STRINGSTRING
IL20 IL20 IL6 IL6 IGF1 IGF1 LOC105483006 LOC105483006 CD40 CD40 IL2 IL2 HDAC2 HDAC2 HSF1 HSF1 IFNG IFNG PIBF1 PIBF1 IL6R IL6R IL12A IL12A GH1 GH1 HES5 HES5 LOC105483028 LOC105483028 ENSMNEP00000041110 ENSMNEP00000041110 OSBP OSBP FGFR3 FGFR3 IL18 IL18 IL3 IL3 OSM OSM LYN LYN ERBB4 ERBB4 IL23R IL23R ISL1 ISL1 HCLS1 HCLS1 CSF1R CSF1R EPO EPO IL15 IL15 HPX HPX LIF LIF ARL2BP ARL2BP LOC105468986 LOC105468986 LOC105469367 LOC105469367 CSF2 CSF2 IL31RA IL31RA CTF1 CTF1 IL23A IL23A PARP14 PARP14 ENSMNEP00000024454 ENSMNEP00000024454 IL6ST IL6ST CLCF1 CLCF1 TNFRSF18 TNFRSF18 PARP9 PARP9 KIT KIT CRLF1 CRLF1 TNFSF18 TNFSF18 TSLP TSLP FLT3 FLT3 IFNL1 IFNL1 JAK2 JAK2 LOC105483030 LOC105483030 IL21 IL21 TNFRSF1A TNFRSF1A FYN FYN PTK6 PTK6 IL24 IL24
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL20Interleukin 20. (176 aa)
IL6Interleukin 6. (214 aa)
IGF1Insulin like growth factor 1. (208 aa)
LOC105483006Uncharacterized protein. (197 aa)
CD40CD40 molecule. (278 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
HSF1Heat shock transcription factor 1. (529 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (763 aa)
IL6RInterleukin 6 receptor. (467 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GH1Uncharacterized protein. (217 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
LOC105483028Uncharacterized protein. (217 aa)
ENSMNEP00000041110Uncharacterized protein. (177 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (805 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (151 aa)
OSMOncostatin M. (252 aa)
LYNTyrosine-protein kinase. (512 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IL23RInterleukin 23 receptor. (576 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (475 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ARL2BPADP ribosylation factor like GTPase 2 binding protein. (163 aa)
LOC105468986Uncharacterized protein. (227 aa)
LOC105469367Uncharacterized protein. (147 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL31RAInterleukin 31 receptor A. (763 aa)
CTF1Cardiotrophin 1. (201 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PARP14Poly [ADP-ribose] polymerase. (1800 aa)
ENSMNEP00000024454ARL2_Bind_BART domain-containing protein. (169 aa)
IL6STInterleukin 6 signal transducer. (942 aa)
CLCF1Cardiotrophin like cytokine factor 1. (230 aa)
TNFRSF18TNF receptor superfamily member 18. (241 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (818 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
TNFSF18TNF superfamily member 18. (199 aa)
TSLPThymic stromal lymphopoietin. (159 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (995 aa)
IFNL1Interferon lambda 1. (202 aa)
JAK2Tyrosine-protein kinase. (1139 aa)
LOC105483030Uncharacterized protein. (199 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FYNTyrosine-protein kinase. (537 aa)
PTK6Tyrosine-protein kinase. (397 aa)
IL24Interleukin 24. (207 aa)
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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