5 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Interleukin 6. (214 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1B	IL6	ENSMNEP00000033521	ENSMNEP00000000727	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Interleukin 6.	0.932
IL1B	MMP3	ENSMNEP00000033521	ENSMNEP00000041138	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Matrix metallopeptidase 3.	0.567
IL1B	TNF	ENSMNEP00000033521	ENSMNEP00000029202	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.953
IL1B	TNFSF11	ENSMNEP00000033521	ENSMNEP00000015065	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	Tumor necrosis factor ligand superfamily member.	0.469
IL6	IL1B	ENSMNEP00000000727	ENSMNEP00000033521	Interleukin 6.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.932
IL6	MMP3	ENSMNEP00000000727	ENSMNEP00000041138	Interleukin 6.	Matrix metallopeptidase 3.	0.604
IL6	TNF	ENSMNEP00000000727	ENSMNEP00000029202	Interleukin 6.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.863
IL6	TNFSF11	ENSMNEP00000000727	ENSMNEP00000015065	Interleukin 6.	Tumor necrosis factor ligand superfamily member.	0.434
MMP3	IL1B	ENSMNEP00000041138	ENSMNEP00000033521	Matrix metallopeptidase 3.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.567
MMP3	IL6	ENSMNEP00000041138	ENSMNEP00000000727	Matrix metallopeptidase 3.	Interleukin 6.	0.604
MMP3	TNF	ENSMNEP00000041138	ENSMNEP00000029202	Matrix metallopeptidase 3.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.465
TNF	IL1B	ENSMNEP00000029202	ENSMNEP00000033521	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.953
TNF	IL6	ENSMNEP00000029202	ENSMNEP00000000727	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Interleukin 6.	0.863
TNF	MMP3	ENSMNEP00000029202	ENSMNEP00000041138	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Matrix metallopeptidase 3.	0.465
TNF	TNFSF11	ENSMNEP00000029202	ENSMNEP00000015065	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	Tumor necrosis factor ligand superfamily member.	0.584
TNFSF11	IL1B	ENSMNEP00000015065	ENSMNEP00000033521	Tumor necrosis factor ligand superfamily member.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.469
TNFSF11	IL6	ENSMNEP00000015065	ENSMNEP00000000727	Tumor necrosis factor ligand superfamily member.	Interleukin 6.	0.434
TNFSF11	TNF	ENSMNEP00000015065	ENSMNEP00000029202	Tumor necrosis factor ligand superfamily member.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.584