STRINGSTRING
DDIT3 DDIT3 IL2 IL2 AXL AXL IL20RB IL20RB ARID5A ARID5A LGALS7B LGALS7B ENSMNEP00000002245 ENSMNEP00000002245 PGLYRP1 PGLYRP1 TLR8 TLR8 SIRPA SIRPA WNT5A WNT5A PDCD1LG2 PDCD1LG2 IL12RB1 IL12RB1 FZD5 FZD5 CRTAM CRTAM CEBPG CEBPG ABL1 ABL1 ZNF683 ZNF683 TRIM27 TRIM27 IRF8 IRF8 KLRK1 KLRK1 FADD FADD TNF TNF TYK2 TYK2 CD2 CD2 HRAS HRAS CD96 CD96 IL36RN IL36RN LTA LTA TXK TXK IL1B IL1B ZC3H12A ZC3H12A CLEC7A CLEC7A TLR4 TLR4 HLA-DPA1 HLA-DPA1 ISL1 ISL1 HAVCR2 HAVCR2 IL23R IL23R PYCARD PYCARD IL10 IL10 IL27 IL27 ZFPM1 ZFPM1 INHBA INHBA HMHB1 HMHB1 PGLYRP2 PGLYRP2 IL33 IL33 RIPK2 RIPK2 PDE4B PDE4B PGLYRP3 PGLYRP3 IL18R1 IL18R1 INHA INHA IL18 IL18 SLAMF6 SLAMF6 CD160 CD160 SLC11A1 SLC11A1 CD244 CD244 SLC7A5 SLC7A5 BTN3A1 BTN3A1 C1QBP C1QBP IL12A IL12A GATA3 GATA3 IL27RA IL27RA ISG15 ISG15 LOC105474889 LOC105474889 PDE4D PDE4D NR1H4 NR1H4 SCRIB SCRIB IL1R1 IL1R1 NLRP6 NLRP6 RARA RARA HLA-DPB1 HLA-DPB1 LRRC1 LRRC1 LOC105476929 LOC105476929 PTPN22 PTPN22 VSIR VSIR CCR7 CCR7 SCGB1A1 SCGB1A1 IL21 IL21 JAK2 JAK2 TLR3 TLR3 RIPK3 RIPK3 IFNL1 IFNL1 CD14 CD14 FAM49B FAM49B NOD2 NOD2 IL12RB2 IL12RB2 CD226 CD226 RASGRP1 RASGRP1 ENSMNEP00000018637 ENSMNEP00000018637 CD3E CD3E ENSMNEP00000021981 ENSMNEP00000021981 BCL3 BCL3 LOC105476888 LOC105476888 TNFSF4 TNFSF4 FOXP3 FOXP3 IL23A IL23A SLAMF1 SLAMF1 GAS6 GAS6 CD276 CD276 ENSMNEP00000027080 ENSMNEP00000027080 TLR7 TLR7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
LGALS7BGalectin. (136 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
SIRPAUncharacterized protein. (507 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (678 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
ZNF683Zinc finger protein 683. (524 aa)
TRIM27Tripartite motif containing 27. (513 aa)
IRF8Interferon regulatory factor 8. (434 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
CD2CD2 molecule. (351 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CD96CD96 molecule. (552 aa)
IL36RNInterleukin-1. (155 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
TXKTyrosine-protein kinase. (527 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
IL23RInterleukin 23 receptor. (576 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL27Interleukin 27. (243 aa)
ZFPM1Zinc finger protein, FOG family member 1. (976 aa)
INHBAInhibin subunit beta A. (426 aa)
HMHB1Histocompatibility minor HB-1. (41 aa)
PGLYRP2Peptidoglycan recognition protein 2. (634 aa)
IL33Interleukin 33. (270 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
PDE4BPhosphodiesterase. (736 aa)
PGLYRP3Peptidoglycan recognition protein 3. (341 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
INHAInhibin subunit alpha. (384 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SLAMF6SLAM family member 6. (331 aa)
CD160CD160 molecule. (181 aa)
SLC11A1Solute carrier family 11 member 1. (477 aa)
CD244CD244 molecule. (367 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
BTN3A1Butyrophilin subfamily 3 member A1. (510 aa)
C1QBPComplement C1q binding protein. (281 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GATA3GATA binding protein 3. (444 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
LOC105474889AIG1-type G domain-containing protein. (307 aa)
PDE4DPhosphodiesterase. (809 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
SCRIBScribble planar cell polarity protein. (1698 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
NLRP6NLR family pyrin domain containing 6. (1044 aa)
RARARetinoic acid receptor alpha. (477 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
LOC105476929Galectin. (212 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SCGB1A1Secretoglobin family 1A member 1. (91 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
IFNL1Interferon lambda 1. (202 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
FAM49BFamily with sequence similarity 49 member B. (365 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (842 aa)
CD226CD226 molecule. (316 aa)
RASGRP1RAS guanyl releasing protein 1. (832 aa)
ENSMNEP00000018637Uncharacterized protein. (309 aa)
CD3ECD3e molecule. (198 aa)
ENSMNEP00000021981Uncharacterized protein. (161 aa)
BCL3BCL3 transcription coactivator. (454 aa)
LOC105476888Galectin. (355 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
FOXP3Forkhead box P3. (456 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
GAS6Growth arrest specific 6. (683 aa)
CD276CD276 molecule. (534 aa)
ENSMNEP00000027080Galectin. (136 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
Server load: low (34%) [HD]