node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP5 | TNFSF11 | ENSMNEP00000003663 | ENSMNEP00000015065 | Tartrate-resistant acid phosphatase type 5. | Tumor necrosis factor ligand superfamily member. | 0.528 |
IL1B | IL6 | ENSMNEP00000033521 | ENSMNEP00000000727 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Interleukin 6. | 0.932 |
IL1B | NFKBIA | ENSMNEP00000033521 | ENSMNEP00000032512 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | NFKB inhibitor alpha. | 0.671 |
IL1B | PTGS2 | ENSMNEP00000033521 | ENSMNEP00000019419 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Prostaglandin-endoperoxide synthase 2. | 0.807 |
IL1B | TLR4 | ENSMNEP00000033521 | ENSMNEP00000035110 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.778 |
IL1B | TNF | ENSMNEP00000033521 | ENSMNEP00000029202 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.953 |
IL1B | TNFSF11 | ENSMNEP00000033521 | ENSMNEP00000015065 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Tumor necrosis factor ligand superfamily member. | 0.469 |
IL6 | IL1B | ENSMNEP00000000727 | ENSMNEP00000033521 | Interleukin 6. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.932 |
IL6 | NFKBIA | ENSMNEP00000000727 | ENSMNEP00000032512 | Interleukin 6. | NFKB inhibitor alpha. | 0.608 |
IL6 | PTGS2 | ENSMNEP00000000727 | ENSMNEP00000019419 | Interleukin 6. | Prostaglandin-endoperoxide synthase 2. | 0.706 |
IL6 | TLR4 | ENSMNEP00000000727 | ENSMNEP00000035110 | Interleukin 6. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.832 |
IL6 | TNF | ENSMNEP00000000727 | ENSMNEP00000029202 | Interleukin 6. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.863 |
IL6 | TNFSF11 | ENSMNEP00000000727 | ENSMNEP00000015065 | Interleukin 6. | Tumor necrosis factor ligand superfamily member. | 0.434 |
NFKBIA | IL1B | ENSMNEP00000032512 | ENSMNEP00000033521 | NFKB inhibitor alpha. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.671 |
NFKBIA | IL6 | ENSMNEP00000032512 | ENSMNEP00000000727 | NFKB inhibitor alpha. | Interleukin 6. | 0.608 |
NFKBIA | PTGS2 | ENSMNEP00000032512 | ENSMNEP00000019419 | NFKB inhibitor alpha. | Prostaglandin-endoperoxide synthase 2. | 0.482 |
NFKBIA | TLR4 | ENSMNEP00000032512 | ENSMNEP00000035110 | NFKB inhibitor alpha. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.578 |
NFKBIA | TNF | ENSMNEP00000032512 | ENSMNEP00000029202 | NFKB inhibitor alpha. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.664 |
PTGS2 | IL1B | ENSMNEP00000019419 | ENSMNEP00000033521 | Prostaglandin-endoperoxide synthase 2. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.807 |
PTGS2 | IL6 | ENSMNEP00000019419 | ENSMNEP00000000727 | Prostaglandin-endoperoxide synthase 2. | Interleukin 6. | 0.706 |