STRINGSTRING
TLR4 TLR4 LY86 LY86 MAPK14 MAPK14 IL18 IL18 TGFB1 TGFB1 RIPK2 RIPK2 LYN LYN BPI BPI BCL10 BCL10 MALT1 MALT1 IL1B IL1B NFKBIA NFKBIA MYD88 MYD88 TICAM1 TICAM1 TNF TNF IRF3 IRF3 SCARB1 SCARB1 CD180 CD180 AKT1 AKT1 LBP LBP CD14 CD14 MAPK3 MAPK3 PRKCE PRKCE MTDH MTDH LOC105485104 LOC105485104 ENSMNEP00000019682 ENSMNEP00000019682 IRAK1 IRAK1 PTAFR PTAFR NOS3 NOS3 LY96 LY96 MAPK1 MAPK1 PTPN22 PTPN22 LOC105468574 LOC105468574 CD6 CD6 PLCG2 PLCG2 IRAK2 IRAK2 BPIFC BPIFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
LY86Lymphocyte antigen 86. (162 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
LYNTyrosine-protein kinase. (512 aa)
BPIBactericidal permeability increasing protein. (511 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
MALT1MALT1 paracaspase. (824 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IRF3Interferon regulatory factor 3. (422 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (553 aa)
CD180CD180 molecule. (661 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LBPLipopolysaccharide binding protein. (481 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
MTDHMetadherin. (535 aa)
LOC105485104C-C motif chemokine. (92 aa)
ENSMNEP00000019682Uncharacterized protein. (203 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (717 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
LY96MD-2. (160 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
LOC105468574C-C motif chemokine. (92 aa)
CD6CD6 molecule. (699 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (625 aa)
BPIFCBPI fold containing family C. (507 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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