(59 nodes) Clathrin coat, and Synaptic vesicle budding from presynaptic endocytic zone membrane network (Macaca nemestrina)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AP1M1	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
	NECAP1	NECAP endocytosis associated 1. (275 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (586 aa)
	REPS2	RALBP1 associated Eps domain containing 2. (652 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	AP3B2	AP-3 complex subunit beta. (1101 aa)
	ENSMNEP00000010927	B2-adapt-app_C domain-containing protein. (224 aa)
	DNAJC6	DnaJ heat shock protein family (Hsp40) member C6. (913 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (686 aa)
	EPN2	Epsin 2. (643 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1. (859 aa)
	NECAP2	NECAP endocytosis associated 2. (273 aa)
	REPS1	RALBP1 associated Eps domain containing 1. (796 aa)
	AP3D1	Adaptor related protein complex 3 subunit delta 1. (1325 aa)
	AAK1	AP2 associated kinase 1. (962 aa)
	AP1G2	AP-1 complex subunit gamma. (785 aa)
	AP1B1	AP complex subunit beta. (949 aa)
	EPS15	Epidermal growth factor receptor pathway substrate 15. (864 aa)
	EPN3	Epsin 3. (686 aa)
	GAK	Cyclin G associated kinase. (1311 aa)
	EPS15L1	Epidermal growth factor receptor pathway substrate 15 like 1. (926 aa)
	SNAP91	Synaptosome associated protein 91. (907 aa)
	FCHO1	FCH domain only 1. (872 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	AP4E1	AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa)
	AP1G1	AP-1 complex subunit gamma. (825 aa)
	ENSMNEP00000022897	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
	ARL5A	ADP ribosylation factor like GTPase 5A; Belongs to the small GTPase superfamily. Arf family. (179 aa)
	LOC105487574	Uncharacterized protein. (251 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	ENSMNEP00000026276	Rho-GAP domain-containing protein. (556 aa)
	AP3M1	AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
	ITSN2	Intersectin 2. (1697 aa)
	GAS7	Growth arrest specific 7. (476 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
	HTT	Huntingtin. (3123 aa)
	EPN1	Epsin 1. (662 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
	BMP2K	BMP2 inducible kinase. (1153 aa)
	LOC105472719	T-complex 10 like. (241 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	AP4S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (137 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (236 aa)
	AP3M2	AP-3 complex subunit mu-2. (418 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1639 aa)
	AP3S1	Adaptor related protein complex 3 subunit sigma 1. (193 aa)
	AP4B1	AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa)
	ARPIN	Clat_adaptor_s domain-containing protein. (394 aa)
	AP1M2	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (400 aa)
	HIP1	Huntingtin interacting protein 1. (968 aa)
	AP2B1	AP complex subunit beta. (959 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1068 aa)
	ENTHD1	ENTH domain containing 1. (608 aa)
	ITSN1	Intersectin 1. (1694 aa)
	AP4M1	AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (454 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (881 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	AP1B1	ENSMNEP00000016394	ENSMNEP00000017672	AP2 associated kinase 1.	AP complex subunit beta.	0.660
AAK1	AP1G1	ENSMNEP00000016394	ENSMNEP00000022565	AP2 associated kinase 1.	AP-1 complex subunit gamma.	0.403
AAK1	AP1G2	ENSMNEP00000016394	ENSMNEP00000017135	AP2 associated kinase 1.	AP-1 complex subunit gamma.	0.403
AAK1	AP2A1	ENSMNEP00000016394	ENSMNEP00000029500	AP2 associated kinase 1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.689
AAK1	AP2B1	ENSMNEP00000016394	ENSMNEP00000040184	AP2 associated kinase 1.	AP complex subunit beta.	0.695
AAK1	AP2M1	ENSMNEP00000016394	ENSMNEP00000028446	AP2 associated kinase 1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.881
AAK1	AP2S1	ENSMNEP00000016394	ENSMNEP00000025706	AP2 associated kinase 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.804
AAK1	AP4B1	ENSMNEP00000016394	ENSMNEP00000036838	AP2 associated kinase 1.	AP complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.562
AAK1	AP4E1	ENSMNEP00000016394	ENSMNEP00000021946	AP2 associated kinase 1.	AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.	0.403
AAK1	CLHC1	ENSMNEP00000016394	ENSMNEP00000006314	AP2 associated kinase 1.	Clathrin heavy chain linker domain-containing protein 1.	0.481
AAK1	CLTA	ENSMNEP00000016394	ENSMNEP00000035340	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.464
AAK1	CLTB	ENSMNEP00000016394	ENSMNEP00000033668	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.464
AAK1	CLTC	ENSMNEP00000016394	ENSMNEP00000005668	AP2 associated kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.510
AAK1	CLTCL1	ENSMNEP00000016394	ENSMNEP00000036393	AP2 associated kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.510
AAK1	DNAJC6	ENSMNEP00000016394	ENSMNEP00000011401	AP2 associated kinase 1.	DnaJ heat shock protein family (Hsp40) member C6.	0.805
AAK1	ENSMNEP00000010927	ENSMNEP00000016394	ENSMNEP00000010927	AP2 associated kinase 1.	B2-adapt-app_C domain-containing protein.	0.695
AAK1	ENSMNEP00000026276	ENSMNEP00000016394	ENSMNEP00000026276	AP2 associated kinase 1.	Rho-GAP domain-containing protein.	0.529
AAK1	EPS15	ENSMNEP00000016394	ENSMNEP00000017978	AP2 associated kinase 1.	Epidermal growth factor receptor pathway substrate 15.	0.851
AAK1	EPS15L1	ENSMNEP00000016394	ENSMNEP00000019380	AP2 associated kinase 1.	Epidermal growth factor receptor pathway substrate 15 like 1.	0.822
AAK1	FCHO1	ENSMNEP00000016394	ENSMNEP00000020572	AP2 associated kinase 1.	FCH domain only 1.	0.676