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DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) | ||||
IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) | ||||
AXL | AXL receptor tyrosine kinase. (894 aa) | ||||
IL20RB | Interleukin 20 receptor subunit beta. (311 aa) | ||||
ARID5A | AT-rich interaction domain 5A. (594 aa) | ||||
LGALS7B | Galectin. (136 aa) | ||||
ENSMNEP00000002245 | Ig-like domain-containing protein. (232 aa) | ||||
PGLYRP1 | Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (196 aa) | ||||
TLR8 | Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa) | ||||
SIRPA | Uncharacterized protein. (507 aa) | ||||
WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa) | ||||
PDCD1LG2 | Programmed cell death 1 ligand 2. (273 aa) | ||||
IL12RB1 | Interleukin 12 receptor subunit beta 1. (678 aa) | ||||
FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) | ||||
CRTAM | Cytotoxic and regulatory T cell molecule. (393 aa) | ||||
CEBPG | CCAAT enhancer binding protein gamma. (150 aa) | ||||
ABL1 | Tyrosine-protein kinase. (1148 aa) | ||||
ZNF683 | Zinc finger protein 683. (524 aa) | ||||
TRIM27 | Tripartite motif containing 27. (513 aa) | ||||
IRF8 | Interferon regulatory factor 8. (434 aa) | ||||
KLRK1 | Killer cell lectin like receptor K1. (216 aa) | ||||
FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) | ||||
TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) | ||||
TYK2 | Tyrosine-protein kinase. (1190 aa) | ||||
CD2 | CD2 molecule. (351 aa) | ||||
HRAS | HRas proto-oncogene, GTPase. (189 aa) | ||||
CD96 | CD96 molecule. (552 aa) | ||||
IL36RN | Interleukin-1. (155 aa) | ||||
LTA | Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa) | ||||
TXK | Tyrosine-protein kinase. (527 aa) | ||||
IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa) | ||||
ZC3H12A | Zinc finger CCCH-type containing 12A. (601 aa) | ||||
CLEC7A | C-type lectin domain containing 7A. (247 aa) | ||||
TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa) | ||||
HLA-DPA1 | Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa) | ||||
ISL1 | ISL LIM homeobox 1. (349 aa) | ||||
HAVCR2 | Hepatitis A virus cellular receptor 2. (294 aa) | ||||
IL23R | Interleukin 23 receptor. (576 aa) | ||||
PYCARD | PYD and CARD domain containing. (195 aa) | ||||
IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) | ||||
IL27 | Interleukin 27. (243 aa) | ||||
ZFPM1 | Zinc finger protein, FOG family member 1. (976 aa) | ||||
INHBA | Inhibin subunit beta A. (426 aa) | ||||
HMHB1 | Histocompatibility minor HB-1. (41 aa) | ||||
PGLYRP2 | Peptidoglycan recognition protein 2. (634 aa) | ||||
IL33 | Interleukin 33. (270 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) | ||||
PDE4B | Phosphodiesterase. (736 aa) | ||||
PGLYRP3 | Peptidoglycan recognition protein 3. (341 aa) | ||||
IL18R1 | Interleukin 18 receptor 1. (540 aa) | ||||
INHA | Inhibin subunit alpha. (384 aa) | ||||
IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) | ||||
SLAMF6 | SLAM family member 6. (331 aa) | ||||
CD160 | CD160 molecule. (181 aa) | ||||
SLC11A1 | Solute carrier family 11 member 1. (477 aa) | ||||
CD244 | CD244 molecule. (367 aa) | ||||
SLC7A5 | Solute carrier family 7 member 5. (507 aa) | ||||
BTN3A1 | Butyrophilin subfamily 3 member A1. (510 aa) | ||||
C1QBP | Complement C1q binding protein. (281 aa) | ||||
IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) | ||||
GATA3 | GATA binding protein 3. (444 aa) | ||||
IL27RA | Interleukin 27 receptor subunit alpha. (636 aa) | ||||
ISG15 | ISG15 ubiquitin like modifier. (165 aa) | ||||
LOC105474889 | AIG1-type G domain-containing protein. (307 aa) | ||||
PDE4D | Phosphodiesterase. (809 aa) | ||||
NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) | ||||
SCRIB | Scribble planar cell polarity protein. (1698 aa) | ||||
IL1R1 | Interleukin 1 receptor type 1. (569 aa) | ||||
NLRP6 | NLR family pyrin domain containing 6. (1044 aa) | ||||
RARA | Retinoic acid receptor alpha. (477 aa) | ||||
HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (268 aa) | ||||
LRRC1 | Leucine rich repeat containing 1. (524 aa) | ||||
LOC105476929 | Galectin. (212 aa) | ||||
PTPN22 | Protein tyrosine phosphatase non-receptor type 22. (813 aa) | ||||
VSIR | V-set immunoregulatory receptor. (311 aa) | ||||
CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa) | ||||
SCGB1A1 | Secretoglobin family 1A member 1. (91 aa) | ||||
IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (162 aa) | ||||
JAK2 | Tyrosine-protein kinase. (1139 aa) | ||||
TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) | ||||
RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) | ||||
IFNL1 | Interferon lambda 1. (202 aa) | ||||
CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) | ||||
FAM49B | Family with sequence similarity 49 member B. (365 aa) | ||||
NOD2 | Nucleotide binding oligomerization domain containing 2. (1044 aa) | ||||
IL12RB2 | Interleukin 12 receptor subunit beta 2. (842 aa) | ||||
CD226 | CD226 molecule. (316 aa) | ||||
RASGRP1 | RAS guanyl releasing protein 1. (832 aa) | ||||
ENSMNEP00000018637 | Uncharacterized protein. (309 aa) | ||||
CD3E | CD3e molecule. (198 aa) | ||||
ENSMNEP00000021981 | Uncharacterized protein. (161 aa) | ||||
BCL3 | BCL3 transcription coactivator. (454 aa) | ||||
LOC105476888 | Galectin. (355 aa) | ||||
TNFSF4 | TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa) | ||||
FOXP3 | Forkhead box P3. (456 aa) | ||||
IL23A | Interleukin 23 subunit alpha. (189 aa) | ||||
SLAMF1 | Signaling lymphocytic activation molecule family member 1. (356 aa) | ||||
GAS6 | Growth arrest specific 6. (683 aa) | ||||
CD276 | CD276 molecule. (534 aa) | ||||
ENSMNEP00000027080 | Galectin. (136 aa) | ||||
TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |