNEP00000007307	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.737
ADIPOQ	TNF	ENSMNEP00000040295	ENSMNEP00000029202	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.556
ADIPOQ	UCP1	ENSMNEP00000040295	ENSMNEP00000021361	Adiponectin, C1Q and collagen domain containing.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.707
CD1C	CD207	ENSMNEP00000035270	ENSMNEP00000000324	CD1c molecule.	CD207 molecule.	0.533
CD1C	ITGAX	ENSMNEP00000035270	ENSMNEP00000043869	CD1c molecule.	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	0.474
CD207	CD1C	ENSMNEP00000000324	ENSMNEP00000035270	CD207 molecule.	CD1c molecule.	0.533
CD207	ITGAX	ENSMNEP00000000324	ENSMNEP00000043869	CD207 molecule.	Integrin subunit alpha X; Belongs to the integrin alpha chain family.	0.417
CIDEA	ADIPOQ	ENSMNEP00000025680	ENSMNEP00000040295	Cell death inducing DFFA like effector a.	Adiponectin, C1Q and collagen domain containing.	0.436
CIDEA	PPARG	ENSMNEP00000025680	ENSMNEP00000007307	Cell death inducing DFFA like effector a.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.420
CIDEA	UCP1	ENSMNEP00000025680	ENSMNEP00000021361	Cell death inducing DFFA like effector a.	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.834
FABP4	ADIPOQ	ENSMNEP00000016738	ENSMNEP00000040295	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Adiponectin, C1Q and collagen domain containing.	0.906
FABP4	PPARG	ENSMNEP00000016738	ENSMNEP00000007307	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.621
IL6	ADIPOQ	ENSMNEP00000000727	ENSMNEP00000040295	Interleukin 6.	Adiponectin, C1Q and collagen domain containing.	0.637
IL6	LEP	ENSMNEP00000000727	ENSMNEP00000022271	Interleukin 6.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.660
IL6	MMP1	ENSMNEP00000000727	ENSMNEP00000021815	Interleukin 6.	Matrix metallopeptidase 1.	0.407
IL6	PPARG	ENSMNEP00000000727	ENSMNEP00000007307	Interleukin 6.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.652