STRINGSTRING
IL2 IL2 ARID5A ARID5A ENSMNEP00000002245 ENSMNEP00000002245 TLR8 TLR8 WNT5A WNT5A IL12RB1 IL12RB1 FZD5 FZD5 CRTAM CRTAM CEBPG CEBPG ABL1 ABL1 TRIM27 TRIM27 IRF8 IRF8 HMHB1 HMHB1 PDE4D PDE4D SCRIB SCRIB IL1R1 IL1R1 HLA-DPB1 HLA-DPB1 LRRC1 LRRC1 PTPN22 PTPN22 IL21 IL21 JAK2 JAK2 TLR3 TLR3 IFNL1 IFNL1 CD14 CD14 IL12RB2 IL12RB2 CD226 CD226 RASGRP1 RASGRP1 CD3E CD3E BCL3 BCL3 TNFSF4 TNFSF4 IL23A IL23A SLAMF1 SLAMF1 CD276 CD276 TLR7 TLR7 FAM49B FAM49B KLRK1 KLRK1 FADD FADD TNF TNF TYK2 TYK2 CD2 CD2 HRAS HRAS LTA LTA TXK TXK IL1B IL1B CLEC7A CLEC7A TLR4 TLR4 HLA-DPA1 HLA-DPA1 ISL1 ISL1 HAVCR2 HAVCR2 IL23R IL23R PYCARD PYCARD IL27 IL27 ZFPM1 ZFPM1 RIPK2 RIPK2 PDE4B PDE4B IL18R1 IL18R1 IL18 IL18 SLAMF6 SLAMF6 CD160 CD160 SLC11A1 SLC11A1 CD244 CD244 SLC7A5 SLC7A5 BTN3A1 BTN3A1 IL12A IL12A IL27RA IL27RA ISG15 ISG15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
ARID5AAT-rich interaction domain 5A. (594 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (678 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CRTAMCytotoxic and regulatory T cell molecule. (393 aa)
CEBPGCCAAT enhancer binding protein gamma. (150 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
TRIM27Tripartite motif containing 27. (513 aa)
IRF8Interferon regulatory factor 8. (434 aa)
HMHB1Histocompatibility minor HB-1. (41 aa)
PDE4DPhosphodiesterase. (809 aa)
SCRIBScribble planar cell polarity protein. (1698 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
IFNL1Interferon lambda 1. (202 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (842 aa)
CD226CD226 molecule. (316 aa)
RASGRP1RAS guanyl releasing protein 1. (832 aa)
CD3ECD3e molecule. (198 aa)
BCL3BCL3 transcription coactivator. (454 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
CD276CD276 molecule. (534 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
FAM49BFamily with sequence similarity 49 member B. (365 aa)
KLRK1Killer cell lectin like receptor K1. (216 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
CD2CD2 molecule. (351 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
TXKTyrosine-protein kinase. (527 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
IL23RInterleukin 23 receptor. (576 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL27Interleukin 27. (243 aa)
ZFPM1Zinc finger protein, FOG family member 1. (976 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
PDE4BPhosphodiesterase. (736 aa)
IL18R1Interleukin 18 receptor 1. (540 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SLAMF6SLAM family member 6. (331 aa)
CD160CD160 molecule. (181 aa)
SLC11A1Solute carrier family 11 member 1. (477 aa)
CD244CD244 molecule. (367 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
BTN3A1Butyrophilin subfamily 3 member A1. (510 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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