61 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	BBS4	Bardet-Biedl syndrome 4. (509 aa)
	LBX1	Ladybird homeobox 1. (281 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	CCDC103	Coiled-coil domain containing 103. (242 aa)
	AHI1	Abelson helper integration site 1. (1155 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	FOLR1	Folate receptor alpha. (257 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	ENSMNEP00000012395	GOLD domain-containing protein. (188 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	VANGL2	Vang-like protein. (521 aa)
	GATA4	GATA binding protein 4. (443 aa)
	FOXH1	Forkhead box H1. (366 aa)
	BBS7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	OVOL2	Ovo like zinc finger 2. (275 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	CCDC39	Coiled-coil domain containing 39. (942 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	CLUAP1	Clusterin associated protein 1. (433 aa)
	FOXN4	Forkhead box N4. (520 aa)
	STIL	STIL centriolar assembly protein. (1294 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	MESP1	Mesoderm posterior bHLH transcription factor 1. (272 aa)
	IFT52	Intraflagellar transport 52. (437 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (826 aa)
	C2CD3	C2 domain containing 3 centriole elongation regulator. (2325 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	TBX20	T-box transcription factor 20. (447 aa)
	NDRG4	NDRG family member 4. (391 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (637 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
	SRF	Serum response factor. (508 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (987 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	ZIC3	Zic family member 3. (466 aa)
	CCDC40	Coiled-coil domain containing 40. (1136 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	IFT172	Intraflagellar transport 172. (1744 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	ENSMNEP00000030156	BMERB domain-containing protein. (688 aa)
	TBX2	T-box transcription factor 2. (588 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (215 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (428 aa)
	SOX18	SRY-box transcription factor 18. (354 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
	SOX17	SRY-box transcription factor 17. (414 aa)
	NOTO	Notochord homeobox. (251 aa)
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1124 aa)
	ENG	Endoglin. (658 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (698 aa)
	MEF2C	Myocyte enhancer factor 2C. (486 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SETDB2	SET domain bifurcated histone lysine methyltransferase 2. (719 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHI1	ARL13B	ENSMNEP00000002246	ENSMNEP00000019597	Abelson helper integration site 1.	ADP ribosylation factor like GTPase 13B.	0.518
ARL13B	AHI1	ENSMNEP00000019597	ENSMNEP00000002246	ADP ribosylation factor like GTPase 13B.	Abelson helper integration site 1.	0.518
ARL13B	C2CD3	ENSMNEP00000019597	ENSMNEP00000040572	ADP ribosylation factor like GTPase 13B.	C2 domain containing 3 centriole elongation regulator.	0.485
ARL13B	IFT172	ENSMNEP00000019597	ENSMNEP00000030294	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 172.	0.408
ARL13B	IFT52	ENSMNEP00000019597	ENSMNEP00000041205	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.667
ARL13B	PKD2	ENSMNEP00000019597	ENSMNEP00000009632	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.515
ARL13B	SMO	ENSMNEP00000019597	ENSMNEP00000020637	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.483
BBS4	BBS7	ENSMNEP00000019000	ENSMNEP00000015478	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.994
BBS4	CLUAP1	ENSMNEP00000019000	ENSMNEP00000046008	Bardet-Biedl syndrome 4.	Clusterin associated protein 1.	0.558
BBS4	IFT172	ENSMNEP00000019000	ENSMNEP00000030294	Bardet-Biedl syndrome 4.	Intraflagellar transport 172.	0.565
BBS4	IFT52	ENSMNEP00000019000	ENSMNEP00000041205	Bardet-Biedl syndrome 4.	Intraflagellar transport 52.	0.665
BBS4	IFT57	ENSMNEP00000019000	ENSMNEP00000035093	Bardet-Biedl syndrome 4.	Intraflagellar transport 57.	0.696
BBS4	SMO	ENSMNEP00000019000	ENSMNEP00000020637	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.629
BBS7	BBS4	ENSMNEP00000015478	ENSMNEP00000019000	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Bardet-Biedl syndrome 4.	0.994
BBS7	CLUAP1	ENSMNEP00000015478	ENSMNEP00000046008	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Clusterin associated protein 1.	0.495
BBS7	IFT172	ENSMNEP00000015478	ENSMNEP00000030294	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Intraflagellar transport 172.	0.493
BBS7	IFT52	ENSMNEP00000015478	ENSMNEP00000041205	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Intraflagellar transport 52.	0.512
BBS7	IFT57	ENSMNEP00000015478	ENSMNEP00000035093	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Intraflagellar transport 57.	0.495
BBS7	PKD2	ENSMNEP00000015478	ENSMNEP00000009632	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Polycystin 2, transient receptor potential cation channel.	0.555
BBS7	SMO	ENSMNEP00000015478	ENSMNEP00000020637	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.656