STRINGSTRING
PIGR PIGR SOCS5 SOCS5 PTPN11 PTPN11 ERBIN ERBIN EGFR EGFR BRAF BRAF GAREM1 GAREM1 SRC SRC FAM83A FAM83A REPS2 REPS2 ABL1 ABL1 HBEGF HBEGF KIF16B KIF16B RASSF2 RASSF2 ENSMNEP00000012679 ENSMNEP00000012679 PLCE1 PLCE1 EPGN EPGN ADAM17 ADAM17 IQGAP1 IQGAP1 CBL CBL SLC30A10 SLC30A10 ENSMNEP00000016378 ENSMNEP00000016378 GAB1 GAB1 PTK2B PTK2B EGF EGF PIK3CA PIK3CA GAREM2 GAREM2 BTC BTC GRB7 GRB7 VIL1 VIL1 FAM83B FAM83B PTK2 PTK2 BCAR1 BCAR1 SHC3 SHC3 AKT1 AKT1 AREG AREG GRB2 GRB2 ENSMNEP00000027695 ENSMNEP00000027695 TGFA TGFA ENSMNEP00000028330 ENSMNEP00000028330 CAMLG CAMLG NCK2 NCK2 EREG EREG SHC1 SHC1 ERBB4 ERBB4 SOX9 SOX9 PLCG1 PLCG1 TGFB1 TGFB1 EFEMP1 EFEMP1 SOS1 SOS1 DGKD DGKD ERBB2 ERBB2 PDPK1 PDPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIGRPolymeric immunoglobulin receptor. (764 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ERBINErbb2 interacting protein. (1418 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (876 aa)
SRCTyrosine-protein kinase. (644 aa)
FAM83AFamily with sequence similarity 83 member A. (434 aa)
REPS2RALBP1 associated Eps domain containing 2. (652 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
KIF16BKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1392 aa)
RASSF2Ras association domain family member 2. (326 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
PLCE1Phosphoinositide phospholipase C. (2295 aa)
EPGNEpithelial mitogen. (154 aa)
ADAM17ADAM metallopeptidase domain 17. (803 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1627 aa)
CBLCbl proto-oncogene. (907 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1166 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (854 aa)
BTCBetacellulin. (145 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
VIL1Villin 1. (830 aa)
FAM83BFamily with sequence similarity 83 member B. (1011 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
SHC3SHC adaptor protein 3. (598 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AREGAmphiregulin. (274 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSMNEP00000028330Uncharacterized protein. (60 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
NCK2Cytoplasmic protein. (382 aa)
EREGEpiregulin. (169 aa)
SHC1SHC adaptor protein 1. (584 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
SOX9SRY-box transcription factor 9. (509 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1314 aa)
DGKDDiacylglycerol kinase. (1216 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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