node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS5 | ENSMNEP00000020292 | ENSMNEP00000018874 | Aggrecan. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.754 |
ACAN | IL1B | ENSMNEP00000020292 | ENSMNEP00000033521 | Aggrecan. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.479 |
ACAN | MMP13 | ENSMNEP00000020292 | ENSMNEP00000028491 | Aggrecan. | Matrix metallopeptidase 13. | 0.600 |
ACAN | MMP3 | ENSMNEP00000020292 | ENSMNEP00000041138 | Aggrecan. | Matrix metallopeptidase 3. | 0.594 |
ADAMTS5 | ACAN | ENSMNEP00000018874 | ENSMNEP00000020292 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Aggrecan. | 0.754 |
ADAMTS5 | IL1B | ENSMNEP00000018874 | ENSMNEP00000033521 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.416 |
ADAMTS5 | MMP13 | ENSMNEP00000018874 | ENSMNEP00000028491 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Matrix metallopeptidase 13. | 0.575 |
ADAMTS5 | MMP3 | ENSMNEP00000018874 | ENSMNEP00000041138 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Matrix metallopeptidase 3. | 0.555 |
CRP | IL1B | ENSMNEP00000040200 | ENSMNEP00000033521 | Pentaxin. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.642 |
CRP | IL6 | ENSMNEP00000040200 | ENSMNEP00000000727 | Pentaxin. | Interleukin 6. | 0.751 |
IL1B | ACAN | ENSMNEP00000033521 | ENSMNEP00000020292 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Aggrecan. | 0.479 |
IL1B | ADAMTS5 | ENSMNEP00000033521 | ENSMNEP00000018874 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.416 |
IL1B | CRP | ENSMNEP00000033521 | ENSMNEP00000040200 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Pentaxin. | 0.642 |
IL1B | IL6 | ENSMNEP00000033521 | ENSMNEP00000000727 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Interleukin 6. | 0.932 |
IL1B | MMP13 | ENSMNEP00000033521 | ENSMNEP00000028491 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Matrix metallopeptidase 13. | 0.489 |
IL1B | MMP3 | ENSMNEP00000033521 | ENSMNEP00000041138 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Matrix metallopeptidase 3. | 0.567 |
IL6 | CRP | ENSMNEP00000000727 | ENSMNEP00000040200 | Interleukin 6. | Pentaxin. | 0.751 |
IL6 | IL1B | ENSMNEP00000000727 | ENSMNEP00000033521 | Interleukin 6. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.932 |
IL6 | MMP13 | ENSMNEP00000000727 | ENSMNEP00000028491 | Interleukin 6. | Matrix metallopeptidase 13. | 0.436 |
IL6 | MMP3 | ENSMNEP00000000727 | ENSMNEP00000041138 | Interleukin 6. | Matrix metallopeptidase 3. | 0.604 |