STRINGSTRING
VPS72 VPS72 SALL4 SALL4 LDB2 LDB2 NODAL NODAL SFRP1 SFRP1 WNT7A WNT7A MED28 MED28 NOG NOG LIF LIF MED21 MED21 LDB1 LDB1 REST REST MED15 MED15 WNT9B WNT9B ZFP36L2 ZFP36L2 NR2E1 NR2E1 FGF10 FGF10 MED27 MED27 STAT3 STAT3 KIT KIT BMPR1A BMPR1A KLF10 KLF10 ENSMNEP00000016378 ENSMNEP00000016378 YAP1 YAP1 KLF4 KLF4 ENSMNEP00000015044 ENSMNEP00000015044 RIF1 RIF1 MED14 MED14 LOC105473189 LOC105473189 MED30 MED30 SMC1A SMC1A GATA2 GATA2 BCL9 BCL9 SIX2 SIX2 BRAF BRAF BCL9L BCL9L LIG4 LIG4 ZHX2 ZHX2 NIPBL NIPBL SOX4 SOX4 MED7 MED7 ASCL2 ASCL2 MED12 MED12 FGF4 FGF4 SOX9 SOX9 CDX2 CDX2 CUL4A CUL4A LRP5 LRP5 SKI SKI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
SALL4Spalt like transcription factor 4. (951 aa)
LDB2LIM domain binding 2. (360 aa)
NODALNodal growth differentiation factor. (347 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MED28Mediator complex subunit 28. (178 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
LDB1LIM domain binding 1. (411 aa)
RESTRE1 silencing transcription factor. (1106 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (788 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
ZFP36L2ZFP36 ring finger protein like 2. (493 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MED27Mediator complex subunit 27. (311 aa)
STAT3Signal transducer and activator of transcription. (660 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
KLF10Kruppel like factor 10. (480 aa)
ENSMNEP00000016378Protein kinase domain-containing protein. (652 aa)
YAP1Yes associated protein 1. (506 aa)
KLF4Kruppel like factor 4. (479 aa)
ENSMNEP00000015044Uncharacterized protein. (267 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1454 aa)
LOC105473189Uncharacterized protein. (477 aa)
MED30Mediator complex subunit 30. (178 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
GATA2GATA binding protein 2. (480 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
SIX2SIX homeobox 2. (292 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
BCL9LBCL9 like. (1498 aa)
LIG4DNA ligase. (911 aa)
ZHX2Zinc fingers and homeoboxes 2. (837 aa)
NIPBLNipped-B protein. (2804 aa)
SOX4Transcription factor SOX. (475 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
MED12Mediator complex subunit 12. (2178 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CDX2Caudal type homeobox 2. (313 aa)
CUL4ACullin 4A; Belongs to the cullin family. (745 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1599 aa)
SKISKI proto-oncogene. (728 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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