103 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD1C	CD1c molecule. (332 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
	HLA-F	Major histocompatibility complex, class I, F; Belongs to the MHC class I family. (440 aa)
	C17orf99	Chromosome 17 open reading frame 99. (265 aa)
	TFRC	Transferrin receptor. (764 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	DENND1B	DENN domain containing 1B. (790 aa)
	C3	Complement C3. (1642 aa)
	HPX	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
	NECTIN2	Nectin cell adhesion molecule 2. (513 aa)
	STAT5B	Signal transducer and activator of transcription. (783 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1044 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (644 aa)
	STX7	Syntaxin 7; Belongs to the syntaxin family. (261 aa)
	RIF1	Replication timing regulatory factor 1. (2466 aa)
	PVR	PVR cell adhesion molecule. (417 aa)
	CLNK	Cytokine dependent hematopoietic cell linker. (443 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1310 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	ENSMNEP00000012002	TNF receptor-associated factor. (457 aa)
	ENSMNEP00000011919	MHC_I-like_Ag-recog domain-containing protein. (259 aa)
	PAXIP1	PAX interacting protein 1. (1069 aa)
	IL1R1	Interleukin 1 receptor type 1. (569 aa)
	KMT5B	Lysine methyltransferase 5B. (885 aa)
	ENSMNEP00000008836	FAM35_C domain-containing protein. (216 aa)
	LOC105474889	AIG1-type G domain-containing protein. (307 aa)
	CD55	CD55 molecule (Cromer blood group). (551 aa)
	CRTAM	Cytotoxic and regulatory T cell molecule. (393 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (678 aa)
	LAG3	Lymphocyte activating 3. (525 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	CD1B	CD1b molecule. (333 aa)
	CD40	CD40 molecule. (278 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	ARID5A	AT-rich interaction domain 5A. (594 aa)
	CD81	Tetraspanin. (274 aa)
	KMT5C	Lysine methyltransferase 5C. (461 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	MLH1	MutL homolog 1. (756 aa)
	ENSMNEP00000045832	Ig-like domain-containing protein. (319 aa)
	CD1D	CD1d molecule. (337 aa)
	SHLD2	FAM35_C domain-containing protein. (801 aa)
	SH2D1A	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
	FOXP3	Forkhead box P3. (456 aa)
	IL23A	Interleukin 23 subunit alpha. (189 aa)
	MR1	Major histocompatibility complex, class I-related; Belongs to the MHC class I family. (385 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (356 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	EXOSC3	Exosome component 3. (275 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	FAM49B	Family with sequence similarity 49 member B. (365 aa)
	KLRK1	Killer cell lectin like receptor K1. (216 aa)
	LOC105477893	Uncharacterized protein. (1747 aa)
	SLC22A13	Solute carrier family 22 member 13. (551 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	SH2D1B	SH2 domain containing 1B. (132 aa)
	KIR2DL4	Uncharacterized protein. (416 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1926 aa)
	CD226	CD226 molecule. (316 aa)
	RASGRP1	RAS guanyl releasing protein 1. (832 aa)
	KIR3DL3	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (316 aa)
	ENSMNEP00000018934	MHC_I-like_Ag-recog domain-containing protein. (199 aa)
	FBXO38	F-box protein 38. (1188 aa)
	FCGR1A	Uncharacterized protein. (357 aa)
	CD28	CD28 molecule. (220 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (846 aa)
	CD1E	CD1e molecule. (387 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (211 aa)
	ENSMNEP00000019919	C-type lectin domain-containing protein. (191 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (230 aa)
	FCER2	Fc fragment of IgE receptor II. (321 aa)
	ENSMNEP00000023924	MHC_I-like_Ag-recog domain-containing protein. (162 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	KLRD1	Killer cell lectin like receptor D1. (179 aa)
	GATA3	GATA binding protein 3. (444 aa)
	NCR3	Natural cytotoxicity triggering receptor 3. (176 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	CADM1	Cell adhesion molecule 1. (473 aa)
	ENSMNEP00000040882	C-type lectin domain-containing protein. (239 aa)
	CD160	CD160 molecule. (181 aa)
	SLAMF6	SLAM family member 6. (331 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	IL18R1	Interleukin 18 receptor 1. (540 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	LAMP1	Lysosomal associated membrane protein 1. (416 aa)
	IL23R	Interleukin 23 receptor. (576 aa)
	SHLD1	Shieldin complex subunit 1. (205 aa)
	ATAD5	ATPase family AAA domain containing 5. (1833 aa)
	MALT1	MALT1 paracaspase. (824 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	B2M	ENSMNEP00000036019	ENSMNEP00000001702	ATPase family AAA domain containing 5.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.580
ATAD5	MAD2L2	ENSMNEP00000036019	ENSMNEP00000019779	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.630
ATAD5	MSH2	ENSMNEP00000036019	ENSMNEP00000026092	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.419
ATAD5	NSD2	ENSMNEP00000036019	ENSMNEP00000012515	ATPase family AAA domain containing 5.	Nuclear receptor binding SET domain protein 2.	0.599
B2M	ATAD5	ENSMNEP00000001702	ENSMNEP00000036019	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	ATPase family AAA domain containing 5.	0.580
B2M	CD1B	ENSMNEP00000001702	ENSMNEP00000002704	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1b molecule.	0.744
B2M	CD1C	ENSMNEP00000001702	ENSMNEP00000035270	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1c molecule.	0.744
B2M	CD1D	ENSMNEP00000001702	ENSMNEP00000046019	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1d molecule.	0.972
B2M	CD1E	ENSMNEP00000001702	ENSMNEP00000019670	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD1e molecule.	0.744
B2M	ENSMNEP00000023924	ENSMNEP00000001702	ENSMNEP00000023924	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MHC_I-like_Ag-recog domain-containing protein.	0.744
B2M	ENSMNEP00000045832	ENSMNEP00000001702	ENSMNEP00000045832	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.744
B2M	HLA-F	ENSMNEP00000001702	ENSMNEP00000032349	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I, F; Belongs to the MHC class I family.	0.983
B2M	KLRD1	ENSMNEP00000001702	ENSMNEP00000044149	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin like receptor D1.	0.700
B2M	MLH1	ENSMNEP00000001702	ENSMNEP00000045219	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	MutL homolog 1.	0.497
B2M	MR1	ENSMNEP00000001702	ENSMNEP00000025331	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Major histocompatibility complex, class I-related; Belongs to the MHC class I family.	0.693
B2M	MSH2	ENSMNEP00000001702	ENSMNEP00000026092	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.680
B2M	TFRC	ENSMNEP00000001702	ENSMNEP00000032313	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin receptor.	0.783
BTK	STAT6	ENSMNEP00000027450	ENSMNEP00000045215	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.428
BTK	TRAF2	ENSMNEP00000027450	ENSMNEP00000004472	Tyrosine-protein kinase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.922
BTK	VAV1	ENSMNEP00000027450	ENSMNEP00000019619	Tyrosine-protein kinase.	Vav guanine nucleotide exchange factor 1.	0.858