node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | CIDEA | ENSMNEP00000040295 | ENSMNEP00000025680 | Adiponectin, C1Q and collagen domain containing. | Cell death inducing DFFA like effector a. | 0.436 |
ADIPOQ | FABP4 | ENSMNEP00000040295 | ENSMNEP00000016738 | Adiponectin, C1Q and collagen domain containing. | Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.906 |
ADIPOQ | IL6 | ENSMNEP00000040295 | ENSMNEP00000000727 | Adiponectin, C1Q and collagen domain containing. | Interleukin 6. | 0.637 |
ADIPOQ | LEP | ENSMNEP00000040295 | ENSMNEP00000022271 | Adiponectin, C1Q and collagen domain containing. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.927 |
ADIPOQ | PPARG | ENSMNEP00000040295 | ENSMNEP00000007307 | Adiponectin, C1Q and collagen domain containing. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.737 |
ADIPOQ | TNF | ENSMNEP00000040295 | ENSMNEP00000029202 | Adiponectin, C1Q and collagen domain containing. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.556 |
ADIPOQ | UCP1 | ENSMNEP00000040295 | ENSMNEP00000021361 | Adiponectin, C1Q and collagen domain containing. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.707 |
CD1C | CD207 | ENSMNEP00000035270 | ENSMNEP00000000324 | CD1c molecule. | CD207 molecule. | 0.533 |
CD1C | ITGAX | ENSMNEP00000035270 | ENSMNEP00000043869 | CD1c molecule. | Integrin subunit alpha X; Belongs to the integrin alpha chain family. | 0.474 |
CD207 | CD1C | ENSMNEP00000000324 | ENSMNEP00000035270 | CD207 molecule. | CD1c molecule. | 0.533 |
CD207 | ITGAX | ENSMNEP00000000324 | ENSMNEP00000043869 | CD207 molecule. | Integrin subunit alpha X; Belongs to the integrin alpha chain family. | 0.417 |
CIDEA | ADIPOQ | ENSMNEP00000025680 | ENSMNEP00000040295 | Cell death inducing DFFA like effector a. | Adiponectin, C1Q and collagen domain containing. | 0.436 |
CIDEA | PPARG | ENSMNEP00000025680 | ENSMNEP00000007307 | Cell death inducing DFFA like effector a. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.420 |
CIDEA | UCP1 | ENSMNEP00000025680 | ENSMNEP00000021361 | Cell death inducing DFFA like effector a. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.834 |
FABP4 | ADIPOQ | ENSMNEP00000016738 | ENSMNEP00000040295 | Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Adiponectin, C1Q and collagen domain containing. | 0.906 |
FABP4 | PPARG | ENSMNEP00000016738 | ENSMNEP00000007307 | Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.621 |
IL6 | ADIPOQ | ENSMNEP00000000727 | ENSMNEP00000040295 | Interleukin 6. | Adiponectin, C1Q and collagen domain containing. | 0.637 |
IL6 | LEP | ENSMNEP00000000727 | ENSMNEP00000022271 | Interleukin 6. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.660 |
IL6 | MMP1 | ENSMNEP00000000727 | ENSMNEP00000021815 | Interleukin 6. | Matrix metallopeptidase 1. | 0.407 |
IL6 | PPARG | ENSMNEP00000000727 | ENSMNEP00000007307 | Interleukin 6. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.652 |