19 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	FGR	Tyrosine-protein kinase. (529 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (311 aa)
	SRC	Tyrosine-protein kinase. (644 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	RHBDF2	Rhomboid 5 homolog 2. (836 aa)
	NLRP6	NLR family pyrin domain containing 6. (1044 aa)
	MKRN2	Makorin ring finger protein 2. (416 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1044 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	YES1	Tyrosine-protein kinase. (548 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	SYK	Tyrosine-protein kinase. (629 aa)
	SELENOS	Selenoprotein S. (190 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	GPR17	G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGR	LYN	ENSMNEP00000041697	ENSMNEP00000037491	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.862
FGR	SRC	ENSMNEP00000041697	ENSMNEP00000006319	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.685
FGR	SYK	ENSMNEP00000041697	ENSMNEP00000028664	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.530
FGR	YES1	ENSMNEP00000041697	ENSMNEP00000022029	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.684
FYN	LYN	ENSMNEP00000008022	ENSMNEP00000037491	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.998
FYN	PLCG1	ENSMNEP00000008022	ENSMNEP00000039772	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.534
FYN	SRC	ENSMNEP00000008022	ENSMNEP00000006319	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.999
FYN	SYK	ENSMNEP00000008022	ENSMNEP00000028664	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.713
FYN	YES1	ENSMNEP00000008022	ENSMNEP00000022029	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.999
IL10	NOD2	ENSMNEP00000036763	ENSMNEP00000017054	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Nucleotide binding oligomerization domain containing 2.	0.503
LYN	FGR	ENSMNEP00000037491	ENSMNEP00000041697	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.862
LYN	FYN	ENSMNEP00000037491	ENSMNEP00000008022	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.998
LYN	PLCG1	ENSMNEP00000037491	ENSMNEP00000039772	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.623
LYN	SRC	ENSMNEP00000037491	ENSMNEP00000006319	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.814
LYN	SYK	ENSMNEP00000037491	ENSMNEP00000028664	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.976
LYN	YES1	ENSMNEP00000037491	ENSMNEP00000022029	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.696
NOD2	IL10	ENSMNEP00000017054	ENSMNEP00000036763	Nucleotide binding oligomerization domain containing 2.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.503
PLCG1	FYN	ENSMNEP00000039772	ENSMNEP00000008022	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.534
PLCG1	LYN	ENSMNEP00000039772	ENSMNEP00000037491	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.623
PLCG1	SRC	ENSMNEP00000039772	ENSMNEP00000006319	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Tyrosine-protein kinase.	0.595