STRINGSTRING
EIF5A2 EIF5A2 CSDE1 CSDE1 USP16 USP16 ERBB2 ERBB2 LARP6 LARP6 PCIF1 PCIF1 RPS6KB1 RPS6KB1 ENSMNEP00000045775 ENSMNEP00000045775 YBX3 YBX3 IMPACT IMPACT CPEB3 CPEB3 EIF3E EIF3E CDK5RAP1 CDK5RAP1 IFNG IFNG ENSMNEP00000045066 ENSMNEP00000045066 NIBAN1 NIBAN1 ITGA2 ITGA2 CCN1 CCN1 ENSMNEP00000043163 ENSMNEP00000043163 NGRN NGRN YBX1 YBX1 ROCK2 ROCK2 RPL5 RPL5 JMJD4 JMJD4 LOC105472095 LOC105472095 C1QBP C1QBP HNRNPU HNRNPU ENSMNEP00000041867 ENSMNEP00000041867 RBM4B RBM4B FASTKD2 FASTKD2 CLU CLU PRR16 PRR16 TENT5B TENT5B IFNGR1 IFNGR1 THBS1 THBS1 LRRTM3 LRRTM3 PLXNB2 PLXNB2 RBM3 RBM3 SYNCRIP SYNCRIP ENSMNEP00000037489 ENSMNEP00000037489 ENSMNEP00000037428 ENSMNEP00000037428 POLR2G POLR2G ENSMNEP00000036868 ENSMNEP00000036868 SP1 SP1 NAT10 NAT10 DHX9 DHX9 YTHDF2 YTHDF2 ENPP7 ENPP7 ENSMNEP00000035495 ENSMNEP00000035495 PRKDC PRKDC METTL3 METTL3 RPUSD3 RPUSD3 SPHK2 SPHK2 BARHL2 BARHL2 UPF3B UPF3B DHX36 DHX36 RMND1 RMND1 CTIF CTIF EIF4A3 EIF4A3 LARP1 LARP1 PRKCD PRKCD NPM1 NPM1 NCK2 NCK2 GSK3A GSK3A RPL26 RPL26 DAZL DAZL ENSMNEP00000029986 ENSMNEP00000029986 MRPS27 MRPS27 TNF TNF METTL5 METTL5 ENSMNEP00000028677 ENSMNEP00000028677 EIF4G1 EIF4G1 VIM VIM RELA RELA ENSMNEP00000027688 ENSMNEP00000027688 PKM PKM ENSMNEP00000027628 ENSMNEP00000027628 POLDIP3 POLDIP3 ENSMNEP00000026876 ENSMNEP00000026876 SIRT3 SIRT3 CYP1B1 CYP1B1 ABCA2 ABCA2 ENSMNEP00000026588 ENSMNEP00000026588 TARBP2 TARBP2 UPF3A UPF3A TENT4B TENT4B EFNA1 EFNA1 PLA2G6 PLA2G6 SLC2A13 SLC2A13 NCK1 NCK1 EIF2B5 EIF2B5 LIN28A LIN28A ABCF1 ABCF1 ENSMNEP00000024458 ENSMNEP00000024458 PPP1R15A PPP1R15A ENSMNEP00000024169 ENSMNEP00000024169 KHDRBS1 KHDRBS1 POLR2D POLR2D ENSMNEP00000023592 ENSMNEP00000023592 BCL3 BCL3 ENSMNEP00000022200 ENSMNEP00000022200 ENSMNEP00000021981 ENSMNEP00000021981 MPV17L2 MPV17L2 PYM1 PYM1 LARP4 LARP4 ENSMNEP00000020831 ENSMNEP00000020831 EIF5A EIF5A IGF2BP1 IGF2BP1 CD28 CD28 EPHA4 EPHA4 RPS27L RPS27L CIRBP CIRBP PTK2B PTK2B BOLL BOLL NSUN5 NSUN5 METTL14 METTL14 PINK1 PINK1 NOD2 NOD2 RCC1L RCC1L RPS6KB2 RPS6KB2 ENSMNEP00000016207 ENSMNEP00000016207 SAMD4A SAMD4A PAIP1 PAIP1 DDX3X DDX3X FXR1 FXR1 ENSMNEP00000015085 ENSMNEP00000015085 HABP4 HABP4 YTHDF3 YTHDF3 FXR2 FXR2 GSAP GSAP ABCG1 ABCG1 YTHDF1 YTHDF1 EIF6 EIF6 ENSMNEP00000012292 ENSMNEP00000012292 ENSMNEP00000012230 ENSMNEP00000012230 LARP1B LARP1B ENSMNEP00000004019 ENSMNEP00000004019 ENSMNEP00000003725 ENSMNEP00000003725 PASK PASK DNAJC3 DNAJC3 PICALM PICALM ENSMNEP00000011228 ENSMNEP00000011228 RPL26L1 RPL26L1 MTOR MTOR PIWIL2 PIWIL2 TENT4A TENT4A CNBP CNBP ELAVL1 ELAVL1 METTL8 METTL8 LOC105464452 LOC105464452 NFE2L2 NFE2L2 HNRNPD HNRNPD ENSMNEP00000006648 ENSMNEP00000006648 RPUSD4 RPUSD4 DHX29 DHX29 ZCCHC4 ZCCHC4 LOC105492342 LOC105492342 FMR1 FMR1 EIF2AK4 EIF2AK4 MIF4GD MIF4GD ENSMNEP00000004781 ENSMNEP00000004781 ENSMNEP00000004611 ENSMNEP00000004611 SOX4 SOX4 ENSMNEP00000004093 ENSMNEP00000004093 FASTKD3 FASTKD3 ENSMNEP00000003442 ENSMNEP00000003442 PLD1 PLD1 LARP4B LARP4B EIF3D EIF3D TRUB2 TRUB2 ENSMNEP00000002293 ENSMNEP00000002293 PABPC1 PABPC1 GUF1 GUF1 ENSMNEP00000001787 ENSMNEP00000001787 UHMK1 UHMK1 LOC105466147 LOC105466147 IL6 IL6 ENSMNEP00000000249 ENSMNEP00000000249
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF5A2Eukaryotic translation initiation factor 5A. (153 aa)
CSDE1Cold shock domain containing E1. (844 aa)
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (839 aa)
ERBB2Receptor protein-tyrosine kinase. (1390 aa)
LARP6La ribonucleoprotein domain family member 6. (491 aa)
PCIF1PDX1 C-terminal inhibiting factor 1. (704 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSMNEP00000045775Pyruvate kinase; Belongs to the pyruvate kinase family. (523 aa)
YBX3Y-box binding protein 3. (372 aa)
IMPACTRWD domain-containing protein. (320 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (721 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (496 aa)
CDK5RAP1CDK5 regulatory subunit associated protein 1. (587 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
ENSMNEP00000045066Ribosomal_L18_c domain-containing protein. (280 aa)
NIBAN1Niban apoptosis regulator 1. (928 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
