node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREB1 | FOS | ENSMNEP00000011914 | ENSMNEP00000015060 | cAMP responsive element binding protein 1. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.630 |
CSF1 | IFNG | ENSMNEP00000028466 | ENSMNEP00000045088 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.590 |
CSF1 | TNF | ENSMNEP00000028466 | ENSMNEP00000029202 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.586 |
CSF1 | TNFSF11 | ENSMNEP00000028466 | ENSMNEP00000015065 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Tumor necrosis factor ligand superfamily member. | 0.513 |
CSF1 | TREM2 | ENSMNEP00000028466 | ENSMNEP00000026141 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Triggering receptor expressed on myeloid cells 2. | 0.467 |
ENSMNEP00000012002 | TNF | ENSMNEP00000012002 | ENSMNEP00000029202 | TNF receptor-associated factor. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.663 |
ENSMNEP00000012002 | TNFSF11 | ENSMNEP00000012002 | ENSMNEP00000015065 | TNF receptor-associated factor. | Tumor necrosis factor ligand superfamily member. | 0.601 |
FOS | CREB1 | ENSMNEP00000015060 | ENSMNEP00000011914 | Fos proto-oncogene, AP-1 transcription factor subunit. | cAMP responsive element binding protein 1. | 0.630 |
FOS | TNFSF11 | ENSMNEP00000015060 | ENSMNEP00000015065 | Fos proto-oncogene, AP-1 transcription factor subunit. | Tumor necrosis factor ligand superfamily member. | 0.468 |
IFNG | CSF1 | ENSMNEP00000045088 | ENSMNEP00000028466 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.590 |
IFNG | IL17A | ENSMNEP00000045088 | ENSMNEP00000035713 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Interleukin 17A. | 0.770 |
IFNG | IL23A | ENSMNEP00000045088 | ENSMNEP00000024978 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Interleukin 23 subunit alpha. | 0.657 |
IFNG | IL23R | ENSMNEP00000045088 | ENSMNEP00000036377 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Interleukin 23 receptor. | 0.870 |
IFNG | TNF | ENSMNEP00000045088 | ENSMNEP00000029202 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.845 |
IFNG | TREM2 | ENSMNEP00000045088 | ENSMNEP00000026141 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Triggering receptor expressed on myeloid cells 2. | 0.484 |
IL17A | IFNG | ENSMNEP00000035713 | ENSMNEP00000045088 | Interleukin 17A. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.770 |
IL17A | IL23A | ENSMNEP00000035713 | ENSMNEP00000024978 | Interleukin 17A. | Interleukin 23 subunit alpha. | 0.516 |
IL17A | IL23R | ENSMNEP00000035713 | ENSMNEP00000036377 | Interleukin 17A. | Interleukin 23 receptor. | 0.586 |
IL17A | TNF | ENSMNEP00000035713 | ENSMNEP00000029202 | Interleukin 17A. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.667 |
IL23A | IFNG | ENSMNEP00000024978 | ENSMNEP00000045088 | Interleukin 23 subunit alpha. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.657 |