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| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | CANT1 | Calcium activated nucleotidase 1. (401 aa) |
| | PRTFDC1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (220 aa) |
| | ENSMNEP00000001503 | Uncharacterized protein. (73 aa) |
| | ENSMNEP00000001932 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (228 aa) |
| | ENSMNEP00000002012 | dUTPase domain-containing protein. (159 aa) |
| | ENSMNEP00000002186 | Uncharacterized protein. (402 aa) |
| | THTPA | Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (555 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (422 aa) |
| | AK5 | Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa) |
| | ENSMNEP00000005163 | dUTPase domain-containing protein. (66 aa) |
| | ADAL | Adenosine deaminase like. (355 aa) |
| | ENSMNEP00000005597 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (209 aa) |
| | DTYMK | Deoxythymidylate kinase. (212 aa) |
| | ENSMNEP00000006481 | NDK domain-containing protein; Belongs to the NDK family. (179 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (490 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (439 aa) |
| | GUK1 | Guanylate kinase 1. (272 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (517 aa) |
| | TPK1 | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa) |
| | ADSS1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (499 aa) |
| | ENSMNEP00000008691 | dUTPase domain-containing protein. (136 aa) |
| | UPRT | Uracil phosphoribosyltransferase homolog. (309 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (620 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | GMPS | Guanine monophosphate synthase. (661 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (534 aa) |
| | IMPDH | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (634 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (314 aa) |
| | NME4 | Nucleoside diphosphate kinase. (195 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (232 aa) |
| | NT5C1B | Uncharacterized protein. (610 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (371 aa) |
| | ADA | Adenosine deaminase. (449 aa) |
| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (178 aa) |
| | DCTD | dCMP deaminase. (189 aa) |
| | ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (471 aa) |
| | TK2 | Thymidine kinase 2. (281 aa) |
| | ENSMNEP00000020505 | PNP_UDP_1 domain-containing protein. (246 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (874 aa) |
| | AK7 | Adenylate kinase 7. (652 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (220 aa) |
| | AK4 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (161 aa) |
| | ENSMNEP00000024164 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (155 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (468 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | MANEAL | Mannosidase endo-alpha like. (457 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (497 aa) |
| | UCK1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa) |
| | NT5C2 | 5'-nucleotidase, cytosolic II. (572 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | TK1 | Thymidine kinase. (261 aa) |
| | ENSMNEP00000028510 | Uncharacterized protein; Belongs to the IMPDH/GMPR family. (458 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa) |
| | DGUOK | Deoxyguanosine kinase. (277 aa) |
| | TYMS | Thymidylate synthetase. (313 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (351 aa) |
| | ENSMNEP00000032397 | Uncharacterized protein. (298 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (363 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (427 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (747 aa) |
| | NME1-NME2 | Nucleoside diphosphate kinase. (292 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | AK9 | Adenylate kinase 9. (1914 aa) |
| | NT5DC4 | 5'-nucleotidase domain containing 4. (389 aa) |
| | DUT | dUTPase domain-containing protein. (252 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | NT5M | 5',3'-nucleotidase, mitochondrial. (228 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (201 aa) |
| | ADA2 | Adenosine deaminase 2. (501 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (784 aa) |
| | PAICS | AIRC domain-containing protein. (436 aa) |
| | ADK | Adenosine kinase. (362 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | TYMP | Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa) |
