STRINGSTRING
SEMA4D SEMA4D IL1B IL1B EZR EZR LRG1 LRG1 ADD2 ADD2 TNF TNF ROCK1 ROCK1 SYK SYK JAM2 JAM2 PECAM1 PECAM1 ZAP70 ZAP70 ITGA5 ITGA5 PODXL2 PODXL2 F11R F11R VCAM1 VCAM1 FERMT3 FERMT3 S100A9 S100A9 RAC2 RAC2 CD209 CD209 SELL SELL SELE SELE CX3CR1 CX3CR1 ITGB2 ITGB2 PTPRC PTPRC ITGB7 ITGB7 NT5E NT5E STK10 STK10 MADCAM1 MADCAM1 CD177 CD177 OLR1 OLR1 SLC39A8 SLC39A8 CD44 CD44 TNIP1 TNIP1 SPN SPN BMP7 BMP7 GCNT1 GCNT1 EXT1 EXT1 ITGA4 ITGA4 ITGAL ITGAL S100A8 S100A8 CALCA CALCA MSN MSN CERCAM CERCAM UMOD UMOD SELP SELP GOLPH3 GOLPH3 ENSMNEP00000033549 ENSMNEP00000033549
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
EZREzrin. (603 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (383 aa)
ADD2Adducin 2. (726 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
SYKTyrosine-protein kinase. (629 aa)
JAM2Junctional adhesion molecule 2. (311 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (717 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
PODXL2Podocalyxin like 2. (609 aa)
F11RF11 receptor. (328 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
FERMT3Fermitin family member 3. (664 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
RAC2Rac family small GTPase 2. (192 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (413 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)
SELESelectin E. (612 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
ITGB2Integrin beta. (921 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
STK10Serine/threonine kinase 10. (934 aa)
MADCAM1Mucosal vascular addressin cell adhesion molecule 1. (384 aa)
CD177CD177 molecule. (437 aa)
OLR1Oxidized low density lipoprotein receptor 1. (291 aa)
SLC39A8Solute carrier family 39 member 8. (460 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
TNIP1TNFAIP3 interacting protein 1. (620 aa)
SPNSialophorin. (405 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1123 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
MSNMoesin. (577 aa)
CERCAMCerebral endothelial cell adhesion molecule. (488 aa)
UMODUromodulin. (641 aa)
SELPSelectin P. (830 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
ENSMNEP00000033549Uncharacterized protein. (168 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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