31 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPL26	KOW domain-containing protein. (146 aa)
	FBXO31	F-box protein 31. (543 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	TRIAP1	TP53 regulated inhibitor of apoptosis 1. (76 aa)
	CHEK2	Checkpoint kinase 2. (588 aa)
	PML	Promyelocytic leukemia. (882 aa)
	DGKZ	Diacylglycerol kinase. (1172 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	PRAP1	Uncharacterized protein. (153 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	GML	Glycosylphosphatidylinositol anchored molecule like. (158 aa)
	PLK3	Serine/threonine-protein kinase PLK. (608 aa)
	SDE2	SDE2 telomere maintenance homolog. (451 aa)
	ENSMNEP00000027688	KOW domain-containing protein. (145 aa)
	ENSMNEP00000026876	KOW domain-containing protein. (138 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (533 aa)
	RBM38	RNA binding motif protein 38. (237 aa)
	RPS27L	40S ribosomal protein S27. (84 aa)
	WAC	WW domain containing adaptor with coiled-coil. (647 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	ENSMNEP00000013845	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (436 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
	RPL26L1	Ribosomal protein L26 like 1. (145 aa)
	PIDD1	P53-induced death domain protein 1. (936 aa)
	MUC1	Mucin 1, cell surface associated. (449 aa)
	RFWD3	Ring finger and WD repeat domain 3. (774 aa)
	GIGYF2	GRB10 interacting GYF protein 2. (1328 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3032 aa)
	LOC105466147	Uncharacterized protein. (145 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CDK2	ENSMNEP00000001150	ENSMNEP00000043212	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.789
ATM	CHEK2	ENSMNEP00000001150	ENSMNEP00000040143	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 2.	0.989
ATM	PIDD1	ENSMNEP00000001150	ENSMNEP00000009244	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.774
ATM	PRKDC	ENSMNEP00000001150	ENSMNEP00000035447	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.812
CASP2	CRADD	ENSMNEP00000039602	ENSMNEP00000013255	Caspase 2; Belongs to the peptidase C14A family.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.945
CASP2	PIDD1	ENSMNEP00000039602	ENSMNEP00000009244	Caspase 2; Belongs to the peptidase C14A family.	P53-induced death domain protein 1.	0.943
CCND1	CDK2	ENSMNEP00000035178	ENSMNEP00000043212	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.996
CCND1	CDKN1A	ENSMNEP00000035178	ENSMNEP00000002098	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1A.	0.997
CCND1	CDKN1B	ENSMNEP00000035178	ENSMNEP00000015121	Cyclin D1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1B.	0.996
CCND1	FBXO31	ENSMNEP00000035178	ENSMNEP00000043319	Cyclin D1; Belongs to the cyclin family.	F-box protein 31.	0.882
CDK2	ATM	ENSMNEP00000043212	ENSMNEP00000001150	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.789
CDK2	CCND1	ENSMNEP00000043212	ENSMNEP00000035178	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.996
CDK2	CDKN1A	ENSMNEP00000043212	ENSMNEP00000002098	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.999
CDK2	CDKN1B	ENSMNEP00000043212	ENSMNEP00000015121	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1B.	0.999
CDK2	CHEK2	ENSMNEP00000043212	ENSMNEP00000040143	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Checkpoint kinase 2.	0.551
CDK2	PLK3	ENSMNEP00000043212	ENSMNEP00000032102	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.724
CDKN1A	CCND1	ENSMNEP00000002098	ENSMNEP00000035178	Cyclin dependent kinase inhibitor 1A.	Cyclin D1; Belongs to the cyclin family.	0.997
CDKN1A	CDK2	ENSMNEP00000002098	ENSMNEP00000043212	Cyclin dependent kinase inhibitor 1A.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.999
CDKN1A	CDKN1B	ENSMNEP00000002098	ENSMNEP00000015121	Cyclin dependent kinase inhibitor 1A.	Cyclin dependent kinase inhibitor 1B.	0.948
CDKN1B	CCND1	ENSMNEP00000015121	ENSMNEP00000035178	Cyclin dependent kinase inhibitor 1B.	Cyclin D1; Belongs to the cyclin family.	0.996