STRINGSTRING
IL2 IL2 IL17B IL17B IL6 IL6 MIDN MIDN IFNA6 IFNA6 STAT1 STAT1 IL20RB IL20RB SOCS3 SOCS3 JAK1 JAK1 LOC105483006 LOC105483006 IL5 IL5 SIGIRR SIGIRR ENSMNEP00000002263 ENSMNEP00000002263 SOCS5 SOCS5 IL36B IL36B SOCS1 SOCS1 SOCS4 SOCS4 IL13 IL13 IL36G IL36G CRLF2 CRLF2 IL12RB1 IL12RB1 IL9 IL9 SOCS6 SOCS6 CISH CISH IL20 IL20 IL24 IL24 CSF3 CSF3 IL15RA IL15RA SOCS2 SOCS2 OSMR OSMR IL1R1 IL1R1 IL9R IL9R IL22 IL22 IL17RD IL17RD IL31 IL31 IL11 IL11 IL10RB IL10RB GAS2 GAS2 IL21 IL21 IL1RL2 IL1RL2 IL2RG IL2RG JAK2 JAK2 IRF9 IRF9 IL7R IL7R IFNL1 IFNL1 IL22RA2 IL22RA2 SOCS7 SOCS7 IL4R IL4R STAT5B STAT5B TSLP TSLP IL12RB2 IL12RB2 IRS2 IRS2 CRLF1 CRLF1 ENSMNEP00000018637 ENSMNEP00000018637 STAT3 STAT3 ENSMNEP00000019155 ENSMNEP00000019155 IL12B IL12B CSF3R CSF3R PTPN2 PTPN2 IL17D IL17D IL4 IL4 STAT4 STAT4 STAT2 STAT2 IFNLR1 IFNLR1 CLCF1 CLCF1 CTSS CTSS IFNGR2 IFNGR2 IL10RA IL10RA IL19 IL19 IL6ST IL6ST CSF2RB CSF2RB ENSMNEP00000023427 ENSMNEP00000023427 IL17C IL17C IL1R2 IL1R2 LIFR LIFR ENSMNEP00000024501 ENSMNEP00000024501 IL22RA1 IL22RA1 IL23A IL23A IL26 IL26 IL17RA IL17RA CTF1 CTF1 IL18BP IL18BP IL1RAP IL1RAP IL31RA IL31RA CSF2 CSF2 IL25 IL25 IL18RAP IL18RAP IL1F10 IL1F10 IL17RE IL17RE IFNB1 IFNB1 LOC105498418 LOC105498418 IL7 IL7 IFNE IFNE LIF LIF IL17F IL17F TYK2 TYK2 IL13RA1 IL13RA1 IL36RN IL36RN IL36A IL36A TP53BP2 TP53BP2 IL1B IL1B IL15 IL15 IL1A IL1A EPO EPO IL3RA IL3RA IL17RB IL17RB EPOR EPOR JAK3 JAK3 IL2RA IL2RA GALT GALT IL17A IL17A LOC105495378 LOC105495378 IL13RA2 IL13RA2 IL23R IL23R IL21R IL21R IFNAR2 IFNAR2 IL10 IL10 IFNA14 IFNA14 IL27 IL27 OSM OSM IL33 IL33 IL1RN IL1RN IL18R1 IL18R1 IL20RA IL20RA IFNGR1 IFNGR1 IL3 IL3 IL17RC IL17RC IL2RB IL2RB IL18 IL18 IL5RA IL5RA IL37 IL37 CSF2RA CSF2RA LOC105498430 LOC105498430 IL12A IL12A IL6R IL6R IL27RA IL27RA EBI3 EBI3 CNTFR CNTFR IFNG IFNG STAT6 STAT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
IL17BInterleukin 17B. (180 aa)
IL6Interleukin 6. (214 aa)
MIDNMidnolin. (482 aa)
IFNA6Interferon alpha 6. (190 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
JAK1Tyrosine-protein kinase. (1159 aa)
LOC105483006Uncharacterized protein. (197 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
SIGIRRSingle Ig and TIR domain containing. (499 aa)
ENSMNEP00000002263Uncharacterized protein. (329 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
IL36BInterleukin 36 beta. (164 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
IL13Interleukin 13. (146 aa)
IL36GInterleukin-1. (169 aa)
CRLF2Cytokine receptor like factor 2. (305 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (678 aa)
IL9Interleukin 9. (145 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
CISHCytokine inducible SH2 containing protein. (274 aa)
IL20Interleukin 20. (176 aa)
IL24Interleukin 24. (207 aa)
CSF3Colony stimulating factor 3. (207 aa)
IL15RAInterleukin 15 receptor subunit alpha. (301 aa)
SOCS2Suppressor of cytokine signaling 2. (210 aa)
OSMROncostatin M receptor. (977 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
IL9RInterleukin 9 receptor. (514 aa)
IL22Interleukin 22. (179 aa)
IL17RDInterleukin 17 receptor D. (739 aa)
IL31Interleukin 31. (163 aa)
IL11Interleukin 11. (199 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
GAS2Growth arrest specific 2. (314 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL1RL2Interleukin 1 receptor like 2. (562 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
IRF9Interferon regulatory factor 9. (392 aa)
IL7RInterleukin 7 receptor. (459 aa)
IFNL1Interferon lambda 1. (202 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (263 aa)
SOCS7Suppressor of cytokine signaling 7. (580 aa)