CCN1Cellular communication network factor 1. (381 aa)
ENSMNEP00000043163Uncharacterized protein. (121 aa)
NGRNNeugrin, neurite outgrowth associated. (291 aa)
YBX1Y-box binding protein 1. (324 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1474 aa)
RPL5Ribosomal_L18_c domain-containing protein. (276 aa)
JMJD4Jumonji domain containing 4. (463 aa)
LOC105472095Coiled-coil_56 domain-containing protein. (106 aa)
C1QBPComplement C1q binding protein. (281 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
ENSMNEP00000041867Uncharacterized protein; Belongs to the peptidase C14A family. (265 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
FASTKD2FAST kinase domains 2. (694 aa)
CLUClusterin. (534 aa)
PRR16Proline rich 16. (304 aa)
TENT5BTerminal nucleotidyltransferase 5B. (425 aa)
IFNGR1Interferon gamma receptor 1. (488 aa)
THBS1Thrombospondin 1. (1173 aa)
LRRTM3Leucine rich repeat transmembrane neuronal 3. (581 aa)
PLXNB2Plexin B2. (1898 aa)
RBM3RNA binding motif protein 3. (157 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
ENSMNEP00000037489Uncharacterized protein. (254 aa)
ENSMNEP00000037428CSD_1 domain-containing protein. (288 aa)
POLR2GRNA polymerase II subunit G. (234 aa)
ENSMNEP00000036868Coiled-coil_56 domain-containing protein. (91 aa)
SP1Sp1 transcription factor. (786 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
DHX9DExH-box helicase 9. (1275 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (579 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (489 aa)
ENSMNEP00000035495Smg4_UPF3 domain-containing protein. (194 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4054 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
RPUSD3RNA pseudouridine synthase D3. (351 aa)
SPHK2Sphingosine kinase 2. (653 aa)
BARHL2BarH like homeobox 2. (385 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (483 aa)
DHX36DEAH-box helicase 36. (1008 aa)
RMND1Required for meiotic nuclear division 1 homolog. (449 aa)
CTIFCap binding complex dependent translation initiation factor. (614 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (428 aa)
LARP1La ribonucleoprotein domain family member 1. (978 aa)
PRKCDProtein kinase C. (729 aa)
NPM1Nucleophosmin 1. (294 aa)
NCK2Cytoplasmic protein. (382 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
RPL26KOW domain-containing protein. (146 aa)
DAZLDeleted in azoospermia like. (315 aa)
ENSMNEP00000029986Uncharacterized protein; Belongs to the DEAD box helicase family. (387 aa)
MRPS27Mitochondrial ribosomal protein S27. (428 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
METTL5Methyltransferase like 5. (209 aa)
ENSMNEP00000028677HTH La-type RNA-binding domain-containing protein. (552 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1604 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
ENSMNEP00000027688KOW domain-containing protein. (145 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
ENSMNEP00000027628MTS domain-containing protein. (178 aa)
POLDIP3DNA polymerase delta interacting protein 3. (436 aa)
ENSMNEP00000026876KOW domain-containing protein. (138 aa)
SIRT3Sirtuin 3. (365 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
ABCA2ATP binding cassette subfamily A member 2. (2406 aa)
ENSMNEP00000026588Uncharacterized protein. (179 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (472 aa)
TENT4BTerminal nucleotidyltransferase 4B. (701 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
PLA2G6Phospholipase A2 group VI. (836 aa)
SLC2A13Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (647 aa)
NCK1Cytoplasmic protein. (377 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (716 aa)
LIN28ALin-28 homolog A. (209 aa)
ABCF1ATP binding cassette subfamily F member 1. (950 aa)
ENSMNEP00000024458eIF3_N domain-containing protein; Belongs to the eIF-3 subunit E family. (159 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (674 aa)
ENSMNEP00000024169Nucleoplasmin domain-containing protein. (220 aa)
KHDRBS1KH RNA binding domain containing, signal transduction associated 1. (443 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
ENSMNEP00000023592RWD domain-containing protein. (306 aa)
