STRINGSTRING
APOA2 APOA2 IL2 IL2 AXL AXL KMT5C KMT5C LOC105467297 LOC105467297 FCRL3 FCRL3 IL6 IL6 TRIL TRIL TNFRSF14 TNFRSF14 CD81 CD81 HLA-G HLA-G ENSMNEP00000016907 ENSMNEP00000016907 ARID5A ARID5A PHB2 PHB2 B2M B2M IL5 IL5 CD40 CD40 ENSMNEP00000002536 ENSMNEP00000002536 SEMA7A SEMA7A PLCG2 PLCG2 ACP5 ACP5 PKN1 PKN1 TRAF2 TRAF2 IL13 IL13 WNT5A WNT5A FFAR2 FFAR2 ENSMNEP00000005266 ENSMNEP00000005266 FZD5 FZD5 LINGO3 LINGO3 HFE HFE PGC PGC ENSMNEP00000007269 ENSMNEP00000007269 UBE2J1 UBE2J1 CD55 CD55 CD36 CD36 APLF APLF LOC105474889 LOC105474889 ENSMNEP00000008836 ENSMNEP00000008836 KMT5B KMT5B DDX1 DDX1 KLK5 KLK5 IL1R1 IL1R1 RTN4 RTN4 PAXIP1 PAXIP1 PHB PHB GPRC5B GPRC5B ENSMNEP00000012002 ENSMNEP00000012002 PTPN22 PTPN22 NSD2 NSD2 PTPRC PTPRC ENSMNEP00000012842 ENSMNEP00000012842 CARD9 CARD9 ENSMNEP00000013138 ENSMNEP00000013138 IL21 IL21 CLNK CLNK STX4 STX4 TLR3 TLR3 ENSMNEP00000014571 ENSMNEP00000014571 RIF1 RIF1 DDX50 DDX50 CD86 CD86 IL4R IL4R NOD2 NOD2 DDX21 DDX21 ATG5 ATG5 IRAK3 IRAK3 CD226 CD226 ENSMNEP00000018092 ENSMNEP00000018092 KIT KIT ENSMNEP00000018745 ENSMNEP00000018745 KIR3DL3 KIR3DL3 SCIMP SCIMP INAVA INAVA CD28 CD28 ENSMNEP00000019591 ENSMNEP00000019591 MAD2L2 MAD2L2 IL4 IL4 LITAF LITAF BCL6 BCL6 SPON2 SPON2 XBP1 XBP1 DNAJB9 DNAJB9 ENSMNEP00000021271 ENSMNEP00000021271 SPINK5 SPINK5 SIRT1 SIRT1 CLCF1 CLCF1 ENSMNEP00000022134 ENSMNEP00000022134 PANX1 PANX1 ENSMNEP00000023924 ENSMNEP00000023924 TNFSF4 TNFSF4 SHLD2 SHLD2 TNFRSF1B TNFRSF1B FOXP3 FOXP3 BST2 BST2 SLAMF1 SLAMF1 MSH2 MSH2 CD74 CD74 ENSMNEP00000026182 ENSMNEP00000026182 TBX21 TBX21 NOD1 NOD1 EXOSC3 EXOSC3 TLR7 TLR7 BTK BTK SYK SYK IFNB1 IFNB1 PRKCZ PRKCZ TNF TNF TICAM1 TICAM1 EPX EPX KIR2DL4 KIR2DL4 IL17F IL17F NR4A3 NR4A3 TP53BP1 TP53BP1 HPX HPX NDFIP1 NDFIP1 CD40LG CD40LG TNFSF13 TNFSF13 ARG1 ARG1 MYD88 MYD88 ENSMNEP00000032223 ENSMNEP00000032223 DENND1B DENND1B MAP3K7 MAP3K7 CD96 CD96 TFRC TFRC C17orf99 C17orf99 HLA-F HLA-F SMAD7 SMAD7 DHX36 DHX36 IL1B IL1B SPHK2 SPHK2 CD37 CD37 THOC1 THOC1 MZB1 MZB1 RSAD2 RSAD2 NLRX1 NLRX1 JAK3 JAK3 PARP3 PARP3 TLR4 TLR4 MIF MIF ENSMNEP00000035659 ENSMNEP00000035659 MALT1 MALT1 IL17A IL17A ATAD5 ATAD5 BCL10 BCL10 IL13RA2 IL13RA2 SHLD1 SHLD1 ANGPT1 ANGPT1 PYCARD PYCARD IL10 IL10 CUEDC2 CUEDC2 ENSMNEP00000037129 ENSMNEP00000037129 EPHB2 EPHB2 DDX58 DDX58 ENSMNEP00000037716 ENSMNEP00000037716 IL33 IL33 RIPK2 RIPK2 TNFRSF4 TNFRSF4 HMCES HMCES TRAF6 TRAF6 IL18R1 IL18R1 CCR2 CCR2 TGFB1 TGFB1 IL18 IL18 CD160 CD160 TGFB2 TGFB2 TGFB3 TGFB3 RABGEF1 RABGEF1 CD244 CD244 SLC7A5 SLC7A5 NLRP3 NLRP3 MAPKAPK2 MAPKAPK2 ZPBP2 ZPBP2 ENSMNEP00000043350 ENSMNEP00000043350 TRPM4 TRPM4 GATA3 GATA3 ENSMNEP00000043817 ENSMNEP00000043817 SLC15A4 SLC15A4 IL27RA IL27RA CGAS CGAS SUPT6H SUPT6H LACC1 LACC1 STAT6 STAT6 MLH1 MLH1 ENSMNEP00000046151 ENSMNEP00000046151
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APOA2Apolipoprotein A2. (132 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
KMT5CLysine methyltransferase 5C. (461 aa)
LOC105467297Ig-like domain-containing protein; Belongs to the MHC class I family. (242 aa)
FCRL3Fc receptor like 3. (752 aa)
IL6Interleukin 6. (214 aa)
TRILTLR4 interactor with leucine rich repeats. (811 aa)
TNFRSF14TNF receptor superfamily member 14. (280 aa)
CD81Tetraspanin. (274 aa)
HLA-GIGc1 domain-containing protein; Belongs to the MHC class I family. (354 aa)
