STRINGSTRING
ANK3 ANK3 CHERP CHERP PLN PLN ENSMNEP00000002118 ENSMNEP00000002118 RYR2 RYR2 PLEC PLEC SERTAD1 SERTAD1 MRLN MRLN PBDC1 PBDC1 SRL SRL ITPR2 ITPR2 CACNA1S CACNA1S SLN SLN P3H2 P3H2 THBS4 THBS4 RASD1 RASD1 ELAVL1 ELAVL1 CACNA2D1 CACNA2D1 CASQ2 CASQ2 CASQ1 CASQ1 JSRP1 JSRP1 CALU CALU SGCD SGCD SRI SRI XDH XDH ASPH ASPH NOL3 NOL3 HABP4 HABP4 TMEM38B TMEM38B MANF MANF ATP2A2 ATP2A2 DHRS7C DHRS7C RYR3 RYR3 ENSMNEP00000017745 ENSMNEP00000017745 HRC HRC CCDC78 CCDC78 AGL AGL ENSMNEP00000019763 ENSMNEP00000019763 HSP90B1 HSP90B1 CALR CALR RTN2 RTN2 STRIT1 STRIT1 RYR1 RYR1 SLC2A4 SLC2A4 TRDN TRDN FSD2 FSD2 ITPR1 ITPR1 NOS1 NOS1 ART1 ART1 ENSMNEP00000024989 ENSMNEP00000024989 TMEM109 TMEM109 NOS1AP NOS1AP MEF2C MEF2C HK2 HK2 JPH3 JPH3 ITPR3 ITPR3 JPH4 JPH4 DMPK DMPK CMYA5 CMYA5 LOC105481475 LOC105481475 GSN GSN STIM1 STIM1 CTHRC1 CTHRC1 ATP2A1 ATP2A1 MRVI1 MRVI1 KLHL41 KLHL41 CAMK2B CAMK2B SPOCK1 SPOCK1 AKAP6 AKAP6 ANK1 ANK1 ENSMNEP00000034665 ENSMNEP00000034665 SLC8A3 SLC8A3 S100A1 S100A1 CAMK2G CAMK2G POMT1 POMT1 ATP2A3 ATP2A3 HAX1 HAX1 JPH1 JPH1 THBS1 THBS1 CAVIN4 CAVIN4 JPH2 JPH2 SERPINB5 SERPINB5 TMEM38A TMEM38A DTNBP1 DTNBP1 FKBP1B FKBP1B SCN3A SCN3A IFRD1 IFRD1 MTMR12 MTMR12 REEP5 REEP5 BAALC BAALC CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANK3Ankyrin 3. (4377 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (927 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ENSMNEP00000002118Uncharacterized protein. (381 aa)
RYR2Ryanodine receptor 2. (4951 aa)
PLECPlectin. (4774 aa)
SERTAD1SERTA domain containing 1. (236 aa)
MRLNMyoregulin. (46 aa)
PBDC1Polysaccharide biosynthesis domain containing 1. (233 aa)
SRLDynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1016 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
SLNUncharacterized protein. (31 aa)
P3H2Prolyl 3-hydroxylase 2. (705 aa)
THBS4Thrombospondin 4. (961 aa)
RASD1Ras related dexamethasone induced 1. (279 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (333 aa)
CALUCalumenin. (323 aa)
SGCDSarcoglycan delta. (290 aa)
SRISorcin. (198 aa)
XDHXanthine dehydrogenase. (1333 aa)
ASPHAspartate beta-hydroxylase. (762 aa)
NOL3Nucleolar protein 3. (260 aa)
HABP4Hyaluronan binding protein 4. (405 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (182 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
RYR3Ryanodine receptor 3. (4856 aa)
ENSMNEP00000017745Uncharacterized protein. (58 aa)
HRCHistidine rich calcium binding protein. (701 aa)
CCDC78Coiled-coil domain containing 78. (467 aa)
AGLAmylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1532 aa)
ENSMNEP00000019763Uncharacterized protein. (285 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
CALRCalreticulin. (417 aa)
RTN2Reticulon. (545 aa)
STRIT1Small transmembrane regulator of ion transport 1. (35 aa)
RYR1Ryanodine receptor 1. (4913 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (559 aa)
TRDNTriadin. (725 aa)
FSD2Fibronectin type III and SPRY domain containing 2. (750 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2749 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
ART1NAD(P)(+)--arginine ADP-ribosyltransferase. (361 aa)
ENSMNEP00000024989KASH domain-containing protein. (3507 aa)
TMEM109Transmembrane protein 109. (243 aa)
NOS1APPID domain-containing protein. (695 aa)
MEF2CMyocyte enhancer factor 2C. (486 aa)
HK2Hexokinase 2. (917 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (748 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (628 aa)
DMPKDM1 protein kinase. (630 aa)
CMYA5Cardiomyopathy associated 5. (3937 aa)
LOC105481475Uncharacterized protein. (84 aa)
GSNGelsolin. (759 aa)
STIM1Stromal interaction molecule 1. (790 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1030 aa)
MRVI1Murine retrovirus integration site 1 homolog. (913 aa)
KLHL41Kelch like family member 41. (544 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (439 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
ANK1Ankyrin 1. (1896 aa)
ENSMNEP00000034665Uncharacterized protein. (98 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
S100A1Protein S100; Belongs to the S-100 family. (147 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
POMT1Protein O-mannosyltransferase 1. (737 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1037 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
JPH1Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (661 aa)
THBS1Thrombospondin 1. (1173 aa)
CAVIN4Caveolae associated protein 4. (362 aa)
JPH2Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (696 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
TMEM38ATransmembrane protein 38A. (299 aa)
DTNBP1Dystrobrevin binding protein 1. (350 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
IFRD1Interferon related developmental regulator 1. (451 aa)
MTMR12Myotubularin related protein 12. (743 aa)
REEP5Receptor expression-enhancing protein. (193 aa)
BAALCBAALC binder of MAP3K1 and KLF4. (126 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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