STRINGSTRING
CD74 CD74 TRIL TRIL TNFRSF14 TNFRSF14 CD81 CD81 ARID5A ARID5A B2M B2M SEMA7A SEMA7A PLCG2 PLCG2 ACP5 ACP5 TRAF2 TRAF2 WNT5A WNT5A FFAR2 FFAR2 FZD5 FZD5 LINGO3 LINGO3 HFE HFE ENSMNEP00000007269 ENSMNEP00000007269 UBE2J1 UBE2J1 CD55 CD55 CD36 CD36 LOC105474889 LOC105474889 DDX1 DDX1 AXL AXL IL1R1 IL1R1 RTN4 RTN4 GPRC5B GPRC5B ENSMNEP00000012002 ENSMNEP00000012002 CARD9 CARD9 CLNK CLNK TLR3 TLR3 DDX50 DDX50 NOD2 NOD2 DDX21 DDX21 ATG5 ATG5 IRAK3 IRAK3 CD226 CD226 KIT KIT KIR3DL3 KIR3DL3 SCIMP SCIMP INAVA INAVA ENSMNEP00000019591 ENSMNEP00000019591 LITAF LITAF BCL6 BCL6 SPON2 SPON2 SIRT1 SIRT1 ENSMNEP00000022134 ENSMNEP00000022134 PANX1 PANX1 ENSMNEP00000023924 ENSMNEP00000023924 TNFSF4 TNFSF4 TNFRSF1B TNFRSF1B FOXP3 FOXP3 BST2 BST2 SLAMF1 SLAMF1 TBX21 TBX21 NOD1 NOD1 TLR7 TLR7 BTK BTK APOA2 APOA2 SYK SYK IFNB1 IFNB1 PRKCZ PRKCZ TNF TNF TICAM1 TICAM1 EPX EPX KIR2DL4 KIR2DL4 NR4A3 NR4A3 ARG1 ARG1 MYD88 MYD88 DENND1B DENND1B MAP3K7 MAP3K7 CD96 CD96 HLA-F HLA-F SMAD7 SMAD7 DHX36 DHX36 IL1B IL1B SPHK2 SPHK2 RSAD2 RSAD2 NLRX1 NLRX1 JAK3 JAK3 TLR4 TLR4 MIF MIF MALT1 MALT1 BCL10 BCL10 ANGPT1 ANGPT1 PYCARD PYCARD IL10 IL10 CUEDC2 CUEDC2 DDX58 DDX58 RIPK2 RIPK2 TRAF6 TRAF6 IL18R1 IL18R1 CCR2 CCR2 TGFB1 TGFB1 IL18 IL18 CD160 CD160 TGFB2 TGFB2 TGFB3 TGFB3 RABGEF1 RABGEF1 SLC7A5 SLC7A5 NLRP3 NLRP3 MAPKAPK2 MAPKAPK2 TRPM4 TRPM4 GATA3 GATA3 LACC1 LACC1 ENSMNEP00000046151 ENSMNEP00000046151
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD74CD74 molecule. (294 aa)
TRILTLR4 interactor with leucine rich repeats. (811 aa)
TNFRSF14TNF receptor superfamily member 14. (280 aa)
CD81Tetraspanin. (274 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (697 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (592 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
ENSMNEP00000007269VPS9 domain-containing protein. (363 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
CD55CD55 molecule (Cromer blood group). (551 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
LOC105474889AIG1-type G domain-containing protein. (307 aa)
DDX1DEAD-box helicase 1. (740 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
RTN4Reticulon. (1118 aa)
GPRC5BG protein-coupled receptor class C group 5 member B. (421 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
CLNKCytokine dependent hematopoietic cell linker. (443 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
DDX50Uncharacterized protein. (707 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
DDX21DExD-box helicase 21. (783 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
CD226CD226 molecule. (316 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
KIR3DL3Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3. (316 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (126 aa)
INAVAInnate immunity activator. (703 aa)
ENSMNEP00000019591Uncharacterized protein. (83 aa)
LITAFLipopolysaccharide induced TNF factor. (161 aa)
BCL6BCL6 transcription repressor. (708 aa)
SPON2Spondin 2. (331 aa)
SIRT1Sirtuin 1. (743 aa)
ENSMNEP00000022134Helicase C-terminal domain-containing protein. (315 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
ENSMNEP00000023924MHC_I-like_Ag-recog domain-containing protein. (162 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
FOXP3Forkhead box P3. (456 aa)
BST2Bone marrow stromal cell antigen 2. (182 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
TBX21T-box transcription factor 21. (535 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
BTKTyrosine-protein kinase. (659 aa)
APOA2Apolipoprotein A2. (132 aa)
SYKTyrosine-protein kinase. (629 aa)
IFNB1Interferon beta 1. (187 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
EPXEosinophil peroxidase. (715 aa)
KIR2DL4Uncharacterized protein. (416 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
ARG1Arginase. (322 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
DENND1BDENN domain containing 1B. (790 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CD96CD96 molecule. (552 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (440 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
DHX36DEAH-box helicase 36. (1008 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
SPHK2Sphingosine kinase 2. (653 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
NLRX1NLR family member X1. (972 aa)
JAK3Tyrosine-protein kinase. (1088 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
MALT1MALT1 paracaspase. (824 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
ANGPT1Angiopoietin 1. (498 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CUEDC2CUE domain containing 2. (292 aa)
DDX58DExD/H-box helicase 58. (925 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CD160CD160 molecule. (181 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RABGEF1A20-type domain-containing protein. (469 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (992 aa)
GATA3GATA binding protein 3. (444 aa)
LACC1Uncharacterized protein. (430 aa)
ENSMNEP00000046151Helicase C-terminal domain-containing protein. (633 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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