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| | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa) |
| | CD1D | CD1d molecule. (337 aa) |
| | FCAR | Fc fragment of IgA receptor. (287 aa) |
| | ENSMNEP00000045832 | Ig-like domain-containing protein. (319 aa) |
| | APP | Amyloid beta precursor protein. (770 aa) |
| | LOC105493689 | Uncharacterized protein; Belongs to the peptidase C14A family. (410 aa) |
| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1163 aa) |
| | SCART1 | Scavenger receptor family member expressed on T cells 1. (1006 aa) |
| | SPP1 | Secreted phosphoprotein 1. (314 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (458 aa) |
| | RUNX2 | RUNX family transcription factor 2. (542 aa) |
| | SOST | Sclerostin. (213 aa) |
| | TYROBP | TYRO protein tyrosine kinase binding protein. (144 aa) |
| | OSCAR | Osteoclast associated Ig-like receptor. (300 aa) |
| | DCSTAMP | Dendrocyte expressed seven transmembrane protein. (470 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | RBFOX3 | RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events. (400 aa) |
| | IL17A | Interleukin 17A. (155 aa) |
| | CD1C | CD1c molecule. (332 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1153 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (481 aa) |
| | MMP12 | Matrix metallopeptidase 12. (470 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (224 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) |
| | ARG1 | Arginase. (322 aa) |
| | CD68 | CD68 molecule. (354 aa) |
| | SOAT1 | O-acyltransferase. (556 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | C1QB | Complement C1q B chain. (253 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | CSF1 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (555 aa) |
| | JOSD2 | Josephin domain containing 2. (188 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | AIF1 | Allograft inflammatory factor 1. (147 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (230 aa) |
| | VMO1 | Vitelline membrane outer layer 1 homolog. (202 aa) |
| | CLEC4D | C-type lectin domain family 4 member D. (215 aa) |
| | FOXP3 | Forkhead box P3. (456 aa) |
| | CUNH15orf48 | Uncharacterized protein. (132 aa) |
| | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4. (1326 aa) |
| | ABCA7 | ATP binding cassette subfamily A member 7. (2128 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (331 aa) |
| | ABCA10 | ATP binding cassette subfamily A member 10. (1543 aa) |
| | CES1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa) |
| | CD1E | CD1e molecule. (387 aa) |
| | SELL | L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa) |
| | CTSK | Cathepsin K; Belongs to the peptidase C1 family. (348 aa) |
| | CCL22 | C-C motif chemokine ligand 22. (93 aa) |
| | EMILIN2 | Elastin microfibril interfacer 2. (1049 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | SLC66A1 | Solute carrier family 66 member 1. (305 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (317 aa) |
| | CD163 | CD163 molecule. (1155 aa) |
| | CX3CR1 | C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa) |
| | TMEM176B | Transmembrane protein 176B. (268 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1310 aa) |
| | CCR5 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (379 aa) |
| | SLAMF7 | SLAM family member 7. (335 aa) |
| | SIGLEC5 | Uncharacterized protein. (601 aa) |
| | MRC1 | Mannose receptor C-type 1. (1456 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (208 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (517 aa) |
| | M1AP | Meiosis 1 associated protein. (530 aa) |
| | CD8A | CD8a molecule. (253 aa) |
| | CCRL2 | C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (356 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa) |
| | CHIT1 | Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (466 aa) |
| | FUOM | Fucose mutarotase. (154 aa) |
| | AOC3 | Amine oxidase. (763 aa) |
| | IL13 | Interleukin 13. (146 aa) |
| | GPD1 | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa) |
| | ACP5 | Tartrate-resistant acid phosphatase type 5. (325 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (988 aa) |
| | BGLAP | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium (By similarity). (100 aa) |
| | CD1B | CD1b molecule. (333 aa) |
| | ENSMNEP00000002532 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (499 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (442 aa) |
| | ABCA9 | ATP binding cassette subfamily A member 9. (1624 aa) |
| | BDNF | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa) |
| | IL6 | Interleukin 6. (214 aa) |
| | ABCA6 | ATP binding cassette subfamily A member 6. (1618 aa) |
| | CD207 | CD207 molecule. (328 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
| | GPT | Glutamic--pyruvic transaminase. (496 aa) |
