STRINGSTRING
SPG7 SPG7 LOC105493689 LOC105493689 TYSND1 TYSND1 HJV HJV BAD BAD HTRA2 HTRA2 MME MME CTSH CTSH BACE1 BACE1 DISP1 DISP1 PRSS12 PRSS12 ADAM19 ADAM19 STOML2 STOML2 OMA1 OMA1 PCSK7 PCSK7 ADAMTS3 ADAMTS3 NCSTN NCSTN C2CD3 C2CD3 ECEL1 ECEL1 DYNC2H1 DYNC2H1 PCSK2 PCSK2 CASP2 CASP2 IHH IHH CTSL CTSL MEP1A MEP1A SHH SHH F12 F12 RIPK2 RIPK2 CPXM2 CPXM2 ATP23 ATP23 CPN1 CPN1 PYCARD PYCARD ECE2 ECE2 OGT OGT SEC11C SEC11C PRR14L PRR14L ADAM10 ADAM10 CD5L CD5L PLA2G7 PLA2G7 MYRF MYRF SPCS2 SPCS2 F11 F11 TBC1D10A TBC1D10A YIPF5 YIPF5 BACE2 BACE2 LGMN LGMN CASP8 CASP8 YME1L1 YME1L1 PTCH1 PTCH1 ENSMNEP00000031177 ENSMNEP00000031177 FGG FGG FAM111A FAM111A PSENEN PSENEN IFI16 IFI16 SDE2 SDE2 IFT172 IFT172 PERP PERP ENSMNEP00000030000 ENSMNEP00000030000 ZMPSTE24 ZMPSTE24 FADD FADD KEL KEL IMMP2L IMMP2L F10 F10 PLAU PLAU PSEN1 PSEN1 GLG1 GLG1 COMP COMP PMPCA PMPCA DPP4 DPP4 P2RX7 P2RX7 CNTN2 CNTN2 CASP7 CASP7 SPCS3 SPCS3 FGB FGB BMP1 BMP1 CTSZ CTSZ PCSK9 PCSK9 MBTPS1 MBTPS1 PCSK1N PCSK1N PSEN2 PSEN2 IL1R2 IL1R2 METAP2 METAP2 PIK3C3 PIK3C3 SPON1 SPON1 REN REN CPD CPD MMEL1 MMEL1 PPP2R5C PPP2R5C APH1B APH1B CTSS CTSS FGA FGA CTSE CTSE FXN FXN ADAMTS13 ADAMTS13 FURIN FURIN HM13 HM13 APH1A APH1A PARP1 PARP1 CPXM1 CPXM1 MYRFL MYRFL PISD PISD F5 F5 CUZD1 CUZD1 CTSG CTSG ENSMNEP00000019922 ENSMNEP00000019922 SLC30A5 SLC30A5 APOH APOH F8 F8 LONP2 LONP2 CPA3 CPA3 DHH DHH F3 F3 ENPEP ENPEP CASP9 CASP9 ADAMTS2 ADAMTS2 ENSMNEP00000016390 ENSMNEP00000016390 TMPRSS4 TMPRSS4 ENSMNEP00000016004 ENSMNEP00000016004 ERO1A ERO1A TMPRSS12 TMPRSS12 LOC105493395 LOC105493395 CPZ CPZ ENSMNEP00000013845 ENSMNEP00000013845 ADAM17 ADAM17 ACE ACE ECE1 ECE1 SPPL3 SPPL3 MMP14 MMP14 VSIR VSIR APAF1 APAF1 PHEX PHEX C1RL C1RL ASPH ASPH SPRTN SPRTN BAK1 BAK1 CPLANE2 CPLANE2 MBOAT4 MBOAT4 NLRP6 NLRP6 SLC30A8 SLC30A8 TMPRSS2 TMPRSS2 SLC30A6 SLC30A6 TLL1 TLL1 SPCS1 SPCS1 PIDD1 PIDD1 SCG5 SCG5 KLK6 KLK6 CASP6 CASP6 SRGN SRGN XPNPEP3 XPNPEP3 ENSMNEP00000007520 ENSMNEP00000007520 PCSK1 PCSK1 PMPCB PMPCB PCSK4 PCSK4 CASP4 CASP4 ASPRV1 ASPRV1 PCSK5 PCSK5 ADAM9 ADAM9 PLAT PLAT HGFAC HGFAC CIDEB CIDEB SEC11A SEC11A GLI3 GLI3 FKRP FKRP KLK13 KLK13 AFG3L2 AFG3L2 CORIN CORIN LOC105482287 LOC105482287 F9 F9 RCE1 RCE1 CASP1 CASP1 ATP6AP2 ATP6AP2 PAWR PAWR MMP16 MMP16 PCSK6 PCSK6 LOC105493392 LOC105493392 ENSMNEP00000000624 ENSMNEP00000000624 IMMP1L IMMP1L ENSMNEP00000000191 ENSMNEP00000000191 TLL2 TLL2 TMEM208 TMEM208
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPG7SPG7 matrix AAA peptidase subunit, paraplegin. (770 aa)
LOC105493689Uncharacterized protein; Belongs to the peptidase C14A family. (410 aa)
TYSND1Trypsin domain containing 1. (566 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
BADBCL2 associated agonist of cell death. (167 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MMEMembrane metalloendopeptidase. (750 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
DISP1Dispatched RND transporter family member 1. (1523 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
ADAM19ADAM metallopeptidase domain 19. (918 aa)
STOML2Stomatin like 2. (356 aa)
OMA1OMA1 zinc metallopeptidase. (524 aa)
PCSK7Proprotein convertase subtilisin/kexin type 7. (786 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3. (1205 aa)
NCSTNNicastrin. (721 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2325 aa)
ECEL1Endothelin converting enzyme like 1. (775 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
PCSK2Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (638 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (341 aa)
