STRINGSTRING
LOC105480535 LOC105480535 APP APP TLR1 TLR1 ARID5A ARID5A CEBPB CEBPB MBP MBP SOCS5 SOCS5 PLCG2 PLCG2 TLR8 TLR8 SIRPA SIRPA PTPN11 PTPN11 WNT5A WNT5A NLRP10 NLRP10 ENSMNEP00000007269 ENSMNEP00000007269 INPP5D INPP5D RAB7B RAB7B CD36 CD36 HMGB1 HMGB1 NR1H4 NR1H4 POU2F2 POU2F2 LILRA5 LILRA5 ENSMNEP00000010344 ENSMNEP00000010344 AQP4 AQP4 ARHGEF2 ARHGEF2 ENSMNEP00000012002 ENSMNEP00000012002 PTPN22 PTPN22 NCKAP1L NCKAP1L ENSMNEP00000012679 ENSMNEP00000012679 CARD9 CARD9 NOS2 NOS2 CUNHXorf40B CUNHXorf40B IL1RL2 IL1RL2 TLR3 TLR3 MMP8 MMP8 GHSR GHSR ADORA2B ADORA2B C1QTNF3 C1QTNF3 KLF2 KLF2 NOD2 NOD2 TSLP TSLP SETD4 SETD4 IFIH1 IFIH1 IRAK3 IRAK3 AGER AGER CX3CL1 CX3CL1 SCIMP SCIMP STAT3 STAT3 INAVA INAVA IL17D IL17D LPL LPL TMEM130 TMEM130 SPON2 SPON2 XBP1 XBP1 LBP LBP TIRAP TIRAP LEP LEP CSK CSK NLRP12 NLRP12 TNFSF4 TNFSF4 HYAL2 HYAL2 FOXP3 FOXP3 TNFAIP3 TNFAIP3 SLAMF1 SLAMF1 IL17RA IL17RA TREM2 TREM2 CD74 CD74 AIF1 AIF1 NOD1 NOD1 GAS6 GAS6 IL1RAP IL1RAP TLR7 TLR7 BTK BTK ENSMNEP00000027695 ENSMNEP00000027695 IL16 IL16 SYK SYK TNF TNF TICAM1 TICAM1 ZBTB20 ZBTB20 PTPN6 PTPN6 SELENOS SELENOS TMEM106A TMEM106A IL17F IL17F MYD88 MYD88 SYT11 SYT11 IL36RN IL36RN IL36A IL36A ORM1 ORM1 CD84 CD84 EREG EREG F2R F2R IL1B IL1B SPHK2 SPHK2 AKIRIN2 AKIRIN2 HGF HGF ZC3H12A ZC3H12A NLRX1 NLRX1 CYBA CYBA CLEC7A CLEC7A MAPK13 MAPK13 TLR4 TLR4 NMBR NMBR IL17A IL17A NMB NMB BCL10 BCL10 BPI BPI DHX9 DHX9 ISL1 ISL1 HAVCR2 HAVCR2 PYCARD PYCARD IL10 IL10 DDX58 DDX58 IL33 IL33 RIPK2 RIPK2 TRAF6 TRAF6 IL17RC IL17RC POU2AF1 POU2AF1 BSG BSG IL37 IL37 RABGEF1 RABGEF1 GHRL GHRL IL6 IL6 FOXJ1 FOXJ1 MAPKAPK2 MAPKAPK2 TRPV4 TRPV4 AFAP1L2 AFAP1L2 IL6R IL6R IL27RA IL27RA BANK1 BANK1 IFNG IFNG NLRC3 NLRC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105480535TIR domain-containing protein. (1033 aa)
APPAmyloid beta precursor protein. (770 aa)
TLR1Toll-like receptor. (786 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
MBPMyelin basic protein. (330 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
SIRPAUncharacterized protein. (507 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
NLRP10NLR family pyrin domain containing 10. (663 aa)
ENSMNEP00000007269VPS9 domain-containing protein. (363 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1203 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
HMGB1High mobility group box 1. (215 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
POU2F2POU domain protein. (622 aa)
LILRA5Leukocyte immunoglobulin like receptor A5. (299 aa)
ENSMNEP00000010344Uncharacterized protein. (206 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
ENSMNEP00000012679Uncharacterized protein. (262 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
CUNHXorf40BASCH domain-containing protein. (158 aa)
IL1RL2Interleukin 1 receptor like 2. (562 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
MMP8Matrix metallopeptidase 8. (467 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
KLF2Kruppel like factor 2. (355 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
SETD4SET domain containing 4. (440 aa)
IFIH1Interferon induced with helicase C domain 1. (1025 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
AGERAdvanced glycosylation end-product specific receptor. (414 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (126 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
INAVAInnate immunity activator. (703 aa)
IL17DInterleukin 17D. (202 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
TMEM130Transmembrane protein 130. (413 aa)
SPON2Spondin 2. (331 aa)
XBP1BZIP domain-containing protein. (380 aa)
LBPLipopolysaccharide binding protein. (481 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CSKTyrosine-protein kinase. (450 aa)
NLRP12NLR family pyrin domain containing 12. (973 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
HYAL2Hyaluronidase. (473 aa)
FOXP3Forkhead box P3. (456 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
IL17RAInterleukin 17 receptor A. (865 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
CD74CD74 molecule. (294 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
GAS6Growth arrest specific 6. (683 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
BTKTyrosine-protein kinase. (659 aa)
ENSMNEP00000027695Uncharacterized protein. (445 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1378 aa)
SYKTyrosine-protein kinase. (629 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
SELENOSSelenoprotein S. (190 aa)
TMEM106ATransmembrane protein 106A. (262 aa)
IL17FInterleukin 17F. (163 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
SYT11Synaptotagmin 11. (431 aa)
IL36RNInterleukin-1. (155 aa)
IL36AInterleukin-1. (179 aa)
ORM1Orosomucoid 1. (219 aa)
CD84CD84 molecule. (345 aa)
EREGEpiregulin. (169 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
SPHK2Sphingosine kinase 2. (653 aa)
AKIRIN2Akirin 2. (205 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
NLRX1NLR family member X1. (972 aa)
CYBACytochrome b-245 alpha chain. (197 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
IL17AInterleukin 17A. (155 aa)
NMBNeuromedin B. (153 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
BPIBactericidal permeability increasing protein. (511 aa)
DHX9DExH-box helicase 9. (1275 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
DDX58DExD/H-box helicase 58. (925 aa)
IL33Interleukin 33. (270 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
IL17RCInterleukin 17 receptor C. (787 aa)
POU2AF1POU class 2 homeobox associating factor 1. (257 aa)
BSGBasigin (Ok blood group). (366 aa)
IL37Interleukin-1. (235 aa)
RABGEF1A20-type domain-containing protein. (469 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
IL6Interleukin 6. (214 aa)
FOXJ1Forkhead box J1. (421 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
AFAP1L2Actin filament associated protein 1 like 2. (848 aa)
IL6RInterleukin 6 receptor. (467 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (786 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
NLRC3NLR family CARD domain containing 3. (1174 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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