STRINGSTRING
CFTR CFTR ENSMNEP00000000555 ENSMNEP00000000555 ERAS ERAS THAP10 THAP10 BARX2 BARX2 LOC105464255 LOC105464255 ZNF580 ZNF580 TMEM158 TMEM158 ENSMNEP00000004019 ENSMNEP00000004019 EGFR EGFR LOC105492342 LOC105492342 PCSK5 PCSK5 ADAMTSL5 ADAMTSL5 R3HDM2 R3HDM2 WDR89 WDR89 C2CD6 C2CD6 SUV39H2 SUV39H2 TMPRSS2 TMPRSS2 SALL2 SALL2 ENSMNEP00000012269 ENSMNEP00000012269 ADGRL3 ADGRL3 TOP2A TOP2A PRKRIP1 PRKRIP1 UBE2Q1 UBE2Q1 ATP2C1 ATP2C1 HS3ST3A1 HS3ST3A1 SFTPC SFTPC PRIMA1 PRIMA1 CEP57 CEP57 ZDBF2 ZDBF2 STN1 STN1 EML4 EML4 HEMK1 HEMK1 PPM1N PPM1N FGFR1 FGFR1 ACTB ACTB ANXA5 ANXA5 ZNF850 ZNF850 BCL2 BCL2 CLVS1 CLVS1 PCSK9 PCSK9 AKT1 AKT1 PPFIBP2 PPFIBP2 ENSMNEP00000028540 ENSMNEP00000028540 ZNF865 ZNF865 ACE2 ACE2 MET MET CCDC122 CCDC122 AEN AEN JMJD8 JMJD8 GAPDH GAPDH CCK CCK MALT1 MALT1 TRIM55 TRIM55 ALK ALK ENSMNEP00000038177 ENSMNEP00000038177 SMCO2 SMCO2 CCDC83 CCDC83 KIAA1143 KIAA1143 KCNH7 KCNH7 DYNAP DYNAP GPRC5A GPRC5A PCSK7 PCSK7 ZNF808 ZNF808 ENSMNEP00000041867 ENSMNEP00000041867 PPP1R14D PPP1R14D MUC5B MUC5B TDRD9 TDRD9 TCF7L1 TCF7L1 KRAS KRAS
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)
ENSMNEP00000000555Mannosyltransferase. (593 aa)
ERASES cell expressed Ras. (233 aa)
THAP10THAP domain containing 10. (257 aa)
BARX2BARX homeobox 2. (279 aa)
LOC105464255Uncharacterized protein. (1197 aa)
ZNF580Zinc finger protein 580. (172 aa)
TMEM158Transmembrane protein 158 (gene/pseudogene). (298 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1887 aa)
ADAMTSL5ADAMTS like 5. (471 aa)
R3HDM2R3H domain containing 2. (1036 aa)
WDR89WD repeat domain 89. (387 aa)
C2CD6C2 calcium dependent domain containing 6. (1821 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
SALL2Spalt like transcription factor 2. (1045 aa)
ENSMNEP00000012269Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (408 aa)
ADGRL3Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family. (1580 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
PRKRIP1PRKR interacting protein 1. (181 aa)
UBE2Q1Ubiquitin conjugating enzyme E2 Q1. (488 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (983 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (405 aa)
SFTPCSurfactant protein C. (191 aa)
PRIMA1Proline rich membrane anchor 1. (153 aa)
CEP57Centrosomal protein 57. (504 aa)
ZDBF2Zinc finger DBF-type containing 2. (2357 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
EML4EMAP like 4. (991 aa)
HEMK1HemK methyltransferase family member 1. (338 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (425 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
ACTBActin beta. (379 aa)
ANXA5Annexin. (328 aa)
ZNF850Zinc finger protein 850. (1118 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CLVS1Clavesin 1. (354 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (811 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPFIBP2PPFIA binding protein 2. (926 aa)
ENSMNEP00000028540Uncharacterized protein. (139 aa)
ZNF865Zinc finger protein 865. (1046 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1403 aa)
CCDC122Coiled-coil domain containing 122. (273 aa)
AENApoptosis enhancing nuclease. (325 aa)
JMJD8Jumonji domain containing 8. (322 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
CCKCholecystokinin. (115 aa)
MALT1MALT1 paracaspase. (824 aa)
TRIM55Tripartite motif containing 55. (548 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
ENSMNEP00000038177Uncharacterized protein; Belongs to the actin family. (156 aa)
SMCO2Single-pass membrane protein with coiled-coil domains 2. (342 aa)
CCDC83Coiled-coil domain containing 83. (444 aa)
KIAA1143KIAA1143. (154 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1195 aa)
DYNAPDynactin associated protein. (210 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (355 aa)
PCSK7Proprotein convertase subtilisin/kexin type 7. (786 aa)
ZNF808Zinc finger protein 808. (923 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
PPP1R14DUncharacterized protein. (145 aa)
MUC5BMucin 5B, oligomeric mucus/gel-forming. (4260 aa)
TDRD9Tudor domain containing 9. (1382 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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