STRINGSTRING
LATS2 LATS2 UHMK1 UHMK1 ATM ATM MKNK2 MKNK2 ATR ATR GRK2 GRK2 STK4 STK4 PRKX PRKX TSSK6 TSSK6 STK39 STK39 RPS6KA3 RPS6KA3 PRKD1 PRKD1 DYRK2 DYRK2 PKN1 PKN1 PAK2 PAK2 DCLK2 DCLK2 AURKA AURKA TLK1 TLK1 PRKAA2 PRKAA2 VRK1 VRK1 CDK5R1 CDK5R1 PRKCB PRKCB ENSMNEP00000005884 ENSMNEP00000005884 CDC7 CDC7 GSK3B GSK3B MARK1 MARK1 CSNK2A1 CSNK2A1 SRC SRC DYRK1A DYRK1A PLK2 PLK2 PRKCQ PRKCQ CSNK2A2 CSNK2A2 BRSK1 BRSK1 IL24 IL24 MORC3 MORC3 AURKB AURKB RPS6KA2 RPS6KA2 SMTNL1 SMTNL1 MAST4 MAST4 DCLK1 DCLK1 TTBK2 TTBK2 RPS6KA6 RPS6KA6 MASTL MASTL MTOR MTOR MAP3K10 MAP3K10 LRRK2 LRRK2 RIPK1 RIPK1 BAK1 BAK1 SLC1A1 SLC1A1 NTRK2 NTRK2 SMG1 SMG1 PRKAA1 PRKAA1 MARK3 MARK3 MAPK1 MAPK1 CAMK1G CAMK1G HIPK3 HIPK3 WNK1 WNK1 CHUK CHUK MAPK8 MAPK8 ULK2 ULK2 CAMK4 CAMK4 TSSK4 TSSK4 STK38L STK38L MAPKAPK5 MAPKAPK5 CAB39 CAB39 LOC105463814 LOC105463814 CLK1 CLK1 PRKG2 PRKG2 MYO3A MYO3A MAPKAPK3 MAPKAPK3 CLSPN CLSPN TGFBR1 TGFBR1 RPS6KA4 RPS6KA4 DYRK4 DYRK4 RPS6KB2 RPS6KB2 PRKCE PRKCE PINK1 PINK1 ENSMNEP00000017273 ENSMNEP00000017273 EIF2AK3 EIF2AK3 DGKQ DGKQ NEK6 NEK6 PKN2 PKN2 CSNK1A1L CSNK1A1L ULK1 ULK1 SRPK2 SRPK2 TTBK1 TTBK1 MAP4K1 MAP4K1 RICTOR RICTOR BCL2 BCL2 SGK2 SGK2 CAMK1 CAMK1 PKN3 PKN3 CSNK1A1 CSNK1A1 ENSMNEP00000025766 ENSMNEP00000025766 AKT1 AKT1 MYO3B MYO3B GAS6 GAS6 ENSMNEP00000027498 ENSMNEP00000027498 MAST2 MAST2 DMPK DMPK DCLK3 DCLK3 MKNK1 MKNK1 HIPK4 HIPK4 SYK SYK PRKCA PRKCA ROCK1 ROCK1 AKT2 AKT2 RPS6KA5 RPS6KA5 PRKCZ PRKCZ LMTK2 LMTK2 PDGFB PDGFB MAP3K12 MAP3K12 GSK3A GSK3A PRKD2 PRKD2 MAST3 MAST3 MAST1 MAST1 STK32C STK32C PCK1 PCK1 SBK1 SBK1 NLK NLK PRKCD PRKCD TOP1 TOP1 HIPK2 HIPK2 TLK2 TLK2 ULK3 ULK3 AURKC AURKC IKBKB IKBKB CAMK1D CAMK1D VRK3 VRK3 EPO EPO TAF1 TAF1 PNCK PNCK MAPK13 MAPK13 MST1 MST1 HIPK1 HIPK1 PRKDC PRKDC PIKFYVE PIKFYVE TGFBR2 TGFBR2 MAPK7 MAPK7 TNKS TNKS MAPK9 MAPK9 MAP3K13 MAP3K13 STK32B STK32B IKBKE IKBKE AKT3 AKT3 VRK2 VRK2 LATS1 LATS1 MAPK12 MAPK12 ENSMNEP00000039662 ENSMNEP00000039662 ENSMNEP00000039751 ENSMNEP00000039751 CHEK2 CHEK2 PRKCI PRKCI PKD1 PKD1 TDGF1 TDGF1 STK32A STK32A MAPK10 MAPK10 RPS6KA1 RPS6KA1 TBK1 TBK1 PBK PBK DYRK1B DYRK1B PLK1 PLK1 CDK1 CDK1 CAMKV CAMKV ROCK2 ROCK2 MAPKAPK2 MAPKAPK2 PDK3 PDK3 CDK2 CDK2 ERN1 ERN1 CDK5 CDK5 BRSK2 BRSK2 ENSMNEP00000044158 ENSMNEP00000044158 CSNK1G1 CSNK1G1 MAP3K20 MAP3K20 RPS6KB1 RPS6KB1 MAPK14 MAPK14 PDPK1 PDPK1 MARK2 MARK2 CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LATS2Non-specific serine/threonine protein kinase. (1086 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
STK4Serine/threonine kinase 4. (491 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (358 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
STK39Serine/threonine kinase 39. (550 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
PKN1Protein kinase N1. (949 aa)
PAK2Non-specific serine/threonine protein kinase. (501 aa)
DCLK2Doublecortin like kinase 2. (783 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
TLK1Protein kinase domain-containing protein. (787 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ENSMNEP00000005884Uncharacterized protein. (479 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (400 aa)
MARK1Non-specific serine/threonine protein kinase. (795 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
SRCTyrosine-protein kinase. (644 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (345 aa)
BRSK1BR serine/threonine kinase 1. (734 aa)
IL24Interleukin 24. (207 aa)
MORC3MORC family CW-type zinc finger 3. (910 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (378 aa)
RPS6KA2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (723 aa)
SMTNL1Smoothelin like 1. (497 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2623 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
TTBK2Tau tubulin kinase 2; Belongs to the intermediate filament family. (1505 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
MASTLMicrotubule associated serine/threonine kinase like. (879 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (952 aa)
LRRK2Leucine rich repeat kinase 2. (2512 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (693 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MARK3Non-specific serine/threonine protein kinase. (770 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
WNK1OSR1_C domain-containing protein. (2398 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1035 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
