27 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL1F10	Interleukin-1. (152 aa)
	EPHB6	EPH receptor B6. (1017 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (311 aa)
	RAB44	RAB44, member RAS oncogene family. (980 aa)
	CYSLTR1	Cysteinyl leukotriene receptor 1. (337 aa)
	IL36B	Interleukin 36 beta. (164 aa)
	IL36G	Interleukin-1. (169 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	NLRP6	NLR family pyrin domain containing 6. (1044 aa)
	NOTCH1	Notch receptor 1. (2556 aa)
	CD6	CD6 molecule. (699 aa)
	RASGRP1	RAS guanyl releasing protein 1. (832 aa)
	ENSMNEP00000019305	Uncharacterized protein. (638 aa)
	FCGR1A	Uncharacterized protein. (357 aa)
	IL31RA	Interleukin 31 receptor A. (763 aa)
	IL25	Interleukin 25. (160 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	CD68	CD68 molecule. (354 aa)
	LOC105498220	Uncharacterized protein. (342 aa)
	IL36RN	Interleukin-1. (155 aa)
	IL36A	Interleukin-1. (179 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	IL5RA	Interleukin 5 receptor subunit alpha. (420 aa)
	IL37	Interleukin-1. (235 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	GATA3	GATA binding protein 3. (444 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD68	FCGR1A	ENSMNEP00000031272	ENSMNEP00000019478	CD68 molecule.	Uncharacterized protein.	0.462
CD68	IL10	ENSMNEP00000031272	ENSMNEP00000036763	CD68 molecule.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.609
CD68	LOC105498220	ENSMNEP00000031272	ENSMNEP00000031919	CD68 molecule.	Uncharacterized protein.	0.675
CD68	TNF	ENSMNEP00000031272	ENSMNEP00000029202	CD68 molecule.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.635
FCGR1A	CD68	ENSMNEP00000019478	ENSMNEP00000031272	Uncharacterized protein.	CD68 molecule.	0.462
FCGR1A	LOC105498220	ENSMNEP00000019478	ENSMNEP00000031919	Uncharacterized protein.	Uncharacterized protein.	0.969
FCGR1A	TNF	ENSMNEP00000019478	ENSMNEP00000029202	Uncharacterized protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.411
GATA3	IL10	ENSMNEP00000043737	ENSMNEP00000036763	GATA binding protein 3.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.563
IL10	CD68	ENSMNEP00000036763	ENSMNEP00000031272	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	CD68 molecule.	0.609
IL10	GATA3	ENSMNEP00000036763	ENSMNEP00000043737	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	GATA binding protein 3.	0.563
IL10	IL5RA	ENSMNEP00000036763	ENSMNEP00000040799	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 5 receptor subunit alpha.	0.850
IL10	LOC105498220	ENSMNEP00000036763	ENSMNEP00000031919	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Uncharacterized protein.	0.660
IL10	TNF	ENSMNEP00000036763	ENSMNEP00000029202	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.868
IL1F10	IL36A	ENSMNEP00000028549	ENSMNEP00000032471	Interleukin-1.	Interleukin-1.	0.472
IL1F10	IL36B	ENSMNEP00000028549	ENSMNEP00000003446	Interleukin-1.	Interleukin 36 beta.	0.573
IL1F10	IL36G	ENSMNEP00000028549	ENSMNEP00000004810	Interleukin-1.	Interleukin-1.	0.457
IL1F10	IL36RN	ENSMNEP00000028549	ENSMNEP00000032380	Interleukin-1.	Interleukin-1.	0.457
IL1F10	TNF	ENSMNEP00000028549	ENSMNEP00000029202	Interleukin-1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.560
IL36A	IL1F10	ENSMNEP00000032471	ENSMNEP00000028549	Interleukin-1.	Interleukin-1.	0.472
IL36A	IL36B	ENSMNEP00000032471	ENSMNEP00000003446	Interleukin-1.	Interleukin 36 beta.	0.448