(14 nodes) Positive regulation of transcription of Notch receptor target, and Notch ligand, N-terminal domain network (Macaca nemestrina)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (969 aa)
	DLL3	Delta like canonical Notch ligand 3. (587 aa)
	NOTCH3	Notch receptor 3. (2275 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (517 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (500 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1134 aa)
	NOTCH4	Notch receptor 4. (2001 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (1152 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1238 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL3	ENSMNEP00000006458	ENSMNEP00000019844	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta like canonical Notch ligand 3.	0.923
DLL1	DLL4	ENSMNEP00000006458	ENSMNEP00000031676	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.897
DLL1	JAG1	ENSMNEP00000006458	ENSMNEP00000029427	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.543
DLL1	JAG2	ENSMNEP00000006458	ENSMNEP00000042804	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.411
DLL1	MAML1	ENSMNEP00000006458	ENSMNEP00000015492	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.632
DLL1	MAML2	ENSMNEP00000006458	ENSMNEP00000039362	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.632
DLL1	MAML3	ENSMNEP00000006458	ENSMNEP00000033904	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.631
DLL1	NOTCH1	ENSMNEP00000006458	ENSMNEP00000012653	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.986
DLL1	NOTCH2	ENSMNEP00000006458	ENSMNEP00000008317	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.971
DLL1	NOTCH3	ENSMNEP00000006458	ENSMNEP00000020785	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.964
DLL1	NOTCH4	ENSMNEP00000006458	ENSMNEP00000034378	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.997
DLL1	RBPJ	ENSMNEP00000006458	ENSMNEP00000028895	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.713
DLL1	RBPJL	ENSMNEP00000006458	ENSMNEP00000026935	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.448
DLL3	DLL1	ENSMNEP00000019844	ENSMNEP00000006458	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.923
DLL3	DLL4	ENSMNEP00000019844	ENSMNEP00000031676	Delta like canonical Notch ligand 3.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.890
DLL3	MAML1	ENSMNEP00000019844	ENSMNEP00000015492	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 1.	0.584
DLL3	MAML2	ENSMNEP00000019844	ENSMNEP00000039362	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 2.	0.584
DLL3	MAML3	ENSMNEP00000019844	ENSMNEP00000033904	Delta like canonical Notch ligand 3.	Mastermind like transcriptional coactivator 3.	0.584
DLL3	NOTCH1	ENSMNEP00000019844	ENSMNEP00000012653	Delta like canonical Notch ligand 3.	Notch receptor 1.	0.961
DLL3	NOTCH2	ENSMNEP00000019844	ENSMNEP00000008317	Delta like canonical Notch ligand 3.	Notch receptor 2.	0.961