node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP1 | CASP12 | ENSMNEP00000001601 | ENSMNEP00000016869 | Caspase 1; Belongs to the peptidase C14A family. | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. | 0.845 |
CASP1 | IL1B | ENSMNEP00000001601 | ENSMNEP00000033521 | Caspase 1; Belongs to the peptidase C14A family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.976 |
CASP1 | IL6 | ENSMNEP00000001601 | ENSMNEP00000000727 | Caspase 1; Belongs to the peptidase C14A family. | Interleukin 6. | 0.512 |
CASP1 | TLR4 | ENSMNEP00000001601 | ENSMNEP00000035110 | Caspase 1; Belongs to the peptidase C14A family. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.514 |
CASP1 | TNF | ENSMNEP00000001601 | ENSMNEP00000029202 | Caspase 1; Belongs to the peptidase C14A family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.532 |
CASP12 | CASP1 | ENSMNEP00000016869 | ENSMNEP00000001601 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. | Caspase 1; Belongs to the peptidase C14A family. | 0.845 |
CASP12 | IL1B | ENSMNEP00000016869 | ENSMNEP00000033521 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.757 |
IL1B | CASP1 | ENSMNEP00000033521 | ENSMNEP00000001601 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Caspase 1; Belongs to the peptidase C14A family. | 0.976 |
IL1B | CASP12 | ENSMNEP00000033521 | ENSMNEP00000016869 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. | 0.757 |
IL1B | IL6 | ENSMNEP00000033521 | ENSMNEP00000000727 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Interleukin 6. | 0.932 |
IL1B | LOC105493689 | ENSMNEP00000033521 | ENSMNEP00000045751 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.973 |
IL1B | TLR4 | ENSMNEP00000033521 | ENSMNEP00000035110 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.778 |
IL1B | TNF | ENSMNEP00000033521 | ENSMNEP00000029202 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.953 |
IL6 | CASP1 | ENSMNEP00000000727 | ENSMNEP00000001601 | Interleukin 6. | Caspase 1; Belongs to the peptidase C14A family. | 0.512 |
IL6 | IL1B | ENSMNEP00000000727 | ENSMNEP00000033521 | Interleukin 6. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.932 |
IL6 | LOC105493689 | ENSMNEP00000000727 | ENSMNEP00000045751 | Interleukin 6. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.512 |
IL6 | TLR4 | ENSMNEP00000000727 | ENSMNEP00000035110 | Interleukin 6. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.832 |
IL6 | TNF | ENSMNEP00000000727 | ENSMNEP00000029202 | Interleukin 6. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.863 |
LOC105493689 | IL1B | ENSMNEP00000045751 | ENSMNEP00000033521 | Uncharacterized protein; Belongs to the peptidase C14A family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.973 |
LOC105493689 | IL6 | ENSMNEP00000045751 | ENSMNEP00000000727 | Uncharacterized protein; Belongs to the peptidase C14A family. | Interleukin 6. | 0.512 |