STK38LNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (464 aa)
MAPKAPK5MAPK activated protein kinase 5. (474 aa)
CAB39Calcium binding protein 39. (341 aa)
LOC105463814Protein kinase domain-containing protein. (393 aa)
CLK1CDC like kinase 1. (596 aa)
PRKG2cGMP-dependent protein kinase. (814 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1623 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
CLSPNClaspin. (1342 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (649 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (634 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PINK1PTEN induced kinase 1. (581 aa)
ENSMNEP00000017273Protein kinase domain-containing protein. (311 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
DGKQDiacylglycerol kinase. (957 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (347 aa)
PKN2Protein kinase N2. (983 aa)
CSNK1A1LCasein kinase 1 alpha 1 like. (243 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
SRPK2SRSF protein kinase 2. (687 aa)
TTBK1Tau tubulin kinase 1. (1324 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (816 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
PKN3Protein kinase N3. (891 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa)
ENSMNEP00000025766CFC domain-containing protein. (170 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1341 aa)
GAS6Growth arrest specific 6. (683 aa)
ENSMNEP00000027498Protein kinase domain-containing protein. (457 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1747 aa)
DMPKDM1 protein kinase. (630 aa)
DCLK3Doublecortin like kinase 3. (817 aa)
MKNK1MAPK interacting serine/threonine kinase 1. (520 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
SYKTyrosine-protein kinase. (629 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPS6KA5Ribosomal protein S6 kinase. (802 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
LMTK2Lemur tyrosine kinase 2. (1502 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1331 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1571 aa)
STK32CSerine/threonine kinase 32C; Belongs to the protein kinase superfamily. (485 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
SBK1Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (424 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PRKCDProtein kinase C. (729 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
TLK2Tousled like kinase 2. (750 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (385 aa)
VRK3VRK serine/threonine kinase 3. (484 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
TAF1Transcription initiation factor TFIID subunit. (1875 aa)
PNCKPregnancy up-regulated nonubiquitous CaM kinase; Belongs to the protein kinase superfamily. (360 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
MAPK9Mitogen-activated protein kinase 9. (354 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13. (939 aa)
STK32BSerine/threonine kinase 32B. (327 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VRK2VRK serine/threonine kinase 2. (507 aa)
LATS1Large tumor suppressor kinase 1. (1129 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ENSMNEP00000039662Protein kinase domain-containing protein. (539 aa)
ENSMNEP00000039751Uncharacterized protein. (123 aa)
CHEK2Checkpoint kinase 2. (588 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4303 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
STK32ASerine/threonine kinase 32A; Belongs to the protein kinase superfamily. (400 aa)
MAPK10Mitogen-activated protein kinase. (489 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
TBK1TANK binding kinase 1. (729 aa)
PBKPDZ binding kinase. (323 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CAMKVCaM kinase like vesicle associated. (501 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (978 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
BRSK2BR serine/threonine kinase 2. (759 aa)
ENSMNEP00000044158Protein kinase domain-containing protein. (279 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (467 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (908 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (582 aa)
MARK2Non-specific serine/threonine protein kinase. (788 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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