ENSMNEP00000016907Prohibitin. (173 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
PHB2Prohibitin. (299 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CD40CD40 molecule. (278 aa)
ENSMNEP00000002536Prohibitin. (151 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (697 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
PKN1Protein kinase N1. (949 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
IL13Interleukin 13. (146 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
ENSMNEP00000005266Prohibitin. (198 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (592 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
PGCProgastricsin; Belongs to the peptidase A1 family. (388 aa)
ENSMNEP00000007269VPS9 domain-containing protein. (363 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
CD55CD55 molecule (Cromer blood group). (551 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
APLFAprataxin and PNKP like factor. (512 aa)
LOC105474889AIG1-type G domain-containing protein. (307 aa)
ENSMNEP00000008836FAM35_C domain-containing protein. (216 aa)
KMT5BLysine methyltransferase 5B. (885 aa)
DDX1DEAD-box helicase 1. (740 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (291 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
RTN4Reticulon. (1118 aa)
PAXIP1PAX interacting protein 1. (1069 aa)
PHBProhibitin. (272 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
ENSMNEP00000012842Prohibitin. (239 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
ENSMNEP00000013138Ig-like domain-containing protein; Belongs to the MHC class I family. (352 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
CLNKCytokine dependent hematopoietic cell linker. (443 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
ENSMNEP00000014571Prohibitin. (318 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
DDX50Uncharacterized protein. (707 aa)
CD86CD86 molecule. (329 aa)
IL4RInterleukin 4 receptor. (825 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
DDX21DExD-box helicase 21. (783 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
CD226CD226 molecule. (316 aa)
ENSMNEP00000018092Prohibitin. (270 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
ENSMNEP00000018745Ig-like domain-containing protein; Belongs to the MHC class I family. (317 aa)
KIR3DL3Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (316 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (126 aa)
INAVAInnate immunity activator. (703 aa)
CD28CD28 molecule. (220 aa)
ENSMNEP00000019591Uncharacterized protein. (83 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
LITAFLipopolysaccharide induced TNF factor. (161 aa)
BCL6BCL6 transcription repressor. (708 aa)
SPON2Spondin 2. (331 aa)
XBP1BZIP domain-containing protein. (380 aa)
DNAJB9DnaJ heat shock protein family (Hsp40) member B9. (222 aa)
ENSMNEP00000021271Prohibitin. (286 aa)
SPINK5Serine peptidase inhibitor, Kazal type 5. (1087 aa)
SIRT1Sirtuin 1. (743 aa)
CLCF1Cardiotrophin like cytokine factor 1. (230 aa)
ENSMNEP00000022134Helicase C-terminal domain-containing protein. (315 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
ENSMNEP00000023924MHC_I-like_Ag-recog domain-containing protein. (162 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
SHLD2FAM35_C domain-containing protein. (801 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
