STRINGSTRING
IMMP1L IMMP1L ENSMNEP00000000624 ENSMNEP00000000624 NPRL3 NPRL3 ENSMNEP00000000829 ENSMNEP00000000829 PRKAB2 PRKAB2 TSSK6 TSSK6 TPPP TPPP ATG2B ATG2B LAMTOR5 LAMTOR5 ZFP62 ZFP62 FLCN FLCN ENSMNEP00000003819 ENSMNEP00000003819 GABARAPL2 GABARAPL2 RRAGA RRAGA RPTOR RPTOR SQSTM1 SQSTM1 CTDSPL2 CTDSPL2 PRKAA2 PRKAA2 NRBF2 NRBF2 PDIK1L PDIK1L PRKN PRKN ENSMNEP00000006846 ENSMNEP00000006846 TTI1 TTI1 ANKIB1 ANKIB1 ATG7 ATG7 DEPTOR DEPTOR ATG13 ATG13 TP53INP1 TP53INP1 TRIB1 TRIB1 MTOR MTOR STK11 STK11 CASTOR1 CASTOR1 PRKAA1 PRKAA1 ATG16L1 ATG16L1 TELO2 TELO2 ATG9A ATG9A SESN3 SESN3 TBC1D7 TBC1D7 ENSMNEP00000012226 ENSMNEP00000012226 OPA1 OPA1 COX16 COX16 ENSMNEP00000013103 ENSMNEP00000013103 ULK2 ULK2 DMRTC2 DMRTC2 STRADB STRADB SH3GLB2 SH3GLB2 TECPR2 TECPR2 GSAP GSAP FKBP8 FKBP8 CAB39 CAB39 BECN1 BECN1 CAMKK2 CAMKK2 LOC105476784 LOC105476784 FOXO1 FOXO1 ATG14 ATG14 BRAT1 BRAT1 RB1CC1 RB1CC1 C12orf66 C12orf66 ENSMNEP00000015675 ENSMNEP00000015675 CRYBB3 CRYBB3 RRAGB RRAGB PGAM5 PGAM5 RHEBL1 RHEBL1 RPS6KB2 RPS6KB2 ENSMNEP00000016623 ENSMNEP00000016623 CFAP70 CFAP70 PRKAG1 PRKAG1 LRRC14 LRRC14 PINK1 PINK1 LAMTOR1 LAMTOR1 SESN1 SESN1 ATG5 ATG5 WDR24 WDR24 LAMTOR3 LAMTOR3 ATG12 ATG12 PLEKHM1 PLEKHM1 MAP1LC3A MAP1LC3A ENSMNEP00000019922 ENSMNEP00000019922 TRIB2 TRIB2 RRAGD RRAGD PRR5 PRR5 ENSMNEP00000020734 ENSMNEP00000020734 E4F1 E4F1 ULK1 ULK1 CYB561D2 CYB561D2 PRAF2 PRAF2 SIRT1 SIRT1 FRRS1 FRRS1 MAP1LC3B MAP1LC3B WIPI2 WIPI2 IRGM IRGM KPTN KPTN RICTOR RICTOR ENSMNEP00000023589 ENSMNEP00000023589 MAPKAP1 MAPKAP1 PIK3C3 PIK3C3 SGK2 SGK2 MIOS MIOS ATG16L2 ATG16L2 UVRAG UVRAG PRKAB1 PRKAB1 DMRTA2 DMRTA2 TRAK1 TRAK1 UBE2L3 UBE2L3 RRAGC RRAGC HMGCR HMGCR LAMTOR4 LAMTOR4 ATG9B ATG9B TSC1 TSC1 DNM1L DNM1L BRWD1 BRWD1 PRKAG3 PRKAG3 PIK3R4 PIK3R4 ATG4B ATG4B ATG101 ATG101 PRKAG2 PRKAG2 STK35 STK35 ATG4C ATG4C RHOT2 RHOT2 ENSMNEP00000030770 ENSMNEP00000030770 CA1 CA1 MFF MFF ULK3 ULK3 EEF2K EEF2K RUBCN RUBCN ITFG2 ITFG2 SH3GLB1 SH3GLB1 ATG4A ATG4A ATG2A ATG2A FOXO3 FOXO3 SESN2 SESN2 FNIP2 FNIP2 FUNDC1 FUNDC1 ENSMNEP00000034251 ENSMNEP00000034251 BMT2 BMT2 STRADA STRADA GABARAPL1 GABARAPL1 MFN1 MFN1 SLC38A9 SLC38A9 AMBRA1 AMBRA1 SZT2 SZT2 MLST8 MLST8 CRYGN CRYGN TTI2 TTI2 ENSMNEP00000037390 ENSMNEP00000037390 KIAA1671 KIAA1671 CAMKK1 CAMKK1 CASTOR2 CASTOR2 GMFB GMFB ATG10 ATG10 WIPI1 WIPI1 RHEB RHEB NPRL2 NPRL2 AKT3 AKT3 NBR1 NBR1 MUL1 MUL1 MYO19 MYO19 PRR5L PRR5L ATG3 ATG3 OMA1 OMA1 FOXO4 FOXO4 EPG5 EPG5 RHOT1 RHOT1 DCAF12 DCAF12 TSSK3 TSSK3 USP30 USP30 SETD7 SETD7 LOC105472095 LOC105472095 ATG4D ATG4D FNIP1 FNIP1 ENSMNEP00000043248 ENSMNEP00000043248 ENSMNEP00000043437 ENSMNEP00000043437 GABARAP GABARAP SGK3 SGK3 TSC2 TSC2 FOXO6 FOXO6 TP53INP2 TP53INP2 MFN2 MFN2 LAMTOR2 LAMTOR2 RPS6KB1 RPS6KB1 CAB39L CAB39L BCL2L13 BCL2L13 AKT1S1 AKT1S1 VMP1 VMP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IMMP1LMitochondrial inner membrane protease subunit. (166 aa)
ENSMNEP00000000624Uncharacterized protein. (57 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (505 aa)
ENSMNEP00000000829Uncharacterized protein. (278 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
TPPPTubulin polymerization promoting protein. (219 aa)
ATG2BAutophagy related 2B. (2078 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa)
ZFP62ZFP62 zinc finger protein. (904 aa)
FLCNFolliculin. (579 aa)
ENSMNEP00000003819Uncharacterized protein. (322 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