MEP1AMeprin A subunit. (746 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
F12Coagulation factor XII. (615 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
CPXM2Carboxypeptidase X, M14 family member 2. (756 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
CPN1Carboxypeptidase N subunit 1. (393 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ECE2EEF1AKMT4-ECE2 readthrough. (853 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
PRR14LProline rich 14 like. (2150 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
CD5LCD5 molecule like. (347 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (439 aa)
MYRFMyelin regulatory factor. (1152 aa)
SPCS2Signal peptidase complex subunit 2. (257 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (625 aa)
TBC1D10ATBC1 domain family member 10A. (508 aa)
YIPF5Protein YIPF. (257 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (518 aa)
LGMNLegumain. (433 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (487 aa)
YME1L1YME1 like 1 ATPase. (735 aa)
PTCH1Patched 1. (1449 aa)
ENSMNEP00000031177Uncharacterized protein. (220 aa)
FGGFibrinogen gamma chain. (437 aa)
FAM111AFamily with sequence similarity 111 member A. (611 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
IFI16Interferon gamma inducible protein 16. (729 aa)
SDE2SDE2 telomere maintenance homolog. (451 aa)
IFT172Intraflagellar transport 172. (1744 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
ENSMNEP00000030000Uncharacterized protein. (126 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (490 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
KELKell metallo-endopeptidase (Kell blood group). (732 aa)
IMMP2LMitochondrial inner membrane protease subunit. (175 aa)
F10Coagulation factor X. (488 aa)
PLAUPlasminogen activator, urokinase. (429 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
GLG1Golgi glycoprotein 1. (1042 aa)
COMPCartilage oligomeric matrix protein. (716 aa)
PMPCAPeptidase, mitochondrial processing alpha subunit; Belongs to the peptidase M16 family. (545 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CNTN2Contactin 2. (1040 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (377 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
FGBFibrinogen beta chain. (491 aa)
BMP1Metalloendopeptidase. (986 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (811 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1052 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (261 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (481 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (478 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
SPON1Spondin 1. (934 aa)
RENRenin; Belongs to the peptidase A1 family. (406 aa)
CPDCarboxypeptidase D. (1378 aa)
MMEL1Membrane metalloendopeptidase like 1. (779 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (533 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (331 aa)
FGAFibrinogen alpha chain. (862 aa)
CTSECathepsin E; Belongs to the peptidase A1 family. (396 aa)
FXNFrataxin. (210 aa)
ADAMTS13ADAM metallopeptidase with thrombospondin type 1 motif 13. (1429 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
HM13Histocompatibility minor 13. (394 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
CPXM1Carboxypeptidase X, M14 family member 1. (732 aa)
MYRFLMyelin regulatory factor like. (910 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2172 aa)
CUZD1Uncharacterized protein. (607 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
ENSMNEP00000019922Uncharacterized protein. (144 aa)
