STRINGSTRING
ITGB6 ITGB6 USP15 USP15 FURIN FURIN FERMT2 FERMT2 PARP1 PARP1 TGFBRAP1 TGFBRAP1 APPL1 APPL1 STAT3 STAT3 SMAD3 SMAD3 BMPR1A BMPR1A CITED1 CITED1 CHST11 CHST11 ZYX ZYX COL1A2 COL1A2 TGFBR1 TGFBR1 FOS FOS LOC105493395 LOC105493395 COL3A1 COL3A1 SMAD4 SMAD4 FOXH1 FOXH1 TWSG1 TWSG1 SKIL SKIL GDF5 GDF5 FUT8 FUT8 MSTN MSTN SRC SRC CLDN5 CLDN5 SMAD1 SMAD1 ADAM9 ADAM9 FLCN FLCN EID2 EID2 LOC105493392 LOC105493392 ITGA8 ITGA8 TGFBR3L TGFBR3L SKI SKI MTMR4 MTMR4 LTBP4 LTBP4 TGFB3 TGFB3 TGFB2 TGFB2 ITGB5 ITGB5 PML PML TGFB1 TGFB1 CDH5 CDH5 AMHR2 AMHR2 SMAD5 SMAD5 LTBP3 LTBP3 ZMIZ1 ZMIZ1 LRRC32 LRRC32 PTPRK PTPRK NRROS NRROS TGFBR2 TGFBR2 HPGD HPGD APPL2 APPL2 SMAD7 SMAD7 ID1 ID1 WFIKKN2 WFIKKN2 HIPK2 HIPK2 NLK NLK ONECUT2 ONECUT2 CITED2 CITED2 PXN PXN ACVRL1 ACVRL1 FNTA FNTA ENSMNEP00000028413 ENSMNEP00000028413 ZFYVE9 ZFYVE9 ITGB8 ITGB8 SMAD2 SMAD2 FMOD FMOD ACVR1 ACVR1 GLG1 GLG1 USP9X USP9X GDF10 GDF10 LPXN LPXN NODAL NODAL GCNT2 GCNT2 LTBP2 LTBP2 GCNT2-2 GCNT2-2 DUSP22 DUSP22 PTK2 PTK2 BAMBI BAMBI TGFBR3 TGFBR3 ENG ENG SMAD9 SMAD9 SIRT1 SIRT1 SMAD6 SMAD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
FERMT2Fermitin family member 2. (689 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (861 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
ZYXZyxin. (572 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC105493395Uncharacterized protein. (905 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FOXH1Forkhead box H1. (366 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (237 aa)
SKILSKI like proto-oncogene. (684 aa)
GDF5Growth differentiation factor 5. (499 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
MSTNMyostatin. (375 aa)
SRCTyrosine-protein kinase. (644 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ADAM9ADAM metallopeptidase domain 9. (816 aa)
FLCNFolliculin. (579 aa)
EID2EP300 interacting inhibitor of differentiation 2. (236 aa)
LOC105493392Uncharacterized protein. (825 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1063 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (314 aa)
SKISKI proto-oncogene. (728 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1608 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
PMLPromyelocytic leukemia. (882 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (785 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (572 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1298 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1073 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1353 aa)
NRROSNegative regulator of reactive oxygen species. (732 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (786 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
ONECUT2One cut domain family member. (429 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
PXNPaxillin. (1082 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (379 aa)
ENSMNEP00000028413Uncharacterized protein. (313 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
ITGB8Integrin beta. (421 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FMODFibromodulin. (376 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GLG1Golgi glycoprotein 1. (1042 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2584 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
NODALNodal growth differentiation factor. (347 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (351 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1821 aa)
GCNT2-2Uncharacterized protein. (409 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1054 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
ENGEndoglin. (658 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
SIRT1Sirtuin 1. (743 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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