RRAGARas related GTP binding A. (313 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
SQSTM1Sequestosome 1. (440 aa)
CTDSPL2CTD small phosphatase like 2. (428 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NRBF2Nuclear receptor binding factor 2. (287 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (341 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ENSMNEP00000006846Miff domain-containing protein. (78 aa)
TTI1TELO2 interacting protein 1. (1089 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1089 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
DEPTORDEP domain containing MTOR interacting protein. (454 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
TELO2Telomere maintenance 2. (872 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (851 aa)
SESN3Sestrin 3. (492 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
ENSMNEP00000012226Uncharacterized protein. (104 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1015 aa)
COX16Cytochrome c oxidase assembly factor COX16. (106 aa)
ENSMNEP00000013103Uncharacterized protein. (90 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1035 aa)
DMRTC2DMRT like family C2. (418 aa)
STRADBSTE20 related adaptor beta. (418 aa)
SH3GLB2SH3 domain containing GRB2 like, endophilin B2. (404 aa)
TECPR2Tectonin beta-propeller repeat containing 2. (1288 aa)
GSAPGamma-secretase activating protein. (799 aa)
FKBP8Peptidylprolyl isomerase. (456 aa)
CAB39Calcium binding protein 39. (341 aa)
BECN1Beclin 1. (450 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (648 aa)
LOC105476784Uncharacterized protein. (147 aa)
FOXO1Forkhead box O1. (655 aa)
ATG14Autophagy related 14. (493 aa)
BRAT1BRCA1 associated ATM activator 1. (821 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
C12orf66Chromosome 12 open reading frame 66. (504 aa)
ENSMNEP00000015675Uncharacterized protein. (105 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
RRAGBRas related GTP binding B. (349 aa)
PGAM5Uncharacterized protein. (140 aa)
RHEBL1RHEB like 1. (183 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000016623Uncharacterized protein. (111 aa)
CFAP70Cilia and flagella associated protein 70. (1120 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
PINK1PTEN induced kinase 1. (581 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
SESN1Sestrin 1. (551 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
WDR24WD repeat domain 24. (902 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1055 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
ENSMNEP00000019922Uncharacterized protein. (144 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
RRAGDRas related GTP binding D. (400 aa)
PRR5Proline rich 5. (405 aa)
ENSMNEP00000020734Uncharacterized protein. (74 aa)
E4F1E4F transcription factor 1. (784 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
CYB561D2Cytochrome b561 family member D2. (222 aa)
PRAF2Uncharacterized protein. (361 aa)
SIRT1Sirtuin 1. (743 aa)
FRRS1Ferric chelate reductase 1. (623 aa)
MAP1LC3BUncharacterized protein. (125 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (451 aa)
IRGMImmunity related GTPase M. (170 aa)
KPTNKaptin, actin binding protein. (435 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
ENSMNEP00000023589DEP domain-containing protein. (1557 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
ATG16L2Autophagy related 16 like 2. (696 aa)
UVRAGUV radiation resistance associated. (699 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