SLC30A5Solute carrier family 30 member 5. (774 aa)
APOHApolipoprotein H. (342 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2351 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
CPA3Carboxypeptidase A3. (417 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
F3Coagulation factor III, tissue factor. (296 aa)
ENPEPAminopeptidase. (957 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (421 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1209 aa)
ENSMNEP00000016390Uncharacterized protein. (208 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)
ENSMNEP00000016004AAA domain-containing protein. (732 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (468 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (348 aa)
LOC105493395Uncharacterized protein. (905 aa)
CPZCarboxypeptidase Z. (652 aa)
ENSMNEP00000013845Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (436 aa)
ADAM17ADAM metallopeptidase domain 17. (803 aa)
ACEAngiotensin-converting enzyme. (1160 aa)
ECE1Endothelin converting enzyme 1. (771 aa)
SPPL3Signal peptide peptidase like 3. (384 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (749 aa)
C1RLComplement C1r subcomponent like. (433 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
SPRTNSprT-like N-terminal domain. (488 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
MBOAT4Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (435 aa)
NLRP6NLR family pyrin domain containing 6. (1044 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
SLC30A6Solute carrier family 30 member 6. (461 aa)
TLL1Metalloendopeptidase. (1036 aa)
SPCS1Signal peptidase complex subunit 1. (169 aa)
PIDD1P53-induced death domain protein 1. (936 aa)
SCG5Secretogranin V. (212 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (244 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
SRGNSerglycin. (153 aa)
XPNPEP3X-prolyl aminopeptidase 3. (507 aa)
ENSMNEP00000007520CARD domain-containing protein. (359 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
PMPCBPeptidase, mitochondrial processing beta subunit; Belongs to the peptidase M16 family. (493 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (640 aa)
CASP4Caspase 4; Belongs to the peptidase C14A family. (377 aa)
ASPRV1Aspartic peptidase retroviral like 1. (343 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1887 aa)
ADAM9ADAM metallopeptidase domain 9. (816 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
HGFACHGF activator. (657 aa)
CIDEBCell death inducing DFFA like effector b. (219 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (188 aa)
GLI3GLI family zinc finger 3. (1580 aa)
FKRPFukutin related protein. (495 aa)
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (277 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (727 aa)
CORINCorin, serine peptidase. (1019 aa)
LOC105482287Signal peptidase complex catalytic subunit SEC11. (156 aa)
F9Coagulation factor IX. (461 aa)
RCE1Ras converting CAAX endopeptidase 1. (329 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (442 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
PAWRPro-apoptotic WT1 regulator. (342 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (938 aa)
LOC105493392Uncharacterized protein. (825 aa)
ENSMNEP00000000624Uncharacterized protein. (57 aa)
IMMP1LMitochondrial inner membrane protease subunit. (166 aa)
ENSMNEP00000000191Uncharacterized protein. (61 aa)
TLL2Metalloendopeptidase. (1015 aa)
TMEM208Transmembrane protein 208. (173 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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