STRINGSTRING
AFAP1L2 AFAP1L2 DDIT3 DDIT3 APOA2 APOA2 ENSMNEP00000000212 ENSMNEP00000000212 IL6 IL6 ZNF580 ZNF580 LAMTOR5 LAMTOR5 TLR8 TLR8 WNT5A WNT5A FFAR2 FFAR2 ELANE ELANE NLRP10 NLRP10 SERPINE1 SERPINE1 ENSMNEP00000007677 ENSMNEP00000007677 ENSMNEP00000008139 ENSMNEP00000008139 PRG3 PRG3 ENSMNEP00000010524 ENSMNEP00000010524 RIPK1 RIPK1 CD58 CD58 PARK7 PARK7 ENSMNEP00000013103 ENSMNEP00000013103 NOS2 NOS2 TLR3 TLR3 CD14 CD14 NOD2 NOD2 F3 F3 STAT3 STAT3 IL17D IL17D ENSMNEP00000020734 ENSMNEP00000020734 LBP LBP TIRAP TIRAP PLA2G1B PLA2G1B LEP LEP HYAL2 HYAL2 CD74 CD74 NOD1 NOD1 TLR7 TLR7 RELA RELA SYK SYK FADD FADD TNF TNF PRKD2 PRKD2 CD2 CD2 GDF2 GDF2 MYD88 MYD88 ENSMNEP00000032418 ENSMNEP00000032418 F2R F2R IL1B IL1B ENSMNEP00000034131 ENSMNEP00000034131 CLEC7A CLEC7A TLR4 TLR4 BCL10 BCL10 PYCARD PYCARD CHI3L1 CHI3L1 CALCA CALCA DDX58 DDX58 ENSMNEP00000038197 ENSMNEP00000038197 IL18 IL18 ADIPOQ ADIPOQ CD244 CD244
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFAP1L2Actin filament associated protein 1 like 2. (848 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
APOA2Apolipoprotein A2. (132 aa)
ENSMNEP00000000212Uncharacterized protein. (175 aa)
IL6Interleukin 6. (214 aa)
ZNF580Zinc finger protein 580. (172 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (169 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1059 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (419 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (263 aa)
NLRP10NLR family pyrin domain containing 10. (663 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (379 aa)
ENSMNEP00000007677Uncharacterized protein. (200 aa)
ENSMNEP00000008139Uncharacterized protein. (111 aa)
PRG3Proteoglycan 3, pro eosinophil major basic protein 2. (225 aa)
ENSMNEP00000010524DJ-1_PfpI domain-containing protein. (186 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (693 aa)
CD58CD58 molecule. (250 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
ENSMNEP00000013103Uncharacterized protein. (90 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1063 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
F3Coagulation factor III, tissue factor. (296 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
IL17DInterleukin 17D. (202 aa)
ENSMNEP00000020734Uncharacterized protein. (74 aa)
LBPLipopolysaccharide binding protein. (481 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
PLA2G1BPhospholipase A(2). (148 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
HYAL2Hyaluronidase. (473 aa)
CD74CD74 molecule. (294 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
SYKTyrosine-protein kinase. (629 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
CD2CD2 molecule. (351 aa)
GDF2Growth differentiation factor 2. (429 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
ENSMNEP00000032418DJ-1_PfpI domain-containing protein. (166 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
ENSMNEP00000034131DJ-1_PfpI domain-containing protein. (170 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PYCARDPYD and CARD domain containing. (195 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (405 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
DDX58DExD/H-box helicase 58. (925 aa)
ENSMNEP00000038197Uncharacterized protein. (121 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (274 aa)
CD244CD244 molecule. (367 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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