STRINGSTRING
TIRAP TIRAP APP APP IFNG IFNG OAS3 OAS3 IL6R IL6R OAS1 OAS1 EGR1 EGR1 TRPV4 TRPV4 HIF1A HIF1A ALOX15B ALOX15B ADIPOQ ADIPOQ IL18 IL18 RIPK2 RIPK2 IL33 IL33 PYCARD PYCARD HAVCR2 HAVCR2 CSF1R CSF1R IL17A IL17A MIF MIF TLR4 TLR4 CLEC7A CLEC7A EIF2AK2 EIF2AK2 IL1B IL1B CD84 CD84 MYD88 MYD88 IL17F IL17F IL7 IL7 TICAM1 TICAM1 TNF TNF SYK SYK TLR7 TLR7 AIF1 AIF1 CD74 CD74 IL17RA IL17RA TNFSF4 TNFSF4 LBP LBP DEFB124 DEFB124 ADCYAP1 ADCYAP1 LPL LPL AZU1 AZU1 ENSMNEP00000018637 ENSMNEP00000018637 AGER AGER CHIA CHIA TSLP TSLP NOD2 NOD2 IL4R IL4R ADORA2B ADORA2B DDX3X DDX3X MCOLN2 MCOLN2 TLR3 TLR3 ADAM17 ADAM17 CARD9 CARD9 ENSMNEP00000010344 ENSMNEP00000010344 HMGB1 HMGB1 FFAR2 FFAR2 WNT5A WNT5A AIRE AIRE TRIM32 TRIM32 C5 C5 MBP MBP IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIRAPTIR domain containing adaptor protein. (234 aa)
APPAmyloid beta precursor protein. (770 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1076 aa)
IL6RInterleukin 6 receptor. (467 aa)
OAS12'-5'-oligoadenylate synthetase 1. (488 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IL33Interleukin 33. (270 aa)
PYCARDPYD and CARD domain containing. (195 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
IL17AInterleukin 17A. (155 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (488 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
CD84CD84 molecule. (345 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
IL17FInterleukin 17F. (163 aa)
IL7Interleukin 7. (184 aa)
TICAM1Toll like receptor adaptor molecule 1. (519 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SYKTyrosine-protein kinase. (629 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CD74CD74 molecule. (294 aa)
IL17RAInterleukin 17 receptor A. (865 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
LBPLipopolysaccharide binding protein. (481 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (73 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
AZU1Azurocidin 1. (250 aa)
ENSMNEP00000018637Uncharacterized protein. (309 aa)
AGERAdvanced glycosylation end-product specific receptor. (414 aa)
CHIAChitinase acidic; Belongs to the glycosyl hydrolase 18 family. (470 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
IL4RInterleukin 4 receptor. (825 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (331 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
MCOLN2Mucolipin 2. (566 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
ADAM17ADAM metallopeptidase domain 17. (803 aa)
CARD9Caspase recruitment domain family member 9. (535 aa)
ENSMNEP00000010344Uncharacterized protein. (206 aa)
HMGB1High mobility group box 1. (215 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
AIREAutoimmune regulator. (542 aa)
TRIM32Tripartite motif containing 32. (596 aa)
C5Complement C5. (1676 aa)
MBPMyelin basic protein. (330 aa)
IL6Interleukin 6. (214 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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