(27 nodes) Lagging Strand Synthesis, and Epsilon DNA polymerase complex network (Macaca nemestrina)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	POLD4	Uncharacterized protein. (107 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (117 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	DNA2	DNA replication helicase/nuclease 2. (1061 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	LIG1	DNA ligase. (919 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	POLA1	DNA polymerase. (1478 aa)
	WDHD1	WD repeat and HMG-box DNA binding protein 1. (1127 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (374 aa)
	RFC1	Replication factor C subunit 1. (1148 aa)
	WRN	WRN RecQ like helicase. (1432 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (504 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RFC2	Replication factor C subunit 2. (340 aa)
	ENSMNEP00000023094	Uncharacterized protein. (159 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2263 aa)
	RAD17	RAD17 checkpoint clamp loader component. (681 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	POLD1	DNA polymerase. (1126 aa)
	ATAD5	ATPase family AAA domain containing 5. (1833 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	POLD3	Uncharacterized protein. (466 aa)
	ENSMNEP00000042122	Uncharacterized protein. (222 aa)
	ENSMNEP00000045253	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (234 aa)
	ENSMNEP00000045772	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	DNA2	ENSMNEP00000036019	ENSMNEP00000006852	ATPase family AAA domain containing 5.	DNA replication helicase/nuclease 2.	0.907
ATAD5	ENSMNEP00000023094	ENSMNEP00000036019	ENSMNEP00000023094	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.800
ATAD5	ENSMNEP00000042122	ENSMNEP00000036019	ENSMNEP00000042122	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.800
ATAD5	ENSMNEP00000045253	ENSMNEP00000036019	ENSMNEP00000045253	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.952
ATAD5	ENSMNEP00000045772	ENSMNEP00000036019	ENSMNEP00000045772	ATPase family AAA domain containing 5.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.867
ATAD5	FEN1	ENSMNEP00000036019	ENSMNEP00000003973	ATPase family AAA domain containing 5.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.944
ATAD5	LIG1	ENSMNEP00000036019	ENSMNEP00000013337	ATPase family AAA domain containing 5.	DNA ligase.	0.843
ATAD5	PCNA	ENSMNEP00000036019	ENSMNEP00000015788	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.952
ATAD5	POLA1	ENSMNEP00000036019	ENSMNEP00000016343	ATPase family AAA domain containing 5.	DNA polymerase.	0.866
ATAD5	POLD1	ENSMNEP00000036019	ENSMNEP00000031481	ATPase family AAA domain containing 5.	DNA polymerase.	0.793
ATAD5	POLD2	ENSMNEP00000036019	ENSMNEP00000017372	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.665
ATAD5	POLE	ENSMNEP00000036019	ENSMNEP00000023355	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.906
ATAD5	POLE2	ENSMNEP00000036019	ENSMNEP00000004984	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.843
ATAD5	POLE3	ENSMNEP00000036019	ENSMNEP00000041366	ATPase family AAA domain containing 5.	DNA polymerase epsilon 3, accessory subunit.	0.747
ATAD5	POLE4	ENSMNEP00000036019	ENSMNEP00000003144	ATPase family AAA domain containing 5.	DNA polymerase epsilon 4, accessory subunit.	0.705
ATAD5	PRIM1	ENSMNEP00000036019	ENSMNEP00000017101	ATPase family AAA domain containing 5.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.812
ATAD5	RAD17	ENSMNEP00000036019	ENSMNEP00000024510	ATPase family AAA domain containing 5.	RAD17 checkpoint clamp loader component.	0.941
ATAD5	RFC1	ENSMNEP00000036019	ENSMNEP00000017211	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.724
ATAD5	RFC2	ENSMNEP00000036019	ENSMNEP00000021943	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.975
ATAD5	RFC3	ENSMNEP00000036019	ENSMNEP00000017416	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.984