STRINGSTRING
NCKAP1L NCKAP1L PTPN22 PTPN22 ENSMNEP00000012002 ENSMNEP00000012002 HLA-DPB1 HLA-DPB1 ICOSLG ICOSLG ZP4 ZP4 PNP PNP CD80 CD80 CD55 CD55 ANXA1 ANXA1 TNFSF9 TNFSF9 CD70 CD70 RPS3 RPS3 TNFSF13B TNFSF13B CD86 CD86 JAK2 JAK2 PRKCQ PRKCQ IL12RB1 IL12RB1 PDCD1LG2 PDCD1LG2 ENSMNEP00000002245 ENSMNEP00000002245 IGF1 IGF1 CCL19 CCL19 CD1D CD1D IL27RA IL27RA SLC7A1 SLC7A1 DHPS DHPS CD274 CD274 VTCN1 VTCN1 RASAL3 RASAL3 ENSMNEP00000040701 ENSMNEP00000040701 TNFRSF13C TNFRSF13C IL18 IL18 SHH SHH TRAF6 TRAF6 RIPK2 RIPK2 KITLG KITLG SPTA1 SPTA1 TMIGD2 TMIGD2 PYCARD PYCARD IL23R IL23R HAVCR2 HAVCR2 GPAM GPAM TGFBR2 TGFBR2 HLA-DPA1 HLA-DPA1 JAK3 JAK3 IGFBP2 IGFBP2 IL15 IL15 ENSMNEP00000033549 ENSMNEP00000033549 IL1B IL1B TFRC TFRC CD40LG CD40LG NCK2 NCK2 TYK2 TYK2 FADD FADD SYK SYK ZAP70 ZAP70 CD276 CD276 PPP3CA PPP3CA AIF1 AIF1 IGF2 IGF2 SLAMF1 SLAMF1 ENSMNEP00000025089 ENSMNEP00000025089 IL23A IL23A NCK1 NCK1 FOXP3 FOXP3 CD81 CD81 IL6 IL6 CARD11 CARD11 IL2 IL2 TNFSF4 TNFSF4 CORO1A CORO1A IL6ST IL6ST VCAM1 VCAM1 EFNB1 EFNB1 LEP LEP HHLA2 HHLA2 CD6 CD6 IL21 IL21 ENSMNEP00000013168 ENSMNEP00000013168 PTPRC PTPRC ENSMNEP00000012406 ENSMNEP00000012406 STAT5B STAT5B ENSMNEP00000021409 ENSMNEP00000021409 CD24 CD24 CD28 CD28 DNAJA3 DNAJA3 CCDC88B CCDC88B CD3E CD3E CD209 CD209 AGER AGER IL12RB2 IL12RB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCKAP1LNCK associated protein 1 like. (1134 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (813 aa)
ENSMNEP00000012002TNF receptor-associated factor. (457 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (268 aa)
ICOSLGUncharacterized protein. (302 aa)
ZP4Zona pellucida glycoprotein 4. (538 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
CD80CD80 molecule. (288 aa)
CD55CD55 molecule (Cromer blood group). (551 aa)
ANXA1Annexin. (346 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (251 aa)
CD70TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (316 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (284 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (285 aa)
CD86CD86 molecule. (329 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (678 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (273 aa)
ENSMNEP00000002245Ig-like domain-containing protein. (232 aa)
IGF1Insulin like growth factor 1. (208 aa)
CCL19C-C motif chemokine. (123 aa)
CD1DCD1d molecule. (337 aa)
IL27RAInterleukin 27 receptor subunit alpha. (636 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
DHPSUncharacterized protein. (369 aa)
CD274CD274 molecule. (318 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (285 aa)
RASAL3RAS protein activator like 3. (1011 aa)
ENSMNEP00000040701Uncharacterized protein. (164 aa)
TNFRSF13CTNF receptor superfamily member 13C. (172 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (462 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)
TMIGD2Transmembrane and immunoglobulin domain containing 2. (170 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL23RInterleukin 23 receptor. (576 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (294 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
JAK3Tyrosine-protein kinase. (1088 aa)
IGFBP2Insulin like growth factor binding protein 2. (326 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
ENSMNEP00000033549Uncharacterized protein. (168 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
TFRCTransferrin receptor. (764 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
NCK2Cytoplasmic protein. (382 aa)
TYK2Tyrosine-protein kinase. (1190 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
SYKTyrosine-protein kinase. (629 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CD276CD276 molecule. (534 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
IGF2Insulin like growth factor 2. (236 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (356 aa)
ENSMNEP00000025089Ig-like domain-containing protein. (235 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
NCK1Cytoplasmic protein. (377 aa)
FOXP3Forkhead box P3. (456 aa)
CD81Tetraspanin. (274 aa)
IL6Interleukin 6. (214 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
HHLA2HERV-H LTR-associating 2. (426 aa)
CD6CD6 molecule. (699 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
ENSMNEP00000013168Ribosomal_S3_C domain-containing protein. (225 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
ENSMNEP00000012406Uncharacterized protein. (72 aa)
STAT5BSignal transducer and activator of transcription. (783 aa)
ENSMNEP00000021409Uncharacterized protein. (123 aa)
CD24Uncharacterized protein. (127 aa)
CD28CD28 molecule. (220 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
CCDC88BCoiled-coil domain containing 88B. (1476 aa)
CD3ECD3e molecule. (198 aa)
CD209CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens (By similarity). (413 aa)
AGERAdvanced glycosylation end-product specific receptor. (414 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (842 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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