FOXP3Forkhead box P3. (456 aa)
BST2Bone marrow stromal cell antigen 2. (182 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
CD74CD74 molecule. (294 aa)
ENSMNEP00000026182Prohibitin. (238 aa)
TBX21T-box transcription factor 21. (535 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
EXOSC3Exosome component 3. (275 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
BTKTyrosine-protein kinase. (659 aa)
SYKTyrosine-protein kinase. (629 aa)
IFNB1Interferon beta 1. (187 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
EPXEosinophil peroxidase. (715 aa)
KIR2DL4Uncharacterized protein. (416 aa)
IL17FInterleukin 17F. (163 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
TP53BP1Tumor protein p53 binding protein 1. (1926 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (250 aa)
ARG1Arginase. (322 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
ENSMNEP00000032223Prohibitin. (133 aa)
DENND1BDENN domain containing 1B. (790 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CD96CD96 molecule. (552 aa)
TFRCTransferrin receptor. (764 aa)
C17orf99Chromosome 17 open reading frame 99. (265 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (440 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
DHX36DEAH-box helicase 36. (1008 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
SPHK2Sphingosine kinase 2. (653 aa)
CD37Tetraspanin. (270 aa)
THOC1THO complex 1. (660 aa)
MZB1Marginal zone B and B1 cell specific protein. (188 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
NLRX1NLR family member X1. (972 aa)
JAK3Tyrosine-protein kinase. (1088 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
ENSMNEP00000035659Prohibitin. (112 aa)
MALT1MALT1 paracaspase. (824 aa)
IL17AInterleukin 17A. (155 aa)
ATAD5ATPase family AAA domain containing 5. (1833 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (388 aa)
SHLD1Shieldin complex subunit 1. (205 aa)
ANGPT1Angiopoietin 1. (498 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CUEDC2CUE domain containing 2. (292 aa)
ENSMNEP00000037129Ig-like domain-containing protein. (346 aa)
EPHB2EPH receptor B2. (1063 aa)
DDX58DExD/H-box helicase 58. (925 aa)
ENSMNEP00000037716Prohibitin. (236 aa)
IL33Interleukin 33. (270 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TNFRSF4TNF receptor superfamily member 4. (277 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CD160CD160 molecule. (181 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RABGEF1A20-type domain-containing protein. (469 aa)
CD244CD244 molecule. (367 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
ZPBP2Zona pellucida binding protein 2. (244 aa)
ENSMNEP00000043350Ig-like domain-containing protein. (233 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (992 aa)
GATA3GATA binding protein 3. (444 aa)
ENSMNEP00000043817Prohibitin. (263 aa)
SLC15A4Solute carrier family 15 member 4. (496 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
CGASCyclic GMP-AMP synthase. (522 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1713 aa)
LACC1Uncharacterized protein. (430 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
MLH1MutL homolog 1. (756 aa)
ENSMNEP00000046151Helicase C-terminal domain-containing protein. (633 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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