STRINGSTRING
BDNF BDNF CDKL5 CDKL5 ADNP2 ADNP2 IGF1 IGF1 CYFIP1 CYFIP1 COMMD5 COMMD5 SLC9A1 SLC9A1 TRIM32 TRIM32 SEMA7A SEMA7A RPS6KA3 RPS6KA3 H1-5 H1-5 SUPV3L1 SUPV3L1 SPHK1 SPHK1 NOL12 NOL12 RPTOR RPTOR CDH4 CDH4 CIB1 CIB1 TEAD1 TEAD1 SHTN1 SHTN1 EGFR EGFR DNPH1 DNPH1 IL9 IL9 PLAA PLAA CSNK2A1 CSNK2A1 SFN SFN TRPC5 TRPC5 PRKN PRKN ANAPC2 ANAPC2 RASAL1 RASAL1 LOC105469173 LOC105469173 LPAR3 LPAR3 MFSD2A MFSD2A GOLGA4 GOLGA4 NTN1 NTN1 EDN1 EDN1 ENSMNEP00000008392 ENSMNEP00000008392 EFNA5 EFNA5 CXCL12 CXCL12 TRPV2 TRPV2 MEGF8 MEGF8 MTOR MTOR HBEGF HBEGF EXOSC9 EXOSC9 LOC105476302 LOC105476302 SLC23A2 SLC23A2 DDX49 DDX49 CACNG7 CACNG7 FN1 FN1 DBN1 DBN1 RNF157 RNF157 MAP1B MAP1B KLHL22 KLHL22 RIMS2 RIMS2 SMURF1 SMURF1 SYT1 SYT1 MMP14 MMP14 ENSMNEP00000013458 ENSMNEP00000013458 KDM2B KDM2B ADAM17 ADAM17 N6AMT1 N6AMT1 RND2 RND2 BRAT1 BRAT1 ENSMNEP00000015048 ENSMNEP00000015048 TGFBR1 TGFBR1 DDX3X DDX3X EXOSC2 EXOSC2 YAP1 YAP1 CDKN2AIP CDKN2AIP RIMS1 RIMS1 CPNE9 CPNE9 BMPR2 BMPR2 PTK2B PTK2B SEMA4D SEMA4D CPNE5 CPNE5 S100A9 S100A9 EXOSC4 EXOSC4 PRR5 PRR5 DISC1 DISC1 AVPR1A AVPR1A IGFBP1 IGFBP1 FXN FXN HDGFL2 HDGFL2 INO80 INO80 MACF1 MACF1 ENSMNEP00000023008 ENSMNEP00000023008 RICTOR RICTOR BCL2 BCL2 POU4F2 POU4F2 LGI1 LGI1 AKT1 AKT1 PARP2 PARP2 LOC105497839 LOC105497839 HYAL1 HYAL1 ITSN2 ITSN2 SFRP1 SFRP1 AVP AVP RUFY3 RUFY3 NGF NGF SYT4 SYT4 WNT3A WNT3A EIF4G1 EIF4G1 HPN HPN SYT17 SYT17 NRP1 NRP1 ENSMNEP00000030000 ENSMNEP00000030000 ENSMNEP00000030578 ENSMNEP00000030578 EXTL3 EXTL3 SFRP2 SFRP2 NRG1 NRG1 ZFYVE27 ZFYVE27 SDCBP SDCBP LOC105479529 LOC105479529 CRK CRK SLC44A4 SLC44A4 SMAD7 SMAD7 AKAP6 AKAP6 LOC105499585 LOC105499585 DERL2 DERL2 TAF9B TAF9B BCL11A BCL11A TWF2 TWF2 ENSMNEP00000034429 ENSMNEP00000034429 CYBA CYBA F2 F2 ADAM10 ADAM10 ARMC12 ARMC12 LIMK1 LIMK1 SRF SRF MAP3K13 MAP3K13 MLST8 MLST8 CXCL16 CXCL16 ENSMNEP00000037916 ENSMNEP00000037916 S100A8 S100A8 SLC25A33 SLC25A33 ADNP ADNP L1CAM L1CAM NCBP1 NCBP1 ENSMNEP00000039946 ENSMNEP00000039946 MUL1 MUL1 RPS6KA1 RPS6KA1 MAPT MAPT TGFB2 TGFB2 PSMD10 PSMD10 USP47 USP47 DBNL DBNL MAP2K5 MAP2K5 ACSL4 ACSL4 SEMA5A SEMA5A UNC13A UNC13A ZNF639 ZNF639 WNT3 WNT3 SYT3 SYT3 FGFR1OP FGFR1OP SYT2 SYT2 MTPN MTPN CRABP2 CRABP2 ERBB2 ERBB2 DSCAM DSCAM
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
CDKL5Cyclin dependent kinase like 5. (1028 aa)
ADNP2ADNP homeobox 2. (1136 aa)
IGF1Insulin like growth factor 1. (208 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
COMMD5COMM domain containing 5. (224 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
TRIM32Tripartite motif containing 32. (596 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (697 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
SUPV3L1Suv3 like RNA helicase. (787 aa)
SPHK1Sphingosine kinase 1. (470 aa)
NOL12Uncharacterized protein. (213 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (916 aa)
CIB1Calcium and integrin binding 1. (231 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
SHTN1Shootin 1. (636 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
DNPH12'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (237 aa)
IL9Interleukin 9. (145 aa)
PLAAPhospholipase A2 activating protein. (795 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
RASAL1RAS protein activator like 1. (806 aa)
LOC105469173Histone H3; Belongs to the histone H3 family. (136 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (440 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (530 aa)
GOLGA4Golgin A4. (2284 aa)
NTN1Netrin 1. (604 aa)
EDN1Endothelin 1. (211 aa)
ENSMNEP00000008392ECR1_N domain-containing protein. (304 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2. (718 aa)
MEGF8Multiple EGF like domains 8. (2846 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EXOSC9Exosome component 9. (456 aa)
LOC105476302Histone H3.3. (136 aa)
SLC23A2Solute carrier family 23 member 2. (650 aa)
DDX49DEAD-box helicase 49; Belongs to the DEAD box helicase family. (483 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (246 aa)
FN1Fibronectin 1. (2477 aa)
DBN1Drebrin 1. (695 aa)
RNF157Ring finger protein 157. (679 aa)
MAP1BMicrotubule associated protein 1B. (2584 aa)
