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| | AK5 | Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa) |
| | ENSMNEP00000008691 | dUTPase domain-containing protein. (136 aa) |
| | UPRT | Uracil phosphoribosyltransferase homolog. (309 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | NT5DC1 | 5'-nucleotidase domain containing 1. (455 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | GMPS | Guanine monophosphate synthase. (661 aa) |
| | XDH | Xanthine dehydrogenase. (1333 aa) |
| | NUDT2 | Nudix hydrolase domain-containing protein. (147 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (627 aa) |
| | IMPDH | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (634 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (314 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2242 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (232 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (371 aa) |
| | ENSMNEP00000015921 | Uncharacterized protein. (554 aa) |
| | ADA | Adenosine deaminase. (449 aa) |
| | ENSMNEP00000017753 | Uncharacterized protein. (437 aa) |
| | DPYS | Dihydropyrimidinase. (519 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (975 aa) |
| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (178 aa) |
| | ENSMNEP00000019144 | IMPDH domain-containing protein. (465 aa) |
| | ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (592 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (471 aa) |
| | TK2 | Thymidine kinase 2. (281 aa) |
| | MAGI3 | Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1482 aa) |
| | AK7 | Adenylate kinase 7. (652 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (220 aa) |
| | AK4 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (161 aa) |
| | ENSMNEP00000023472 | Uncharacterized protein. (66 aa) |
| | ENSMNEP00000024164 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (155 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (468 aa) |
| | ENSMNEP00000024948 | Flavokinase domain-containing protein. (153 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | PRPS1 | Pribosyltran_N domain-containing protein. (318 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (497 aa) |
| | UCK1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa) |
| | RFK | Flavokinase domain-containing protein. (162 aa) |
| | UMPS | Uridine monophosphate synthetase. (480 aa) |
| | NT5C2 | 5'-nucleotidase, cytosolic II. (572 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | TK1 | Thymidine kinase. (261 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (879 aa) |
| | ENSMNEP00000028510 | Uncharacterized protein; Belongs to the IMPDH/GMPR family. (458 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa) |
| | DGUOK | Deoxyguanosine kinase. (277 aa) |
| | TYMS | Thymidylate synthetase. (313 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (351 aa) |
| | ENSMNEP00000033027 | CBS domain-containing protein. (458 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (363 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (747 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1299 aa) |
| | AK9 | Adenylate kinase 9. (1914 aa) |
| | AK3 | Adenylate kinase 3; Belongs to the adenylate kinase family. (215 aa) |
| | NT5DC4 | 5'-nucleotidase domain containing 4. (389 aa) |
| | DUT | dUTPase domain-containing protein. (252 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | NT5M | 5',3'-nucleotidase, mitochondrial. (228 aa) |
| | UPB1 | Beta-ureidopropionase 1. (386 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (201 aa) |
| | ENSMNEP00000041095 | Pribosyltran_N domain-containing protein. (273 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (784 aa) |
| | PAICS | AIRC domain-containing protein. (436 aa) |
| | LRGUK | Leucine rich repeats and guanylate kinase domain containing. (794 aa) |
| | ENSMNEP00000043008 | Pribosyltran_N domain-containing protein. (196 aa) |
| | ADK | Adenosine kinase. (362 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (947 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | TYMP | Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa) |
| | ADSS1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (499 aa) |
| | PRPS2 | Pribosyltran_N domain-containing protein. (318 aa) |
| | GUK1 | Guanylate kinase 1. (272 aa) |
| | DCK | Deoxycytidine kinase. (317 aa) |
| | DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (237 aa) |
| | DTYMK | Deoxythymidylate kinase. (212 aa) |
| | ENSMNEP00000005597 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (209 aa) |
| | ENSMNEP00000005163 | dUTPase domain-containing protein. (66 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (422 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (555 aa) |
| | ENSMNEP00000002186 | Uncharacterized protein. (402 aa) |
| | ENSMNEP00000002012 | dUTPase domain-containing protein. (159 aa) |
| | ENSMNEP00000001932 | ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (228 aa) |
| | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | ENSMNEP00000000038 | Nudix hydrolase domain-containing protein. (147 aa) |
