55 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP1	Caspase 1; Belongs to the peptidase C14A family. (442 aa)
	IL6	Interleukin 6. (214 aa)
	CCL19	C-C motif chemokine. (123 aa)
	NLRP12	NLR family pyrin domain containing 12. (973 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (953 aa)
	MEFV	MEFV innate immuity regulator, pyrin. (786 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TMEM106A	Transmembrane protein 106A. (262 aa)
	IFI16	Interferon gamma inducible protein 16. (729 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	ORM1	Orosomucoid 1. (219 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (487 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	MALT1	MALT1 paracaspase. (824 aa)
	IL17A	Interleukin 17A. (155 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	NLRP3	NLR family pyrin domain containing 3. (1035 aa)
	TRIM16	Uncharacterized protein. (557 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (545 aa)
	ENSMNEP00000044641	Uncharacterized protein. (111 aa)
	LOC105493689	Uncharacterized protein; Belongs to the peptidase C14A family. (410 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	INAVA	Innate immunity activator. (703 aa)
	AZU1	Azurocidin 1. (250 aa)
	NLRP1	NLR family pyrin domain containing 1. (1456 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (373 aa)
	PYDC1	Pyrin domain containing 1. (88 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
	LOC105485104	C-C motif chemokine. (92 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (426 aa)
	STMP1	Short transmembrane mitochondrial protein 1. (47 aa)
	STAT3	Signal transducer and activator of transcription. (660 aa)
	AGER	Advanced glycosylation end-product specific receptor. (414 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1044 aa)
	NLRP2	NLR family pyrin domain containing 2. (1039 aa)
	GSDMD	Gasdermin D. (523 aa)
	JAK2	Tyrosine-protein kinase. (1139 aa)
	LOC105468574	C-C motif chemokine. (92 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	NAIP	NLR family apoptosis inhibitory protein. (1356 aa)
	PYHIN1	Pyrin and HIN domain family member 1. (494 aa)
	ENSMNEP00000010344	Uncharacterized protein. (206 aa)
	LILRA5	Leukocyte immunoglobulin like receptor A5. (299 aa)
	HMGB1	High mobility group box 1. (215 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	ENSMNEP00000007520	CARD domain-containing protein. (359 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSMNEP00000018479	ENSMNEP00000045820	Advanced glycosylation end-product specific receptor.	Amyloid beta precursor protein.	0.650
AGER	ENSMNEP00000010344	ENSMNEP00000018479	ENSMNEP00000010344	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.575
AGER	HMGB1	ENSMNEP00000018479	ENSMNEP00000008829	Advanced glycosylation end-product specific receptor.	High mobility group box 1.	0.575
AGER	JAK2	ENSMNEP00000018479	ENSMNEP00000014154	Advanced glycosylation end-product specific receptor.	Tyrosine-protein kinase.	0.918
AIM2	CASP1	ENSMNEP00000012916	ENSMNEP00000001601	Absent in melanoma 2.	Caspase 1; Belongs to the peptidase C14A family.	0.671
AIM2	ENSMNEP00000007520	ENSMNEP00000012916	ENSMNEP00000007520	Absent in melanoma 2.	CARD domain-containing protein.	0.619
AIM2	GSDMD	ENSMNEP00000012916	ENSMNEP00000014364	Absent in melanoma 2.	Gasdermin D.	0.665
AIM2	IFI16	ENSMNEP00000012916	ENSMNEP00000030357	Absent in melanoma 2.	Interferon gamma inducible protein 16.	0.914
AIM2	LOC105493689	ENSMNEP00000012916	ENSMNEP00000045751	Absent in melanoma 2.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.631
AIM2	MEFV	ENSMNEP00000012916	ENSMNEP00000028284	Absent in melanoma 2.	MEFV innate immuity regulator, pyrin.	0.757
AIM2	NAIP	ENSMNEP00000012916	ENSMNEP00000012364	Absent in melanoma 2.	NLR family apoptosis inhibitory protein.	0.485
AIM2	NLRP1	ENSMNEP00000012916	ENSMNEP00000020184	Absent in melanoma 2.	NLR family pyrin domain containing 1.	0.839
AIM2	NLRP12	ENSMNEP00000012916	ENSMNEP00000023610	Absent in melanoma 2.	NLR family pyrin domain containing 12.	0.457
AIM2	NLRP2	ENSMNEP00000012916	ENSMNEP00000015393	Absent in melanoma 2.	NLR family pyrin domain containing 2.	0.418
AIM2	PYCARD	ENSMNEP00000012916	ENSMNEP00000036486	Absent in melanoma 2.	PYD and CARD domain containing.	0.983
AIM2	PYHIN1	ENSMNEP00000012916	ENSMNEP00000012083	Absent in melanoma 2.	Pyrin and HIN domain family member 1.	0.467
AIM2	TLR8	ENSMNEP00000012916	ENSMNEP00000003246	Absent in melanoma 2.	Toll like receptor 8; Belongs to the Toll-like receptor family.	0.448
APP	AGER	ENSMNEP00000045820	ENSMNEP00000018479	Amyloid beta precursor protein.	Advanced glycosylation end-product specific receptor.	0.650
APP	CD36	ENSMNEP00000045820	ENSMNEP00000008350	Amyloid beta precursor protein.	CD36 molecule; Belongs to the CD36 family.	0.490
APP	IL6	ENSMNEP00000045820	ENSMNEP00000000727	Amyloid beta precursor protein.	Interleukin 6.	0.403