DMRTA2DMRT like family A2. (540 aa)
TRAK1Trafficking kinesin protein 1. (953 aa)
UBE2L3Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
RRAGCRas related GTP binding C. (399 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
LAMTOR4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (112 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
TSC1TSC complex subunit 1. (1138 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (802 aa)
BRWD1Bromodomain and WD repeat domain containing 1. (2320 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (508 aa)
ATG101Autophagy related 101. (218 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (568 aa)
STK35Serine/threonine kinase 35. (533 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
RHOT2Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (618 aa)
ENSMNEP00000030770Uncharacterized protein. (103 aa)
CA1Carbonic anhydrase 1; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. (261 aa)
MFFMitochondrial fission factor. (341 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
EEF2KEukaryotic elongation factor 2 kinase. (713 aa)
RUBCNRubicon autophagy regulator. (1011 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
ATG2AAutophagy related 2A. (1968 aa)
FOXO3Forkhead box O3. (716 aa)
SESN2Sestrin 2. (480 aa)
FNIP2Folliculin interacting protein 2. (1153 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
ENSMNEP00000034251Protein kinase domain-containing protein. (397 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
STRADASTE20 related adaptor alpha. (431 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (688 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
SZT2SZT2 subunit of KICSTOR complex. (3432 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (182 aa)
TTI2TELO2 interacting protein 2. (508 aa)
ENSMNEP00000037390TPR_REGION domain-containing protein. (348 aa)
KIAA1671KIAA1671. (1803 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (520 aa)
CASTOR2Uncharacterized protein. (329 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (158 aa)
ATG10Autophagy related 10. (228 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (462 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NBR1NBR1 autophagy cargo receptor. (960 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
MYO19Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (962 aa)
PRR5LProline rich 5 like. (368 aa)
ATG3Autophagy-related protein 3. (314 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
FOXO4Forkhead box O4. (505 aa)
EPG5Ectopic P-granules autophagy protein 5 homolog. (2560 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (658 aa)
DCAF12DDB1 and CUL4 associated factor 12. (453 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
LOC105472095Coiled-coil_56 domain-containing protein. (106 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (447 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
ENSMNEP00000043248Uncharacterized protein. (82 aa)
ENSMNEP00000043437WD_REPEATS_REGION domain-containing protein. (500 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
TSC2TSC complex subunit 2. (1807 aa)
FOXO6Forkhead box O6. (627 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (135 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
BCL2L13BCL2 like 13. (509 aa)
AKT1S1AKT1 substrate 1. (276 aa)
VMP1Vacuole membrane protein 1. (406 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (24%) [HD]