35 items (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASS1	Argininosuccinate synthase 1. (412 aa)
	INSR	Tyrosine-protein kinase receptor. (1306 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	TRPV1	Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (748 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	CD36	CD36 molecule; Belongs to the CD36 family. (472 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (969 aa)
	ENSMNEP00000010946	Uncharacterized protein. (423 aa)
	ENSMNEP00000011447	Uncharacterized protein. (427 aa)
	ITGB2	Integrin beta. (921 aa)
	MMP8	Matrix metallopeptidase 8. (467 aa)
	KLF4	Kruppel like factor 4. (479 aa)
	PTX3	Pentraxin 3. (392 aa)
	KLF2	Kruppel like factor 2. (355 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (513 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	NOS1AP	PID domain-containing protein. (695 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	KLRK1	Killer cell lectin like receptor K1. (216 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (519 aa)
	DDAH2	Dimethylarginine dimethylaminohydrolase 2. (285 aa)
	ENSMNEP00000030542	Uncharacterized protein. (361 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (268 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (826 aa)
	ASL	Argininosuccinate lyase. (464 aa)
	CLU	Clusterin. (534 aa)
	ENSMNEP00000040888	Uncharacterized protein. (375 aa)
	DDAH1	Dimethylarginine dimethylaminohydrolase 1. (285 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (165 aa)

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGTR2	PTGS2	ENSMNEP00000006573	ENSMNEP00000019419	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Prostaglandin-endoperoxide synthase 2.	0.553
AGXT2	ASL	ENSMNEP00000018080	ENSMNEP00000035818	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Argininosuccinate lyase.	0.440
AGXT2	DDAH1	ENSMNEP00000018080	ENSMNEP00000042740	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dimethylarginine dimethylaminohydrolase 1.	0.671
AGXT2	DDAH2	ENSMNEP00000018080	ENSMNEP00000029536	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dimethylarginine dimethylaminohydrolase 2.	0.601
AKT1	ESR1	ENSMNEP00000026038	ENSMNEP00000018606	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.506
AKT1	IFNG	ENSMNEP00000026038	ENSMNEP00000045088	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.415
AKT1	IL1B	ENSMNEP00000026038	ENSMNEP00000033521	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.493
AKT1	KLF4	ENSMNEP00000026038	ENSMNEP00000016029	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Kruppel like factor 4.	0.462
AKT1	SMAD3	ENSMNEP00000026038	ENSMNEP00000018363	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.696
AKT1	TLR4	ENSMNEP00000026038	ENSMNEP00000035110	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.428
AKT1	TNF	ENSMNEP00000026038	ENSMNEP00000029202	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.540
ASL	AGXT2	ENSMNEP00000035818	ENSMNEP00000018080	Argininosuccinate lyase.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.440
ASL	ASS1	ENSMNEP00000035818	ENSMNEP00000042557	Argininosuccinate lyase.	Argininosuccinate synthase 1.	0.995
ASL	DDAH1	ENSMNEP00000035818	ENSMNEP00000042740	Argininosuccinate lyase.	Dimethylarginine dimethylaminohydrolase 1.	0.469
ASL	DDAH2	ENSMNEP00000035818	ENSMNEP00000029536	Argininosuccinate lyase.	Dimethylarginine dimethylaminohydrolase 2.	0.466
ASL	ENSMNEP00000010946	ENSMNEP00000035818	ENSMNEP00000010946	Argininosuccinate lyase.	Uncharacterized protein.	0.975
ASL	ENSMNEP00000011447	ENSMNEP00000035818	ENSMNEP00000011447	Argininosuccinate lyase.	Uncharacterized protein.	0.974
ASL	ENSMNEP00000030542	ENSMNEP00000035818	ENSMNEP00000030542	Argininosuccinate lyase.	Uncharacterized protein.	0.992
ASL	ENSMNEP00000040888	ENSMNEP00000035818	ENSMNEP00000040888	Argininosuccinate lyase.	Uncharacterized protein.	0.975
ASS1	ASL	ENSMNEP00000042557	ENSMNEP00000035818	Argininosuccinate synthase 1.	Argininosuccinate lyase.	0.995