STRINGSTRING
AP2B1 AP2B1 HECTD1 HECTD1 EDNRA EDNRA NPRL3 NPRL3 TBX1 TBX1 LRP2 LRP2 EYA1 EYA1 PDE2A PDE2A SOX4 SOX4 ROBO1 ROBO1 PKD2 PKD2 ADAMTS6 ADAMTS6 NKX3-1 NKX3-1 ENSMNEP00000010927 ENSMNEP00000010927 FOXH1 FOXH1 COL3A1 COL3A1 PROX1 PROX1 PRDM1 PRDM1 LRP1 LRP1 BMPR1A BMPR1A PDGFRB PDGFRB FKBP10 FKBP10 HEY1 HEY1 SUFU SUFU SMAD6 SMAD6 LEP LEP ENG ENG ROBO2 ROBO2 NDST1 NDST1 CNTRL CNTRL PLXND1 PLXND1 HEY2 HEY2 TBX2 TBX2 JAG1 JAG1 MYLK MYLK ACVRL1 ACVRL1 DLL4 DLL4 SEC24B SEC24B DCTN5 DCTN5 CHD7 CHD7 SRF SRF PRICKLE1 PRICKLE1 ADAMTS9 ADAMTS9 EGR2 EGR2 LOX LOX EFEMP2 EFEMP2 TGFB2 TGFB2 LOXL1 LOXL1 NGFR NGFR TFAP2B TFAP2B FGF8 FGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AP2B1AP complex subunit beta. (959 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (505 aa)
TBX1T-box transcription factor 1. (426 aa)
LRP2LDL receptor related protein 2. (4655 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
PDE2APhosphodiesterase. (942 aa)
SOX4Transcription factor SOX. (475 aa)
ROBO1Roundabout guidance receptor 1. (1539 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (969 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1117 aa)
NKX3-1NK3 homeobox 1. (232 aa)
ENSMNEP00000010927B2-adapt-app_C domain-containing protein. (224 aa)
FOXH1Forkhead box H1. (366 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
PROX1Prospero homeobox 1. (737 aa)
PRDM1PR/SET domain 1. (825 aa)
LRP1LDL receptor related protein 1. (4544 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FKBP10Peptidylprolyl isomerase. (582 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENGEndoglin. (658 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
CNTRLCentriolin. (2329 aa)
PLXND1Plexin D1. (1925 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TBX2T-box transcription factor 2. (588 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
MYLKMyosin light chain kinase. (1934 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1261 aa)
DCTN5Dynactin subunit 5. (182 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
SRFSerum response factor. (508 aa)
PRICKLE1Prickle planar cell polarity protein 1. (848 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
EGR2Early growth response 2. (426 aa)
LOXLysyl oxidase. (417 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOXL1Lysyl oxidase like 1. (576 aa)
NGFRNerve growth factor receptor. (439 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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