IL4RInterleukin 4 receptor. (825 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (842 aa)
IRS2Insulin receptor substrate 2. (1334 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
ENSMNEP00000018637Uncharacterized protein. (309 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
ENSMNEP00000019155Interfer-bind domain-containing protein. (338 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CSF3RColony stimulating factor 3 receptor. (836 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (385 aa)
IL17DInterleukin 17D. (202 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
IFNLR1Interferon lambda receptor 1. (525 aa)
CLCF1Cardiotrophin like cytokine factor 1. (230 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
IFNGR2Interferon gamma receptor 2. (312 aa)
IL10RAInterleukin 10 receptor subunit alpha. (580 aa)
IL19Interleukin 19. (214 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (918 aa)
ENSMNEP00000023427Uncharacterized protein. (198 aa)
IL17CInterleukin 17C. (197 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
ENSMNEP00000024501Uncharacterized protein. (456 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (574 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IL26Interleukin 26. (171 aa)
IL17RAInterleukin 17 receptor A. (865 aa)
CTF1Cardiotrophin 1. (201 aa)
IL18BPInterleukin 18 binding protein. (207 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
IL31RAInterleukin 31 receptor A. (763 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL25Interleukin 25. (160 aa)
IL18RAPInterleukin 18 receptor accessory protein. (598 aa)
IL1F10Interleukin-1. (152 aa)
IL17REInterleukin 17 receptor E. (696 aa)
IFNB1Interferon beta 1. (187 aa)
LOC105498418Uncharacterized protein. (190 aa)
IL7Interleukin 7. (184 aa)
IFNEInterferon epsilon. (194 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
IL17FInterleukin 17F. (163 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (425 aa)
IL36RNInterleukin-1. (155 aa)
IL36AInterleukin-1. (179 aa)
TP53BP2Tumor protein p53 binding protein 2. (1134 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (224 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IL3RAInterleukin 3 receptor subunit alpha. (346 aa)
IL17RBInterleukin 17 receptor B. (502 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (508 aa)
JAK3Tyrosine-protein kinase. (1088 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
GALTGalactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (783 aa)
IL17AInterleukin 17A. (155 aa)
LOC105495378Uncharacterized protein. (200 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (388 aa)
IL23RInterleukin 23 receptor. (576 aa)
IL21RInterleukin 21 receptor. (538 aa)
IFNAR2Uncharacterized protein. (516 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IFNA14Interferon alpha 14. (137 aa)
IL27Interleukin 27. (243 aa)
OSMOncostatin M. (252 aa)
IL33Interleukin 33. (270 aa)
IL1RNInterleukin-1. (179 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
IL20RAInterleukin 20 receptor subunit alpha. (552 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa)
IL17RCInterleukin 17 receptor C. (787 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
IL37Interleukin-1. (235 aa)
CSF2RAColony stimulating factor 2 receptor alpha subunit. (390 aa)
LOC105498430Uncharacterized protein. (189 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL6RInterleukin 6 receptor. (467 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
EBI3Epstein-Barr virus induced 3. (244 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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