STRINGSTRING
GREM2 GREM2 RNF111 RNF111 BMP7 BMP7 ACVR1C ACVR1C SMAD1 SMAD1 GDF5 GDF5 SKIL SKIL FST FST INHBB INHBB SMURF1 SMURF1 SMAD4 SMAD4 TGFBR1 TGFBR1 RGMB RGMB BMPR2 BMPR2 BMP5 BMP5 BMPR1A BMPR1A AMH AMH SMAD3 SMAD3 GDF11 GDF11 ACVR2B ACVR2B RGMA RGMA SMURF2 SMURF2 SMAD6 SMAD6 SMAD9 SMAD9 ENG ENG LTBP1 LTBP1 TGFBR3 TGFBR3 BMP6 BMP6 BAMBI BAMBI GDF6 GDF6 BMP4 BMP4 GDF7 GDF7 BMP2 BMP2 ACVR1 ACVR1 SMAD2 SMAD2 ZFYVE9 ZFYVE9 NOG NOG ACVRL1 ACVRL1 GDF2 GDF2 SMAD7 SMAD7 INHBE INHBE BMPR1B BMPR1B ZFYVE16 ZFYVE16 TGFBR2 TGFBR2 ACVR1B ACVR1B INHBA INHBA NEO1 NEO1 BMP10 BMP10 INHA INHA SMAD5 SMAD5 AMHR2 AMHR2 TGFB1 TGFB1 CHRD CHRD TGFB2 TGFB2 TGFB3 TGFB3 ACVR2A ACVR2A INHBC INHBC SKI SKI NBL1 NBL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GREM2Gremlin. (168 aa)
RNF111Ring finger protein 111. (1002 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GDF5Growth differentiation factor 5. (499 aa)
SKILSKI like proto-oncogene. (684 aa)
FSTFollistatin. (344 aa)
INHBBInhibin subunit beta B. (407 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (641 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (479 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AMHAnti-Mullerian hormone. (562 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GDF11Growth differentiation factor 11. (459 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
ENGEndoglin. (658 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1722 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
BMP6Bone morphogenetic protein 6. (513 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
GDF6Growth differentiation factor 6. (455 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF7Growth differentiation factor 7. (448 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
GDF2Growth differentiation factor 2. (429 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
INHBEInhibin subunit beta E. (351 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1540 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
INHBAInhibin subunit beta A. (426 aa)
NEO1Neogenin 1. (1498 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
INHAInhibin subunit alpha. (384 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (572 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (946 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
INHBCInhibin subunit beta C. (352 aa)
SKISKI proto-oncogene. (728 aa)
NBL1NBL1, DAN family BMP antagonist. (216 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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