BCL3BCL3 transcription coactivator. (454 aa)
ENSMNEP00000022200Uncharacterized protein. (232 aa)
ENSMNEP00000021981Uncharacterized protein. (161 aa)
MPV17L2MPV17 mitochondrial inner membrane protein like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (206 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (204 aa)
LARP4La ribonucleoprotein domain family member 4. (703 aa)
ENSMNEP00000020831CSP domain-containing protein. (318 aa)
EIF5AeIF-5a domain-containing protein. (184 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (583 aa)
CD28CD28 molecule. (220 aa)
EPHA4EPH receptor A4. (997 aa)
RPS27L40S ribosomal protein S27. (84 aa)
CIRBPCold inducible RNA binding protein. (284 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
BOLLBoule homolog, RNA binding protein. (311 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (472 aa)
PINK1PTEN induced kinase 1. (581 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1044 aa)
RCC1LRCC1 like. (453 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMNEP00000016207Uncharacterized protein. (253 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
PAIP1Poly(A) binding protein interacting protein 1. (477 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
ENSMNEP00000015085Pyruvate kinase; Belongs to the pyruvate kinase family. (463 aa)
HABP4Hyaluronan binding protein 4. (405 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (585 aa)
FXR2FMR1 autosomal homolog 2. (673 aa)
GSAPGamma-secretase activating protein. (799 aa)
ABCG1ATP binding cassette subfamily G member 1. (690 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (559 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
ENSMNEP00000012292Uncharacterized protein. (208 aa)
ENSMNEP00000012230Uncharacterized protein. (216 aa)
LARP1BLa ribonucleoprotein domain family member 1B. (831 aa)
ENSMNEP00000004019Uncharacterized protein; Belongs to the peptidase C14A family. (242 aa)
ENSMNEP00000003725Nucleoplasmin domain-containing protein. (218 aa)
PASKPAS domain containing serine/threonine kinase. (1321 aa)
DNAJC3DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (686 aa)
ENSMNEP00000011228CSD_1 domain-containing protein. (305 aa)
RPL26L1Ribosomal protein L26 like 1. (145 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (960 aa)
TENT4ATerminal nucleotidyltransferase 4A. (788 aa)
CNBPUncharacterized protein. (177 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
METTL8Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (374 aa)
LOC105464452Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (618 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (355 aa)
ENSMNEP00000006648HTH La-type RNA-binding domain-containing protein. (247 aa)
RPUSD4RNA pseudouridine synthase D4. (377 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1367 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (513 aa)
LOC105492342Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
FMR1Fragile X mental retardation 1. (632 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1649 aa)
MIF4GDMIF4G domain containing. (262 aa)
ENSMNEP00000004781Eukaryotic translation initiation factor 5A. (107 aa)
ENSMNEP00000004611Ribosomal_L18_c domain-containing protein. (268 aa)
SOX4Transcription factor SOX. (475 aa)
ENSMNEP00000004093Uncharacterized protein. (305 aa)
FASTKD3FAST kinase domains 3. (657 aa)
ENSMNEP00000003442Uncharacterized protein. (81 aa)
PLD1Phospholipase. (1074 aa)
LARP4BLa ribonucleoprotein domain family member 4B. (786 aa)
EIF3DEukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required [...] (548 aa)
TRUB2TruB pseudouridine synthase family member 2. (333 aa)
ENSMNEP00000002293Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (578 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (578 aa)
GUF1Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (663 aa)
ENSMNEP00000001787Uncharacterized protein. (530 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
LOC105466147Uncharacterized protein. (145 aa)
IL6Interleukin 6. (214 aa)
ENSMNEP00000000249RRM domain-containing protein. (157 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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