KLHL22Kelch like family member 22. (634 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1367 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (641 aa)
SYT1Synaptotagmin 1. (422 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ENSMNEP00000013458PDZ domain-containing protein. (259 aa)
KDM2BLysine demethylase 2B. (1307 aa)
ADAM17ADAM metallopeptidase domain 17. (803 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (214 aa)
RND2Rho family GTPase 2. (227 aa)
BRAT1BRCA1 associated ATM activator 1. (821 aa)
ENSMNEP00000015048Histone domain-containing protein. (126 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
EXOSC2Uncharacterized protein. (306 aa)
YAP1Yes associated protein 1. (506 aa)
CDKN2AIPCDKN2A interacting protein. (580 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1691 aa)
CPNE9Copine family member 9. (553 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
CPNE5Copine 5. (593 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
EXOSC4Exosome component 4. (260 aa)
PRR5Proline rich 5. (405 aa)
DISC1DISC1 scaffold protein. (858 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
IGFBP1Insulin like growth factor binding protein 1. (281 aa)
FXNFrataxin. (210 aa)
HDGFL2HDGF like 2. (650 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
MACF1Microtubule actin crosslinking factor 1. (7594 aa)
ENSMNEP00000023008ANK_REP_REGION domain-containing protein. (159 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
POU4F2POU domain protein. (408 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
LOC105497839Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
HYAL1Hyaluronidase. (435 aa)
ITSN2Intersectin 2. (1697 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
RUFY3RUN and FYVE domain containing 3. (594 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
SYT4Synaptotagmin 4. (425 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1604 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
SYT17Synaptotagmin 17. (505 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (925 aa)
ENSMNEP00000030000Uncharacterized protein. (126 aa)
ENSMNEP00000030578PDZ domain-containing protein. (262 aa)
EXTL3Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (919 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
NRG1Neuregulin 1. (645 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (483 aa)
SDCBPSyndecan binding protein. (318 aa)
LOC105479529Microtubule-associated protein. (333 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (708 aa)
SMAD7Mothers against decapentaplegic homolog. (488 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
LOC105499585COMM domain-containing protein. (248 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (265 aa)
TAF9BTATA-box binding protein associated factor 9b. (251 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (838 aa)
TWF2Twinfilin actin binding protein 2. (348 aa)
ENSMNEP00000034429Uncharacterized protein. (291 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (610 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
ARMC12Armadillo repeat containing 12. (367 aa)
LIMK1LIM domain kinase 1. (677 aa)
SRFSerum response factor. (508 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13. (939 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
CXCL16C-X-C motif chemokine ligand 16. (276 aa)
ENSMNEP00000037916C2H2-type domain-containing protein. (457 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
ENSMNEP00000039946MTS domain-containing protein. (197 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAPTMicrotubule-associated protein. (776 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
DBNLDrebrin like. (440 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (472 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
SEMA5ASemaphorin 5A. (1074 aa)
UNC13AUnc-13 homolog A. (1717 aa)
ZNF639Uncharacterized protein. (485 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
SYT3Synaptotagmin 3. (590 aa)
FGFR1OPFGFR1 oncogene partner. (399 aa)
SYT2Synaptotagmin 2. (419 aa)
MTPNMyotrophin. (118 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
DSCAMDS cell adhesion molecule. (1919 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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